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Q5E985

- HYAL1_BOVIN

UniProt

Q5E985 - HYAL1_BOVIN

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Protein
Hyaluronidase-1
Gene
HYAL1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Proton donor By similarity

GO - Molecular functioni

  1. hyaluronan synthase activity Source: UniProtKB
  2. hyalurononglucosaminidase activity Source: UniProtKB
  3. transcription factor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cellular response to UV-B Source: UniProtKB
  4. cellular response to interleukin-1 Source: UniProtKB
  5. cellular response to pH Source: UniProtKB
  6. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  7. hyaluronan biosynthetic process Source: UniProtKB
  8. hyaluronan catabolic process Source: UniProtKB
  9. hyaluronan metabolic process Source: UniProtKB
  10. inflammatory response Source: UniProtKB
  11. negative regulation of cell growth Source: UniProtKB
  12. positive regulation of angiogenesis Source: UniProtKB
  13. positive regulation of cell adhesion Source: UniProtKB
  14. positive regulation of cell growth Source: UniProtKB
  15. positive regulation of epithelial cell migration Source: UniProtKB
  16. positive regulation of epithelial cell proliferation Source: UniProtKB
  17. positive regulation of growth Source: UniProtKB
  18. positive regulation of hyaluranon cable assembly Source: UniProtKB
  19. response to antibiotic Source: UniProtKB
  20. response to reactive oxygen species Source: UniProtKB
  21. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_217191. CS/DS degradation.
REACT_224746. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Gene namesi
Name:HYAL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. hyaluranon cable Source: UniProtKB
  5. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 450415Hyaluronidase-1
PRO_0000042623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 348 By similarity
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi222 ↔ 236 By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi373 ↔ 384 By similarity
Disulfide bondi378 ↔ 433 By similarity
Glycosylationi398 – 3981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi435 ↔ 444 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5E985.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000611.

Structurei

3D structure databases

ProteinModelPortaliQ5E985.
SMRiQ5E985. Positions 38-450.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 44412EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ5E985.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E985-1 [UniParc]FASTAAdd to Basket

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MRPFSLEVSL HLPWAMAAHL LPVCTLFLNL LSMTQGSRDP VVPNQPFTTI    50
WNANTEWCMK KHGVDVDISI FDVVTNPGQT FRGPNMTIFY SSQLGTYPYY 100
TSAGEPVFGG LPQNASLNAH LARTFQDILA AMPEPRFSGL AVIDWEAWRP 150
RWAFNWDTKD IYRQRSRALV QKQHPDWLAP RVEAAAQDQF EGAAEEWMAG 200
TLKLGQALRP QGLWGFYNFP ECYNYDFKSP NYTGRCPLNI CAQNDQLGWL 250
WGQSRALYPS IYLPAALEGT KKTQMFVQHR VAEAFRVAAG AGDPKLPVLP 300
YMQLFYDMTN HFLPAEELEH SLGESAAQGA AGVVLWVSWL STSTKESCQA 350
IKEYVDTTLG PSILNVTSGA RLCSQVLCSG HGRCARRPSY PKARLILNST 400
SFSIKPTPGG GPLTLQGALS LEDRLRMAVE FECRCYRGWR GTRCEQWGMW 450
Length:450
Mass (Da):50,508
Last modified:March 15, 2005 - v1
Checksum:i576DD38745585AB5
GO

Sequence cautioni

The sequence AAX08792.1 differs from that shown. Reason: Frameshift at position 139.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti333 – 3331V → L in AAI02474. 1 Publication
Sequence conflicti449 – 4491M → L in AAI02474. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020775 mRNA. Translation: AAX08792.1. Frameshift.
BT021035 mRNA. Translation: AAX09052.1.
BC102473 mRNA. Translation: AAI02474.1.
RefSeqiNP_001017941.1. NM_001017941.1.
UniGeneiBt.4740.

Genome annotation databases

GeneIDi515397.
KEGGibta:515397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020775 mRNA. Translation: AAX08792.1 . Frameshift.
BT021035 mRNA. Translation: AAX09052.1 .
BC102473 mRNA. Translation: AAI02474.1 .
RefSeqi NP_001017941.1. NM_001017941.1.
UniGenei Bt.4740.

3D structure databases

ProteinModelPortali Q5E985.
SMRi Q5E985. Positions 38-450.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000000611.

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEi Q5E985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 515397.
KEGGi bta:515397.

Organism-specific databases

CTDi 3373.

Phylogenomic databases

eggNOGi NOG77606.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q5E985.
KOi K01197.

Enzyme and pathway databases

Reactomei REACT_217191. CS/DS degradation.
REACT_224746. Hyaluronan uptake and degradation.

Miscellaneous databases

NextBioi 20871809.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiHYAL1_BOVIN
AccessioniPrimary (citable) accession number: Q5E985
Secondary accession number(s): Q3T0A8, Q5E9Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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