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Q5E638

- HISX_VIBF1

UniProt

Q5E638 - HISX_VIBF1

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Protein
Histidinol dehydrogenase
Gene
hisD, VF_1013
Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei323 – 3231Proton acceptor By similarity
Active sitei324 – 3241Proton acceptor By similarity
Binding sitei324 – 3241Substrate By similarity
Metal bindingi357 – 3571Zinc By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei411 – 4111Substrate By similarity
Metal bindingi416 – 4161Zinc By similarity
Binding sitei416 – 4161Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-1069-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:VF_1013
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Histidinol dehydrogenaseUniRule annotation
PRO_0000135875Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_1013.

Structurei

3D structure databases

ProteinModelPortaliQ5E638.
SMRiQ5E638. Positions 6-429.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E638-1 [UniParc]FASTAAdd to Basket

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MKTLVWQSLS DSQQDTVLQR PAITEGANIT AAVTSVINTV KQEGDAGVFA    50
LTEKFDGVKP DSIRVSNAEI EAASDRLSEE MKTALKQAYS NISKFHQAQK 100
PQPVKVETQP GVICEQITMP INKVGLYIPG GSAPLPSTVL MLGIPAQIAG 150
CHKVVLCSPP PIADEILYVA KLCKIDEVYN IGGAQAVAAM AYGTESVSKV 200
DKIFGPGNAY VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DESADPDFIA 250
ADLLSQAEHG PDSQVVLVTP SPIIADQVAD AVERQLKELS REDIARQALG 300
SSLLIVADSL TQCVSISNFY GPEHLIVQTK NPRELLPLLD NAGSIFLGDY 350
SPESAGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELTADGLKGL 400
APTVVTMAEA EGLDAHKRAV TIRIEKLAQL DVNKQEVNQ 439
Length:439
Mass (Da):46,846
Last modified:March 15, 2005 - v1
Checksum:i83ABB202021C0078
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000020 Genomic DNA. Translation: AAW85508.1.
RefSeqiYP_204396.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW85508; AAW85508; VF_1013.
GeneIDi3277807.
KEGGivfi:VF_1013.
PATRICi20112620. VBIVibFis127983_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000020 Genomic DNA. Translation: AAW85508.1 .
RefSeqi YP_204396.1. NC_006840.2.

3D structure databases

ProteinModelPortali Q5E638.
SMRi Q5E638. Positions 6-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_1013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW85508 ; AAW85508 ; VF_1013 .
GeneIDi 3277807.
KEGGi vfi:VF_1013.
PATRICi 20112620. VBIVibFis127983_1013.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci AFIS312309:GIWP-1069-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiHISX_VIBF1
AccessioniPrimary (citable) accession number: Q5E638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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