Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Gene namesi
Name:TPT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 12, Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112671 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by PLK1By similarity1
Modified residuei53PhosphoserineBy similarity1
Modified residuei64Phosphoserine; by PLK1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E984.
PeptideAtlasiQ5E984.
PRIDEiQ5E984.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010156.
ExpressionAtlasiQ5E984. differential.

Interactioni

Subunit structurei

Interacts with STEAP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053875.

Structurei

3D structure databases

ProteinModelPortaliQ5E984.
SMRiQ5E984.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiQ5E984.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REVADGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPYM IFFKDGLEME KC
Length:172
Mass (Da):19,581
Last modified:March 15, 2005 - v1
Checksum:iECDE3985802DFFD0
GO

Sequence cautioni

The sequence BAC56439 differs from that shown. Reason: Frameshift at positions 24 and 117.Curated
The sequence BAC56506 differs from that shown. Reason: Frameshift at position 118.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021036 mRNA. Translation: AAX09053.1.
BC104562 mRNA. Translation: AAI04563.1.
AB098949 mRNA. Translation: BAC56439.1. Frameshift.
AB099016 mRNA. Translation: BAC56506.1. Frameshift.
AB099031 mRNA. Translation: BAC56521.1.
RefSeqiNP_001014410.1. NM_001014388.1.
UniGeneiBt.7776.

Genome annotation databases

EnsembliENSBTAT00000013402; ENSBTAP00000013402; ENSBTAG00000010156.
ENSBTAT00000065799; ENSBTAP00000053875; ENSBTAG00000048229.
GeneIDi326599.
KEGGibta:326599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021036 mRNA. Translation: AAX09053.1.
BC104562 mRNA. Translation: AAI04563.1.
AB098949 mRNA. Translation: BAC56439.1. Frameshift.
AB099016 mRNA. Translation: BAC56506.1. Frameshift.
AB099031 mRNA. Translation: BAC56521.1.
RefSeqiNP_001014410.1. NM_001014388.1.
UniGeneiBt.7776.

3D structure databases

ProteinModelPortaliQ5E984.
SMRiQ5E984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053875.

Proteomic databases

PaxDbiQ5E984.
PeptideAtlasiQ5E984.
PRIDEiQ5E984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013402; ENSBTAP00000013402; ENSBTAG00000010156.
ENSBTAT00000065799; ENSBTAP00000053875; ENSBTAG00000048229.
GeneIDi326599.
KEGGibta:326599.

Organism-specific databases

CTDi7178.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiQ5E984.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
TreeFamiTF300238.

Gene expression databases

BgeeiENSBTAG00000010156.
ExpressionAtlasiQ5E984. differential.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_BOVIN
AccessioniPrimary (citable) accession number: Q5E984
Secondary accession number(s): Q3SX12
, Q862G3, Q862H4, Q862N1, Q862X2, Q862Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.