Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER membrane protein complex subunit 2

Gene

EMC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:EMC2
Synonyms:TTC35
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000247936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei255 – 2551N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5E993.
PRIDEiQ5E993.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013197.

Structurei

3D structure databases

ProteinModelPortaliQ5E993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati192 – 22534TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the EMC2 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060. Eukaryota.
ENOG410YT6B. LUCA.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ5E993.
OMAiGGVWEYL.
OrthoDBiEOG7QK0C9.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL ISEYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPYNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK
260 270 280 290
KDNMKYASWA ASQINKAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,805
Last modified:March 15, 2005 - v1
Checksum:i44D65E13DC688724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021027 mRNA. Translation: AAX09044.1.
BC102870 mRNA. Translation: AAI02871.1.
BC142076 mRNA. Translation: AAI42077.1.
RefSeqiNP_001073796.1. NM_001080327.1.
UniGeneiBt.20597.

Genome annotation databases

EnsembliENSBTAT00000013197; ENSBTAP00000013197; ENSBTAG00000010006.
GeneIDi616813.
KEGGibta:616813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021027 mRNA. Translation: AAX09044.1.
BC102870 mRNA. Translation: AAI02871.1.
BC142076 mRNA. Translation: AAI42077.1.
RefSeqiNP_001073796.1. NM_001080327.1.
UniGeneiBt.20597.

3D structure databases

ProteinModelPortaliQ5E993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013197.

Proteomic databases

PaxDbiQ5E993.
PRIDEiQ5E993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013197; ENSBTAP00000013197; ENSBTAG00000010006.
GeneIDi616813.
KEGGibta:616813.

Organism-specific databases

CTDi9694.

Phylogenomic databases

eggNOGiKOG3060. Eukaryota.
ENOG410YT6B. LUCA.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ5E993.
OMAiGGVWEYL.
OrthoDBiEOG7QK0C9.
TreeFamiTF312997.

Miscellaneous databases

NextBioi20900328.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum and Liver.

Entry informationi

Entry nameiEMC2_BOVIN
AccessioniPrimary (citable) accession number: Q5E993
Secondary accession number(s): A5PJE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.