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Q5E8U7

- GPPA_VIBF1

UniProt

Q5E8U7 - GPPA_VIBF1

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciAFIS312309:GIWP-55-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VF_0054
    OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
    Taxonomic identifieri312309 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000000537: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194293Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi312309.VF_0054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5E8U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5E8U7-1 [UniParc]FASTAAdd to Basket

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    MKSSTMSPMY AAIDLGSNSF HMLVVRHING SVQTMAKIKR KVRLAAGLNE    50
    NNTLSHEAMQ RGWDCLSLFA ERLQDIPVEN IRIVGTATLR VASNVDIFLE 100
    KANQILGHNI NVIEGEEEAR MIYQGVAHTS GGNGRRLVVD IGGASTELII 150
    GEGFEAQALT SLKMGCVTWL EGYFKDRALT QKNFNAAIAG AKETLAPILQ 200
    QYTDLGWQTC VGASGTVQAL QEIMLAQGMD EVITLAKLKR LQKQAMQYEH 250
    LEELDIDGLT LERALVFPSG LSILIAIFEL LNIDSMTLAG GALREGLCYG 300
    MIDELQHDEV CQRTIKSTQQ RYQLDVDYAQ QVTDLSIQLV QQCGNDWLIE 350
    PQALPLLTAA TQLHEIGMCI DYKKGGEHSA YLINALDLPG FTRAQKHLLG 400
    ELLRRYREYF SAMPTQHAVS DISAQRMLRI LRLAIILTHR RDVNLAPTVT 450
    LSEKNDVLSL SIDGAWLAAN PLTRSELEIE ADKQTNIGWE LVIDARD 497
    Length:497
    Mass (Da):55,115
    Last modified:March 15, 2005 - v1
    Checksum:i07F0B3258F73AB1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000020 Genomic DNA. Translation: AAW84549.1.
    RefSeqiYP_203437.1. NC_006840.2.

    Genome annotation databases

    EnsemblBacteriaiAAW84549; AAW84549; VF_0054.
    GeneIDi3277951.
    KEGGivfi:VF_0054.
    PATRICi20110595. VBIVibFis127983_0055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000020 Genomic DNA. Translation: AAW84549.1 .
    RefSeqi YP_203437.1. NC_006840.2.

    3D structure databases

    ProteinModelPortali Q5E8U7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 312309.VF_0054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW84549 ; AAW84549 ; VF_0054 .
    GeneIDi 3277951.
    KEGGi vfi:VF_0054.
    PATRICi 20110595. VBIVibFis127983_0055.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci AFIS312309:GIWP-55-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700601 / ES114.

    Entry informationi

    Entry nameiGPPA_VIBF1
    AccessioniPrimary (citable) accession number: Q5E8U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3