Reviewed,
UniProtKB/Swiss-Prot Q5E840 (CYSI_VIBF1)
Last modified
February 9, 2010.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Sulfite reductase [NADPH] hemoprotein beta-component Short name=SiR-HP Short name=SiRHP EC=1.8.1.2 | ||||
| Gene names |
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| Organism | Vibrio fischeri (strain ATCC 700601 / ES114) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 312309 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio |
Protein attributes
| Sequence length | 576 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. HAMAP MF_01540 |
| Catalytic activity | H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540 |
| Cofactor | Binds 1 siroheme per subunit By similarity. HAMAP MF_01540 Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01540 |
| Pathway | Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. HAMAP MF_01540 |
| Subunit structure | Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity. HAMAP MF_01540 |
| Sequence similarities | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 576 | 576 | Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540 | PRO_0000199913 | |||||
Sites | |||||||||
| Metal binding | 439 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 445 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 485 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 489 | 1 | Iron (siroheme axial ligand) By similarity | ||||||
| Metal binding | 489 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners." Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P. Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000020 Genomic DNA. Translation: AAW84806.1. |
| RefSeq | YP_203694.1. |
3D structure databases | |
| SMR | Q5E840. Positions 85-574. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5E840. |
Genome annotation databases | |
| GeneID | 3277269. |
| GenomeReviews | Gene locus VF_0311 in contig CP000020_GR. |
| KEGG | vfi:VF_0311. |
| NMPDR | fig|312309.3.peg.311. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0155. |
| HOGENOM | HBG626671. |
| OMA | PGDNSVD. |
| PhylomeDB | Q5E840. |
Enzyme and pathway databases | |
| BioCyc | VFIS312309:VF0311-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01540. CysI. [Tree] |
| InterPro | IPR011786. CysI. IPR005117. NiRdtase/SiRdtase_haem-b_fer. IPR006067. NO2/SO3_Rdtase_4Fe4S_dom. IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS. [Graphical view] |
| Pfam | PF01077. NIR_SIR. 2 hits. PF03460. NIR_SIR_ferr. 2 hits. [Graphical view] |
| PRINTS | PR00397. SIROHAEM. |
| TIGRFAMs | TIGR02041. CysI. 1 hit. |
| PROSITE | PS00365. NIR_SIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CYSI_VIBF1 | ||||||||
| Accession | Primary (citable) accession number: Q5E840 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


