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Protein

60S ribosomal protein L18

Gene

RPL18

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18
Gene namesi
Name:RPL18
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002401411 – 18860S ribosomal protein L18Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei130PhosphoserineBy similarity1
Modified residuei158PhosphothreonineBy similarity1
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5E973.
PeptideAtlasiQ5E973.
PRIDEiQ5E973.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015388.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020452.

Structurei

3D structure databases

ProteinModelPortaliQ5E973.
SMRiQ5E973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1714. Eukaryota.
COG1727. LUCA.
GeneTreeiENSGT00390000012976.
HOGENOMiHOG000213425.
HOVERGENiHBG000875.
InParanoidiQ5E973.
KOiK02883.
OMAiKHHVKKG.
OrthoDBiEOG091G07WU.
TreeFamiTF300202.

Family and domain databases

InterProiView protein in InterPro
IPR036227. L18e/L15P_sf.
IPR000039. Ribosomal_L18e.
IPR021131. Ribosomal_L18e/L15P.
IPR021132. Ribosomal_L18e_CS.
PANTHERiPTHR10934. PTHR10934. 1 hit.
PfamiView protein in Pfam
PF17135. Ribosomal_L18. 1 hit.
SUPFAMiSSF52080. SSF52080. 1 hit.
PROSITEiView protein in PROSITE
PS01106. RIBOSOMAL_L18E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR
60 70 80 90 100
LFMSRTNRPP LSLSRMIRKM KLPGREGKTA VVVGTITDDV RVQEVPKLKV
110 120 130 140 150
CALRVSSRAR SRILKAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR
160 170 180
HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
Length:188
Mass (Da):21,535
Last modified:January 23, 2007 - v3
Checksum:i1C0B31DFEA4A5CD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021047 mRNA. Translation: AAX09064.1.
BC104507 mRNA. Translation: AAI04508.1.
RefSeqiNP_001015556.1. NM_001015556.2.
UniGeneiBt.4842.

Genome annotation databases

EnsembliENSBTAT00000020452; ENSBTAP00000020452; ENSBTAG00000015388.
GeneIDi509163.
KEGGibta:509163.

Similar proteinsi

Entry informationi

Entry nameiRL18_BOVIN
AccessioniPrimary (citable) accession number: Q5E973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families