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Q5E7L5

- IF2_VIBF1

UniProt

Q5E7L5 - IF2_VIBF1

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi401 – 4088GTPUniRule annotation
Nucleotide bindingi447 – 4515GTPUniRule annotation
Nucleotide bindingi501 – 5044GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:VF_0486
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 893893Translation initiation factor IF-2PRO_0000228258Add
BLAST

Proteomic databases

PRIDEiQ5E7L5.

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_0486.

Structurei

3D structure databases

ProteinModelPortaliQ5E7L5.
SMRiQ5E7L5. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 561170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 4088G1By similarity
Regioni426 – 4305G2By similarity
Regioni447 – 4504G3By similarity
Regioni501 – 5044G4By similarity
Regioni537 – 5393G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E7L5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLTVKALS EEIGTPVDRL LQQFSDAGIN KKDGDSVTES EKQSLLVHLK
60 70 80 90 100
KEHGSVDDSA SPTRLTLQRK TRSTLSVAGS GGKSKDVQVE VRKKRTYVKA
110 120 130 140 150
SALEEEKKAE QLKAEAEEQA KRDAEEAAVR ELEQKAQREA EEQAKREAEA
160 170 180 190 200
EAKAKREAEE KAKRAEADKA KKEMTKKNEQ AKKEAEELKA RQELEATRKA
210 220 230 240 250
EAEAAKLVEE ARKLAEENEA RWKEEEQKKS AAEKDADYHV TTSSHAREAE
260 270 280 290 300
DAADRKEEQQ PRRRKKKAKP AEAAAPRGGR NQRGGRNKKA QVNKPTSMQH
310 320 330 340 350
GFDKSATVAK QDVAIGETIV VSELASKMSV KATEVIKVMM KMGAMATINQ
360 370 380 390 400
VIDQETAQLV AEEMGHKVIL RKENELEEAV LSDRDNSAEA EGRAPVVTIM
410 420 430 440 450
GHVDHGKTST LDYIRRAHVA DAEAGGITQH IGAYHVETDN GMITFLDTPG
460 470 480 490 500
HAAFTAMRAR GAQATDIVVL VVAADDGVMP QTIEAIQHAK AAGVPLIVAV
510 520 530 540 550
NKIDKEDANP DNVKNELAQY DVIPEEWGGE NMFVHISAKQ GTNIDGLLEA
560 570 580 590 600
ILLQSEVLEL TAVREGMASG VVVESRLDKG RGPVATVLVQ SGTLNKGDIV
610 620 630 640 650
LCGQEYGRVR AMRDENGKEI ESAGPSIPVE ILGLSGVPAS GDEATVVRDE
660 670 680 690 700
RKAREVANYR QGKFRDVKLA RQQKAKLENM FSNMTAGEVA ELNVVLKADV
710 720 730 740 750
QGSVEAIADS LRKLSTDEVK VNIVGSGVGG ITETDAVLAA ASNAIILGFN
760 770 780 790 800
VRADATARRT IENENLDLRY YSIIYQLIDE VKAAMGGMLA PEFKQEIIGL
810 820 830 840 850
AQVRDVFKSP KLGAIAGCMV TEGTIKRSNP IRVLRDNVVI YEGELESLRR
860 870 880 890
FKDDVAEVKN GYECGIGVKN YNDVRVGDQI EVFEIVEIKR TLD
Length:893
Mass (Da):97,555
Last modified:March 15, 2005 - v1
Checksum:i7FE41029382211C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84981.1.
RefSeqiYP_203869.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW84981; AAW84981; VF_0486.
GeneIDi3278169.
KEGGivfi:VF_0486.
PATRICi20111482. VBIVibFis127983_0476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW84981.1 .
RefSeqi YP_203869.1. NC_006840.2.

3D structure databases

ProteinModelPortali Q5E7L5.
SMRi Q5E7L5. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_0486.

Proteomic databases

PRIDEi Q5E7L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW84981 ; AAW84981 ; VF_0486 .
GeneIDi 3278169.
KEGGi vfi:VF_0486.
PATRICi 20111482. VBIVibFis127983_0476.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi DNRTGGY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci AFIS312309:GIWP-503-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiIF2_VIBF1
AccessioniPrimary (citable) accession number: Q5E7L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3