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Reviewed, UniProtKB/Swiss-Prot Q5E968 (CATK_BOVIN)

Last modified January 19, 2010. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cathepsin K
    EC=3.4.22.38
Gene names
Name: CTSK
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activity

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

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Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Propeptide16 – 11499Activation peptide
PRO_0000236236
Chain115 – 329215Cathepsin K
PRO_0000236237

Sites

Active site1391 By similarity
Active site2761 By similarity
Active site2961 By similarity

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Disulfide bond136 ↔ 177 By similarity
Disulfide bond170 ↔ 210 By similarity
Disulfide bond269 ↔ 318 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5E968-1 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: A459B4651A3F8B2C

FASTA32936,947
        10         20         30         40         50         60 
MWGLTVLLLP VVSFALYPEE ILDTQWELWK KTYRKQYNSK GDEISRRLIW EKNLKHISIH 

        70         80         90        100        110        120 
NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLKVPASRS RSNDTLYIPD WEGRAPDSVD 

       130        140        150        160        170        180 
YRKKGYVTPV KNQGQCGSCW AFSSVGALEG QLKKKTGKLL NLSPQNLVDC VSENDGCGGG 

       190        200        210        220        230        240 
YMTNAFQYVQ KNRGIDSEDA YPYVGQDENC MYNPTGKAAK CRGYREIPEG NEKALKRAVA 

       250        260        270        280        290        300 
RVGPISVAID ASLTSFQFYR KGVYYDENCN SDNLNHAVLA VGYGIQKGNK HWIIKNSWGE 

       310        320 
NWGNKGYILM ARNKNNACGI ANLASFPKM

« Hide

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT021052 mRNA. Translation: AAX09069.1. Different initiation.
BC109853 mRNA. Translation: AAI09854.1. Different initiation.
IPIIPI00709374.
RefSeqNP_001029607.1.
UniGeneBt.23218

3D structure databases

SMRQ5E968. Positions 16-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5E968.

Protein family/group databases

MEROPSC01.036.

Genome annotation databases

EnsemblENSBTAT00000028016; ENSBTAP00000028016; ENSBTAG00000021035; Bos taurus. [Genome view]
GeneID513038.
KEGGbta:513038.

Organism-specific databases

CTD513038.

Phylogenomic databases

eggNOGmaNOG06335.
HOVERGENQ5E968.
InParanoidQ5E968.
OrthoDBEOG98GZNS.
PhylomeDBQ5E968.

Enzyme and pathway databases

BRENDA3.4.22.38. 251.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411:SF55. CathpsnK_like. 1 hit.
PTHR12411. Peptidase_C1A. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCATK_BOVIN
AccessionPrimary (citable) accession number: Q5E968
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: January 19, 2010
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents