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Protein

Alanine racemase

Gene

VF_0735

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (VF_0735), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei170SubstrateUniRule annotation1
Active sitei296Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei344Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-768-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:VF_0735Imported
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)Imported
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500425555121 – 403Alanine racemaseSequence analysisAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_0735

Structurei

3D structure databases

ProteinModelPortaliQ5E6W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 403Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000279190
KOiK01775
OMAiYSDGYRR
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E6W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTKCALAL SLALPSIANS APLLSLDTLT NQEKIQQTNA WLEIDTQAFQ
60 70 80 90 100
NNIDTLRASL EQDTKVCAIM KADAYGNGIE GLMASVIERN VECIGITSNE
110 120 130 140 150
EARIVRAKGF VGELMRVRAA SPNEIESGLQ YKIEELIGSS EQANIIAKLA
160 170 180 190 200
KQNNTIIPVH LALNAGGMGR NGLDLSQPQG KKEALNIAFN GHVNIVGIMT
210 220 230 240 250
HFPNESVDEI RTKLNLFKQE SQWLIDEAQL NRDDITLHVA NSYTTINLPE
260 270 280 290 300
AHLDMVRPGG LLYGDMPNNP EYKRIVQFKT SVASLNYLPK GSTIGYSSTY
310 320 330 340 350
VLGRDSILAN LPLGYSDGYV RSIGNNGYVL INGQKANVVG VTSMNTTMVD
360 370 380 390 400
ITDIKNVQPG DEVVLFGKQN EFTIEAKEME AFSSRSMPEL YVIWGSTNPK

IYK
Length:403
Mass (Da):44,248
Last modified:March 15, 2005 - v1
Checksum:iDD94B7C66EAD39D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA Translation: AAW85230.1
RefSeqiWP_011261446.1, NC_006840.2
YP_204118.1, NC_006840.2

Genome annotation databases

EnsemblBacteriaiAAW85230; AAW85230; VF_0735
GeneIDi3277953
KEGGivfi:VF_0735
PATRICifig|312309.11.peg.728

Similar proteinsi

Entry informationi

Entry nameiQ5E6W6_VIBF1
AccessioniPrimary (citable) accession number: Q5E6W6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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