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Protein

ER membrane protein complex subunit 2

Gene

EMC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:EMC2
Synonyms:TTC35
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:28463 EMC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002479362 – 297ER membrane protein complex subunit 2Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei255N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5E993
PRIDEiQ5E993

Expressioni

Gene expression databases

BgeeiENSBTAG00000010006

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013197

Structurei

3D structure databases

ProteinModelPortaliQ5E993
SMRiQ5E993
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 120TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati192 – 225TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the EMC2 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060 Eukaryota
ENOG410YT6B LUCA
GeneTreeiENSGT00390000011922
HOGENOMiHOG000007547
HOVERGENiHBG055231
InParanoidiQ5E993
OMAiHLYCEQY
OrthoDBiEOG091G0EOK
TreeFamiTF312997

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL ISEYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPYNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK
260 270 280 290
KDNMKYASWA ASQINKAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,805
Last modified:March 15, 2005 - v1
Checksum:i44D65E13DC688724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021027 mRNA Translation: AAX09044.1
BC102870 mRNA Translation: AAI02871.1
BC142076 mRNA Translation: AAI42077.1
RefSeqiNP_001073796.1, NM_001080327.1
UniGeneiBt.20597

Genome annotation databases

EnsembliENSBTAT00000013197; ENSBTAP00000013197; ENSBTAG00000010006
GeneIDi616813
KEGGibta:616813

Similar proteinsi

Entry informationi

Entry nameiEMC2_BOVIN
AccessioniPrimary (citable) accession number: Q5E993
Secondary accession number(s): A5PJE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health