Q5E7U5 (PYRB_VIBF1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	VF_0406

Organism

Vibrio fischeri (strain ATCC 700601 / ES114)

Taxonomic identifier

312309 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113224

Sequences

	Sequence		Length	Mass (Da)
	Q5E7U5 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 94F9EFFFF34110BB	FASTA	309	34,525
	10 20 30 40 50 60 MTNSLYQKHI ISIPELSRQE LELIVETAGK IKKEPQPDLL KNKIVASCFF EASTRTRLSF 70 80 90 100 110 120 ETAIQRLGGS VIGFDTAGNT SLAQKGETLA DSVQIITSYA DAYVMRHPQE GAARLASEFS 130 140 150 160 170 180 NGTPVINAGD GANQHPTQTL LDLYTIYETQ GRLDNLNVAF VGDLKYGRTV HSLTQALAKF 190 200 210 220 230 240 EGIKFFFIAP EVLAMPDYIC EELDELGIEY QLVESMDDAI PELDILYMTR VQKERFDESE 250 260 270 280 290 300 YAHIKSAYIL SAENLQPARE NLKVLHPLPR VDEIDTDVDA TPHAYYFQQA ENGVYARQAL LALVLNETL

References

[1]

"Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners." Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P. Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700601 / ES114.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000020 Genomic DNA. Translation: AAW84901.1.
RefSeq	YP_203789.1. NC_006840.2.
3D structure databases
ProteinModelPortal	Q5E7U5.
SMR	Q5E7U5. Positions 3-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5E7U5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3278347.
GenomeReviews	Gene locus VF_0406 in contig CP000020_GR.
KEGG	vfi:VF_0406.
NMPDR	fig|312309.3.peg.406.
PATRIC	20111298. VBIVibFis127983_0396.
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	FKQSFYG.
PhylomeDB	Q5E7U5.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	VFIS312309:VF0406-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_VIBF1

Accession

Primary (citable) accession number: Q5E7U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program