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Protein

Tubulin-folding cofactor B

Gene

TBCB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-folding cofactor B
Alternative name(s):
Cytoskeleton-associated protein 1
Cytoskeleton-associated protein CKAPI
Tubulin-specific chaperone B
Gene namesi
Name:TBCB
Synonyms:CKAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:35649 TBCB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835331 – 244Tubulin-folding cofactor BAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei98PhosphotyrosineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei219N6-acetyllysineBy similarity1

Post-translational modificationi

Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.By similarity
Phosphorylation by PAK1 is required for normal function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5E951
PeptideAtlasiQ5E951
PRIDEiQ5E951

Expressioni

Gene expression databases

BgeeiENSBTAG00000015004

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Interacts with GAN. Interacts with DCTN1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019973

Structurei

3D structure databases

ProteinModelPortaliQ5E951
SMRiQ5E951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 225CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the TBCB family.Curated

Phylogenomic databases

eggNOGiKOG3206 Eukaryota
ENOG410YKGB LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000209180
HOVERGENiHBG003239
InParanoidiQ5E951
KOiK17262
OMAiYNEEEMQ
OrthoDBiEOG091G0M22
TreeFamiTF313444

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTGLSAPT VNVFISSSLN SFRSQKRYSR SLTVAEFKCK LQLVVGSPAS
60 70 80 90 100
CMELELYGPD DKFCCKLDQD DALLGSYPVD DGCRIHVIDH SGARLGEYED
110 120 130 140 150
ISKVEKYEIS QEAYEQRQDS IRSFLKRNKL GRFNEEERAQ QEAENSQRLI
160 170 180 190 200
EEEAQASTIP VGSRCEVRTP GQPPRRGTVM YVGLTDFKPG YWIGIRYDEP
210 220 230 240
LGKNDGSVNG KRYFECQAKY GAFVKPSVVT VGDFPEEDYG LDEM
Length:244
Mass (Da):27,518
Last modified:March 15, 2005 - v1
Checksum:iD135E9DA88998927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021069 mRNA Translation: AAX09086.1
BC102571 mRNA Translation: AAI02572.1
RefSeqiNP_001014939.1, NM_001014939.1
UniGeneiBt.55460

Genome annotation databases

EnsembliENSBTAT00000019973; ENSBTAP00000019973; ENSBTAG00000015004
GeneIDi530447
KEGGibta:530447

Similar proteinsi

Entry informationi

Entry nameiTBCB_BOVIN
AccessioniPrimary (citable) accession number: Q5E951
Secondary accession number(s): Q3ZCC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health