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Protein

60S ribosomal protein L18

Gene

RPL18

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18
Gene namesi
Name:RPL18
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 18818760S ribosomal protein L18PRO_0000240141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei158 – 1581PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E973.
PeptideAtlasiQ5E973.
PRIDEiQ5E973.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020452.

Structurei

3D structure databases

ProteinModelPortaliQ5E973.
SMRiQ5E973. Positions 20-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L18e family.Curated

Phylogenomic databases

eggNOGiKOG1714. Eukaryota.
COG1727. LUCA.
GeneTreeiENSGT00390000012976.
HOGENOMiHOG000213425.
HOVERGENiHBG000875.
InParanoidiQ5E973.
KOiK02883.
OMAiIRIQDIP.
OrthoDBiEOG7PS1GP.
TreeFamiTF300202.

Family and domain databases

InterProiIPR000039. Ribosomal_L18e.
IPR021131. Ribosomal_L18e/L15P.
IPR021132. Ribosomal_L18e_CS.
[Graphical view]
PANTHERiPTHR10934. PTHR10934. 1 hit.
PfamiPF17135. Ribosomal_L18. 1 hit.
[Graphical view]
SUPFAMiSSF52080. SSF52080. 1 hit.
PROSITEiPS01106. RIBOSOMAL_L18E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR
60 70 80 90 100
LFMSRTNRPP LSLSRMIRKM KLPGREGKTA VVVGTITDDV RVQEVPKLKV
110 120 130 140 150
CALRVSSRAR SRILKAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR
160 170 180
HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
Length:188
Mass (Da):21,535
Last modified:January 23, 2007 - v3
Checksum:i1C0B31DFEA4A5CD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021047 mRNA. Translation: AAX09064.1.
BC104507 mRNA. Translation: AAI04508.1.
RefSeqiNP_001015556.1. NM_001015556.2.
UniGeneiBt.4842.

Genome annotation databases

EnsembliENSBTAT00000020452; ENSBTAP00000020452; ENSBTAG00000015388.
GeneIDi509163.
KEGGibta:509163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021047 mRNA. Translation: AAX09064.1.
BC104507 mRNA. Translation: AAI04508.1.
RefSeqiNP_001015556.1. NM_001015556.2.
UniGeneiBt.4842.

3D structure databases

ProteinModelPortaliQ5E973.
SMRiQ5E973. Positions 20-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020452.

Proteomic databases

PaxDbiQ5E973.
PeptideAtlasiQ5E973.
PRIDEiQ5E973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020452; ENSBTAP00000020452; ENSBTAG00000015388.
GeneIDi509163.
KEGGibta:509163.

Organism-specific databases

CTDi6141.

Phylogenomic databases

eggNOGiKOG1714. Eukaryota.
COG1727. LUCA.
GeneTreeiENSGT00390000012976.
HOGENOMiHOG000213425.
HOVERGENiHBG000875.
InParanoidiQ5E973.
KOiK02883.
OMAiIRIQDIP.
OrthoDBiEOG7PS1GP.
TreeFamiTF300202.

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Family and domain databases

InterProiIPR000039. Ribosomal_L18e.
IPR021131. Ribosomal_L18e/L15P.
IPR021132. Ribosomal_L18e_CS.
[Graphical view]
PANTHERiPTHR10934. PTHR10934. 1 hit.
PfamiPF17135. Ribosomal_L18. 1 hit.
[Graphical view]
SUPFAMiSSF52080. SSF52080. 1 hit.
PROSITEiPS01106. RIBOSOMAL_L18E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiRL18_BOVIN
AccessioniPrimary (citable) accession number: Q5E973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.