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Protein

Hyaluronidase-1

Gene

HYAL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_272809. CS/DS degradation.
REACT_297354. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Gene namesi
Name:HYAL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 450415Hyaluronidase-1PRO_0000042623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 348By similarity
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi222 ↔ 236By similarity
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi373 ↔ 384By similarity
Disulfide bondi378 ↔ 433By similarity
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi435 ↔ 444By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5E985.

Expressioni

Gene expression databases

ExpressionAtlasiQ5E985. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000611.

Structurei

3D structure databases

ProteinModelPortaliQ5E985.
SMRiQ5E985. Positions 38-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 44412EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ5E985.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPFSLEVSL HLPWAMAAHL LPVCTLFLNL LSMTQGSRDP VVPNQPFTTI
60 70 80 90 100
WNANTEWCMK KHGVDVDISI FDVVTNPGQT FRGPNMTIFY SSQLGTYPYY
110 120 130 140 150
TSAGEPVFGG LPQNASLNAH LARTFQDILA AMPEPRFSGL AVIDWEAWRP
160 170 180 190 200
RWAFNWDTKD IYRQRSRALV QKQHPDWLAP RVEAAAQDQF EGAAEEWMAG
210 220 230 240 250
TLKLGQALRP QGLWGFYNFP ECYNYDFKSP NYTGRCPLNI CAQNDQLGWL
260 270 280 290 300
WGQSRALYPS IYLPAALEGT KKTQMFVQHR VAEAFRVAAG AGDPKLPVLP
310 320 330 340 350
YMQLFYDMTN HFLPAEELEH SLGESAAQGA AGVVLWVSWL STSTKESCQA
360 370 380 390 400
IKEYVDTTLG PSILNVTSGA RLCSQVLCSG HGRCARRPSY PKARLILNST
410 420 430 440 450
SFSIKPTPGG GPLTLQGALS LEDRLRMAVE FECRCYRGWR GTRCEQWGMW
Length:450
Mass (Da):50,508
Last modified:March 15, 2005 - v1
Checksum:i576DD38745585AB5
GO

Sequence cautioni

The sequence AAX08792.1 differs from that shown. Reason: Frameshift at position 139. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti333 – 3331V → L in AAI02474 (Ref. 2) Curated
Sequence conflicti449 – 4491M → L in AAI02474 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020775 mRNA. Translation: AAX08792.1. Frameshift.
BT021035 mRNA. Translation: AAX09052.1.
BC102473 mRNA. Translation: AAI02474.1.
RefSeqiNP_001017941.1. NM_001017941.1.
UniGeneiBt.4740.

Genome annotation databases

GeneIDi515397.
KEGGibta:515397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020775 mRNA. Translation: AAX08792.1. Frameshift.
BT021035 mRNA. Translation: AAX09052.1.
BC102473 mRNA. Translation: AAI02474.1.
RefSeqiNP_001017941.1. NM_001017941.1.
UniGeneiBt.4740.

3D structure databases

ProteinModelPortaliQ5E985.
SMRiQ5E985. Positions 38-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000611.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEiQ5E985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi515397.
KEGGibta:515397.

Organism-specific databases

CTDi3373.

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ5E985.
KOiK01197.

Enzyme and pathway databases

ReactomeiREACT_272809. CS/DS degradation.
REACT_297354. Hyaluronan uptake and degradation.

Miscellaneous databases

NextBioi20871809.

Gene expression databases

ExpressionAtlasiQ5E985. baseline.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiHYAL1_BOVIN
AccessioniPrimary (citable) accession number: Q5E985
Secondary accession number(s): Q3T0A8, Q5E9Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 15, 2005
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.