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Q5E8U7

- GPPA_VIBF1

UniProt

Q5E8U7 - GPPA_VIBF1

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-55-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VF_0054
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194293Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_0054.

Structurei

3D structure databases

ProteinModelPortaliQ5E8U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E8U7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSSTMSPMY AAIDLGSNSF HMLVVRHING SVQTMAKIKR KVRLAAGLNE
60 70 80 90 100
NNTLSHEAMQ RGWDCLSLFA ERLQDIPVEN IRIVGTATLR VASNVDIFLE
110 120 130 140 150
KANQILGHNI NVIEGEEEAR MIYQGVAHTS GGNGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAQALT SLKMGCVTWL EGYFKDRALT QKNFNAAIAG AKETLAPILQ
210 220 230 240 250
QYTDLGWQTC VGASGTVQAL QEIMLAQGMD EVITLAKLKR LQKQAMQYEH
260 270 280 290 300
LEELDIDGLT LERALVFPSG LSILIAIFEL LNIDSMTLAG GALREGLCYG
310 320 330 340 350
MIDELQHDEV CQRTIKSTQQ RYQLDVDYAQ QVTDLSIQLV QQCGNDWLIE
360 370 380 390 400
PQALPLLTAA TQLHEIGMCI DYKKGGEHSA YLINALDLPG FTRAQKHLLG
410 420 430 440 450
ELLRRYREYF SAMPTQHAVS DISAQRMLRI LRLAIILTHR RDVNLAPTVT
460 470 480 490
LSEKNDVLSL SIDGAWLAAN PLTRSELEIE ADKQTNIGWE LVIDARD
Length:497
Mass (Da):55,115
Last modified:March 15, 2005 - v1
Checksum:i07F0B3258F73AB1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84549.1.
RefSeqiWP_011260931.1. NC_006840.2.
YP_203437.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW84549; AAW84549; VF_0054.
GeneIDi3277951.
KEGGivfi:VF_0054.
PATRICi20110595. VBIVibFis127983_0055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84549.1 .
RefSeqi WP_011260931.1. NC_006840.2.
YP_203437.1. NC_006840.2.

3D structure databases

ProteinModelPortali Q5E8U7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_0054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW84549 ; AAW84549 ; VF_0054 .
GeneIDi 3277951.
KEGGi vfi:VF_0054.
PATRICi 20110595. VBIVibFis127983_0055.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci AFIS312309:GIWP-55-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiGPPA_VIBF1
AccessioniPrimary (citable) accession number: Q5E8U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3