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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Zinc1
Metal bindingi32Zinc1
Metal bindingi48Zinc1
Metal bindingi51Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Ordered Locus Names:VF_1695
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003590861 – 294Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST294

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Protein-protein interaction databases

STRINGi312309.VF_1695.

Structurei

3D structure databases

ProteinModelPortaliQ5E456.
SMRiQ5E456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 294CoA carboxyltransferase N-terminalAdd BLAST270

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
HOGENOMiHOG000021670.
KOiK01963.
OMAiPEGLWIK.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWLEKIFNT SNIVSSRKAS IPEGVWTKCT SCEQVLYSAE LERNLEVCPK
60 70 80 90 100
CDHHMRMKAR KRLETFLDAE GRVEIGAELE PKDVLKFKDS KRYKDRISAA
110 120 130 140 150
QKSSEETDAL VVMKGTLLEL PVVACAFEFS FMGGSMGSVV GARFVKAVDA
160 170 180 190 200
AIENNCPLVC FSASGGARMQ EALMSLMQMA KTSAALARLS RKGLPFFSVL
210 220 230 240 250
TDPTMGGVSA SLAMLGDINI GEPKALIGFA GRRVIEQTVR EDLPEGFQRS
260 270 280 290
EFLLEHGAID MIVDRREMRQ RIGGLMAKMT NQESPLVVPV DGSH
Length:294
Mass (Da):32,316
Last modified:March 15, 2005 - v1
Checksum:i3FCE79E5179BC05C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW86190.1.
RefSeqiWP_011262249.1. NC_006840.2.
YP_205078.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW86190; AAW86190; VF_1695.
GeneIDi3277672.
KEGGivfi:VF_1695.
PATRICifig|312309.11.peg.1717.

Similar proteinsi

Entry informationi

Entry nameiACCD_VIBF1
AccessioniPrimary (citable) accession number: Q5E456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: March 15, 2005
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families