Reviewed, UniProtKB/Swiss-Prot Q5E936 (TXD12_BOVIN)

Names and origin

Protein names

Recommended name:
    Thioredoxin domain-containing protein 12
    EC=1.8.4.2

Gene names

Name:

TXNDC12

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Possesses significant protein thiol-disulfide oxidase activity By similarity.
Catalytic activity	2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein-disulfide reductase (glutathione) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 172	146	Thioredoxin domain-containing protein 12		PRO_0000233974
Regions
	Motif	169 – 172	4	Prevents secretion from ER Potential
Amino acid modifications
	Disulfide bond	66 ↔ 69		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5E936-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: BE0614789E51D437	FASTA	172	19,222
	10 20 30 40 50 60 MELRPRLGAT CLLGFSFLLL VTSSHGPNGL GKGFGDHIHW RTLEDGKKEA AASGLPLMVI 70 80 90 100 110 120 IHKSWCGACK ALKPKFAEST EISELSHNFV MVNLEDEEEP KDEDFSPDGG YIPRILFLDP 130 140 150 160 170 SGKVRPEIIN ENGNPSYKYF YISAEQVVQG MKEAQERLTG DAFREKHLED EL

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT021084 mRNA. Translation: AAX09101.1. BC102314 mRNA. Translation: AAI02315.1.
IPI	IPI00694453.
RefSeq	NP_001015536.1.
UniGene	Bt.102137
3D structure databases
SMR	Q5E936. Positions 30-163.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5E936.
Genome annotation databases
Ensembl	ENSBTAT00000014645; ENSBTAP00000014645; ENSBTAG00000011024; Bos taurus. [Genome view]
GeneID	506991.
KEGG	bta:506991.
Organism-specific databases
CTD	506991.
Phylogenomic databases
HOVERGEN	Q5E936.
OMA	CHACKAL.
Enzyme and pathway databases
BRENDA	1.8.4.2. 251.
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TXD12_BOVIN

Accession

Primary (citable) accession number: Q5E936

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)