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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi401 – 4088GTPUniRule annotation
Nucleotide bindingi447 – 4515GTPUniRule annotation
Nucleotide bindingi501 – 5044GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:VF_0486
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 893893Translation initiation factor IF-2PRO_0000228258Add
BLAST

Proteomic databases

PRIDEiQ5E7L5.

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_0486.

Structurei

3D structure databases

ProteinModelPortaliQ5E7L5.
SMRiQ5E7L5. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 561170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 4088G1By similarity
Regioni426 – 4305G2By similarity
Regioni447 – 4504G3By similarity
Regioni501 – 5044G4By similarity
Regioni537 – 5393G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiPMGQECG.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E7L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLTVKALS EEIGTPVDRL LQQFSDAGIN KKDGDSVTES EKQSLLVHLK
60 70 80 90 100
KEHGSVDDSA SPTRLTLQRK TRSTLSVAGS GGKSKDVQVE VRKKRTYVKA
110 120 130 140 150
SALEEEKKAE QLKAEAEEQA KRDAEEAAVR ELEQKAQREA EEQAKREAEA
160 170 180 190 200
EAKAKREAEE KAKRAEADKA KKEMTKKNEQ AKKEAEELKA RQELEATRKA
210 220 230 240 250
EAEAAKLVEE ARKLAEENEA RWKEEEQKKS AAEKDADYHV TTSSHAREAE
260 270 280 290 300
DAADRKEEQQ PRRRKKKAKP AEAAAPRGGR NQRGGRNKKA QVNKPTSMQH
310 320 330 340 350
GFDKSATVAK QDVAIGETIV VSELASKMSV KATEVIKVMM KMGAMATINQ
360 370 380 390 400
VIDQETAQLV AEEMGHKVIL RKENELEEAV LSDRDNSAEA EGRAPVVTIM
410 420 430 440 450
GHVDHGKTST LDYIRRAHVA DAEAGGITQH IGAYHVETDN GMITFLDTPG
460 470 480 490 500
HAAFTAMRAR GAQATDIVVL VVAADDGVMP QTIEAIQHAK AAGVPLIVAV
510 520 530 540 550
NKIDKEDANP DNVKNELAQY DVIPEEWGGE NMFVHISAKQ GTNIDGLLEA
560 570 580 590 600
ILLQSEVLEL TAVREGMASG VVVESRLDKG RGPVATVLVQ SGTLNKGDIV
610 620 630 640 650
LCGQEYGRVR AMRDENGKEI ESAGPSIPVE ILGLSGVPAS GDEATVVRDE
660 670 680 690 700
RKAREVANYR QGKFRDVKLA RQQKAKLENM FSNMTAGEVA ELNVVLKADV
710 720 730 740 750
QGSVEAIADS LRKLSTDEVK VNIVGSGVGG ITETDAVLAA ASNAIILGFN
760 770 780 790 800
VRADATARRT IENENLDLRY YSIIYQLIDE VKAAMGGMLA PEFKQEIIGL
810 820 830 840 850
AQVRDVFKSP KLGAIAGCMV TEGTIKRSNP IRVLRDNVVI YEGELESLRR
860 870 880 890
FKDDVAEVKN GYECGIGVKN YNDVRVGDQI EVFEIVEIKR TLD
Length:893
Mass (Da):97,555
Last modified:March 15, 2005 - v1
Checksum:i7FE41029382211C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84981.1.
RefSeqiWP_011261258.1. NC_006840.2.
YP_203869.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW84981; AAW84981; VF_0486.
GeneIDi3278169.
KEGGivfi:VF_0486.
PATRICi20111482. VBIVibFis127983_0476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84981.1.
RefSeqiWP_011261258.1. NC_006840.2.
YP_203869.1. NC_006840.2.

3D structure databases

ProteinModelPortaliQ5E7L5.
SMRiQ5E7L5. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi312309.VF_0486.

Proteomic databases

PRIDEiQ5E7L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW84981; AAW84981; VF_0486.
GeneIDi3278169.
KEGGivfi:VF_0486.
PATRICi20111482. VBIVibFis127983_0476.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiPMGQECG.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-503-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiIF2_VIBF1
AccessioniPrimary (citable) accession number: Q5E7L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 15, 2005
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.