Reviewed, UniProtKB/Swiss-Prot Q5E7B6 (ARGA_VIBF1)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	VF_0585

Organism

Vibrio fischeri (strain ATCC 700601 / ES114) [Complete proteome] [HAMAP]

Taxonomic identifier

312309 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Amino-acid acetyltransferase HAMAP MF_01105		PRO_1000137053
Regions
	Domain	299 – 438	140	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q5E7B6-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 955EB4BD2EF99CA4	FASTA	446	49,488
	10 20 30 40 50 60 MKFRSTALVK GFRQSAPYVN AHRDKTVVIM LGGEAIADPN FANIVNDIAL LNSLGLRIVI 70 80 90 100 110 120 VYGTRPQMRS LLKQTEHHAP FHKGIRITDE QTLELVKQIA GQLQLDITAR LSMSLNNTPM 130 140 150 160 170 180 AGAQINVISG NFVIAQPLGV DDGIDYCHSG RVRRIDTQGI NRMLDQQSIV LLGPVASSVT 190 200 210 220 230 240 GECFNLLSED VATQLAIRLN ADKLIGFCSE QGVLNEKGQI LAELFPSEAE EILQRLEKEL 250 260 270 280 290 300 TPENGKLTGT MRFLKGAISA CKAGVPRSHL ISYKEDGALI QELFSFDGIG TQVVMASSEQ 310 320 330 340 350 360 VRDAEIDDIG GILDLIRPLE EEGILVRRSR EQLEQEIAQF TIIEKDGLVI ACAALYPFPE 370 380 390 400 410 420 EGMAEMGCVA VHPDYRDGDR GVTLLNRLRS KAKQFKLSQL FVLTTRSLHW FREQGFIEVD 430 440 VSHLPIKKQK LYNFQRKSKI LVLKGL

References

[1]

"Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners." Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P. Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000020 Genomic DNA. Translation: AAW85080.1.
RefSeq	YP_203968.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5E7B6.
Genome annotation databases
GeneID	3277126.
GenomeReviews	Gene locus VF_0585 in contig CP000020_GR.
KEGG	vfi:VF_0585.
NMPDR	fig|312309.3.peg.682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5E7B6.
OMA	DLIRPLE.
Enzyme and pathway databases
BioCyc	VFIS312309:VF0585-MON.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_VIBF1

Accession

Primary (citable) accession number: Q5E7B6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)