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Q5E8U7 (GPPA_VIBF1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VF_0054
OrganismVibrio fischeri (strain ATCC 700601 / ES114) [Reference proteome] [HAMAP]
Taxonomic identifier312309 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194293

Sequences

Sequence LengthMass (Da)Tools
Q5E8U7 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 07F0B3258F73AB1B

FASTA49755,115
        10         20         30         40         50         60 
MKSSTMSPMY AAIDLGSNSF HMLVVRHING SVQTMAKIKR KVRLAAGLNE NNTLSHEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPVEN IRIVGTATLR VASNVDIFLE KANQILGHNI NVIEGEEEAR 

       130        140        150        160        170        180 
MIYQGVAHTS GGNGRRLVVD IGGASTELII GEGFEAQALT SLKMGCVTWL EGYFKDRALT 

       190        200        210        220        230        240 
QKNFNAAIAG AKETLAPILQ QYTDLGWQTC VGASGTVQAL QEIMLAQGMD EVITLAKLKR 

       250        260        270        280        290        300 
LQKQAMQYEH LEELDIDGLT LERALVFPSG LSILIAIFEL LNIDSMTLAG GALREGLCYG 

       310        320        330        340        350        360 
MIDELQHDEV CQRTIKSTQQ RYQLDVDYAQ QVTDLSIQLV QQCGNDWLIE PQALPLLTAA 

       370        380        390        400        410        420 
TQLHEIGMCI DYKKGGEHSA YLINALDLPG FTRAQKHLLG ELLRRYREYF SAMPTQHAVS 

       430        440        450        460        470        480 
DISAQRMLRI LRLAIILTHR RDVNLAPTVT LSEKNDVLSL SIDGAWLAAN PLTRSELEIE 

       490 
ADKQTNIGWE LVIDARD 

« Hide

References

[1]"Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners."
Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P.
Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700601 / ES114.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000020 Genomic DNA. Translation: AAW84549.1.
RefSeqYP_203437.1. NC_006840.2.

3D structure databases

ProteinModelPortalQ5E8U7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING312309.VF_0054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW84549; AAW84549; VF_0054.
GeneID3277951.
KEGGvfi:VF_0054.
PATRIC20110595. VBIVibFis127983_0055.

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycAFIS312309:GIWP-55-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBF1
AccessionPrimary (citable) accession number: Q5E8U7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways