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Q5E3V8

- FTHS_VIBF1

UniProt

Q5E3V8 - FTHS_VIBF1

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-1896-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VF_1793
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199408Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_1793.

Structurei

3D structure databases

ProteinModelPortaliQ5E3V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E3V8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEICQT ATLTRMKTIA SNLGLHDDDI TPQGPFKAKV NIDALKRLKS
60 70 80 90 100
EPNGKLILVS AITPTPLGEG KTVTTIGLAQ GLAKLGESVS ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAITAAHNLA SAAIDARIYH
160 170 180 190 200
EQRLGYDVFS EKNELPALRI DPQHVVWKRV MDHNDRALRM VTIGKNEDGK
210 220 230 240 250
TINGYEREDG FDITAASELM AILALATDLQ DLRQRIGRIV VAYNLDGEPV
260 270 280 290 300
TTEDLQVAGA MTVTMKFAIN PTLMQTLEGV PTFVHSGPFA NIAHGNSSII
310 320 330 340 350
ADNIALKLTD YTVTEGGFGS DMGFEKACNI KAPLSEKSPD CAVLVATLRG
360 370 380 390 400
IKANSGLFPL SPGQSLPKEL FAPNKEALDA GLDNLLWHIN NCAKYGLPVV
410 420 430 440 450
VAINRFPEDT QEELDSLLNW VSNLDMNVDV AISEAFVKGG NGTLELAEKV
460 470 480 490 500
IKACQQETQF TPLYTSEMSL FDKLNAVAIK GYGAERIELS EKAQQQLATF
510 520 530 540 550
EKLGYQSLSV CMAKTPASIS TDGNIKGAPT DFIVPIRELK LCAGAGFIYA
560 570 580
LCGNVMTMPG LPEKPAFMNL DIDGDGNIVG LS
Length:582
Mass (Da):62,388
Last modified:March 15, 2005 - v1
Checksum:i4AEA0318FE978295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW86288.1.
RefSeqiWP_011262325.1. NC_006840.2.
YP_205176.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW86288; AAW86288; VF_1793.
GeneIDi3277682.
KEGGivfi:VF_1793.
PATRICi20114278. VBIVibFis127983_1820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA. Translation: AAW86288.1 .
RefSeqi WP_011262325.1. NC_006840.2.
YP_205176.1. NC_006840.2.

3D structure databases

ProteinModelPortali Q5E3V8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_1793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW86288 ; AAW86288 ; VF_1793 .
GeneIDi 3277682.
KEGGi vfi:VF_1793.
PATRICi 20114278. VBIVibFis127983_1820.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci AFIS312309:GIWP-1896-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiFTHS_VIBF1
AccessioniPrimary (citable) accession number: Q5E3V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3