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Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Gene namesi
Name:TPT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 12, Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Translationally-controlled tumor proteinPRO_0000211267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine; by PLK1By similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei64 – 641Phosphoserine; by PLK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E984.
PRIDEiQ5E984.

Expressioni

Gene expression databases

ExpressionAtlasiQ5E984. baseline.

Interactioni

Subunit structurei

Interacts with STEAP3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053875.

Structurei

3D structure databases

ProteinModelPortaliQ5E984.
SMRiQ5E984. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTP family.Curated

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiQ5E984.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REVADGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPYM IFFKDGLEME KC
Length:172
Mass (Da):19,581
Last modified:March 15, 2005 - v1
Checksum:iECDE3985802DFFD0
GO

Sequence cautioni

The sequence BAC56439.1 differs from that shown. Reason: Frameshift at positions 24 and 117. Curated
The sequence BAC56506.1 differs from that shown. Reason: Frameshift at position 118. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021036 mRNA. Translation: AAX09053.1.
BC104562 mRNA. Translation: AAI04563.1.
AB098949 mRNA. Translation: BAC56439.1. Frameshift.
AB099016 mRNA. Translation: BAC56506.1. Frameshift.
AB099031 mRNA. Translation: BAC56521.1.
RefSeqiNP_001014410.1. NM_001014388.1.
UniGeneiBt.7776.

Genome annotation databases

EnsembliENSBTAT00000013402; ENSBTAP00000013402; ENSBTAG00000010156.
ENSBTAT00000065799; ENSBTAP00000053875; ENSBTAG00000048229.
GeneIDi326599.
KEGGibta:326599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021036 mRNA. Translation: AAX09053.1.
BC104562 mRNA. Translation: AAI04563.1.
AB098949 mRNA. Translation: BAC56439.1. Frameshift.
AB099016 mRNA. Translation: BAC56506.1. Frameshift.
AB099031 mRNA. Translation: BAC56521.1.
RefSeqiNP_001014410.1. NM_001014388.1.
UniGeneiBt.7776.

3D structure databases

ProteinModelPortaliQ5E984.
SMRiQ5E984. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053875.

Proteomic databases

PaxDbiQ5E984.
PRIDEiQ5E984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013402; ENSBTAP00000013402; ENSBTAG00000010156.
ENSBTAT00000065799; ENSBTAP00000053875; ENSBTAG00000048229.
GeneIDi326599.
KEGGibta:326599.

Organism-specific databases

CTDi7178.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiQ5E984.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
TreeFamiTF300238.

Miscellaneous databases

NextBioi20809661.

Gene expression databases

ExpressionAtlasiQ5E984. baseline.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray."
    Ishiwata H., Katsuma S., Kizaki K., Patel O.V., Nakano H., Takahashi T., Imai K., Hirasawa A., Shiojima S., Ikawa H., Suzuki Y., Tsujimoto G., Izaike Y., Todoroki J., Hashizume K.
    Mol. Reprod. Dev. 65:9-18(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-155.

Entry informationi

Entry nameiTCTP_BOVIN
AccessioniPrimary (citable) accession number: Q5E984
Secondary accession number(s): Q3SX12
, Q862G3, Q862H4, Q862N1, Q862X2, Q862Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 15, 2005
Last modified: December 9, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.