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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-1893-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VF_1793
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994081 – 582Formate--tetrahydrofolate ligaseAdd BLAST582

Proteomic databases

PRIDEiQ5E3V8

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_1793

Structurei

3D structure databases

ProteinModelPortaliQ5E3V8
SMRiQ5E3V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E3V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEICQT ATLTRMKTIA SNLGLHDDDI TPQGPFKAKV NIDALKRLKS
60 70 80 90 100
EPNGKLILVS AITPTPLGEG KTVTTIGLAQ GLAKLGESVS ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAITAAHNLA SAAIDARIYH
160 170 180 190 200
EQRLGYDVFS EKNELPALRI DPQHVVWKRV MDHNDRALRM VTIGKNEDGK
210 220 230 240 250
TINGYEREDG FDITAASELM AILALATDLQ DLRQRIGRIV VAYNLDGEPV
260 270 280 290 300
TTEDLQVAGA MTVTMKFAIN PTLMQTLEGV PTFVHSGPFA NIAHGNSSII
310 320 330 340 350
ADNIALKLTD YTVTEGGFGS DMGFEKACNI KAPLSEKSPD CAVLVATLRG
360 370 380 390 400
IKANSGLFPL SPGQSLPKEL FAPNKEALDA GLDNLLWHIN NCAKYGLPVV
410 420 430 440 450
VAINRFPEDT QEELDSLLNW VSNLDMNVDV AISEAFVKGG NGTLELAEKV
460 470 480 490 500
IKACQQETQF TPLYTSEMSL FDKLNAVAIK GYGAERIELS EKAQQQLATF
510 520 530 540 550
EKLGYQSLSV CMAKTPASIS TDGNIKGAPT DFIVPIRELK LCAGAGFIYA
560 570 580
LCGNVMTMPG LPEKPAFMNL DIDGDGNIVG LS
Length:582
Mass (Da):62,388
Last modified:March 15, 2005 - v1
Checksum:i4AEA0318FE978295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA Translation: AAW86288.1
RefSeqiWP_011262325.1, NC_006840.2
YP_205176.1, NC_006840.2

Genome annotation databases

EnsemblBacteriaiAAW86288; AAW86288; VF_1793
GeneIDi3277682
KEGGivfi:VF_1793
PATRICifig|312309.11.peg.1820

Similar proteinsi

Entry informationi

Entry nameiFTHS_VIBF1
AccessioniPrimary (citable) accession number: Q5E3V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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