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Q5E3F2

- LPXB_VIBF1

UniProt

Q5E3F2 - LPXB_VIBF1

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-2051-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:VF_1949
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_0000255231Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_1949.

Structurei

3D structure databases

ProteinModelPortaliQ5E3F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E3F2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPLRIGIV AGELSGDTLG EGFIKSIKAQ YPDAEFVGIG GPKMIAQGCD
60 70 80 90 100
SLFDMEELAV MGLVEVLGRL PRLLKVKAEL VRYFTQNPPD VFIGIDAPDF
110 120 130 140 150
NLRLEKTLKD NGIKTVHYVS PSVWAWRPKR IFKIDAATDL VLAFLPFEKA
160 170 180 190 200
FYDKYNVACE FIGHTLADAI PMETDKIAAR DLLGLEQERE WLAVLPGSRG
210 220 230 240 250
GEVALIAKPF IETCQRIHKQ HPNMGFVVAA VNEKRREQFE TIWKATAPEL
260 270 280 290 300
DFVIIQDTAR NVMTAADAVL LASGTVALEC MLVKRPMVVG YQVNKLTGWI
310 320 330 340 350
AQKLSITEFV SLPNVLAGKE LVQEFIQEEC HPDFLYPAME KVLNNDNREL
360 370 380
IEKFTEMHQW IRKDADKQAA NAVLRLINKE TAE
Length:383
Mass (Da):42,958
Last modified:March 15, 2005 - v1
Checksum:i13B1974E02CA9BD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000020 Genomic DNA. Translation: AAW86444.1.
RefSeqiYP_205332.1. NC_006840.2.

Genome annotation databases

EnsemblBacteriaiAAW86444; AAW86444; VF_1949.
GeneIDi3279112.
KEGGivfi:VF_1949.
PATRICi20114590. VBIVibFis127983_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000020 Genomic DNA. Translation: AAW86444.1 .
RefSeqi YP_205332.1. NC_006840.2.

3D structure databases

ProteinModelPortali Q5E3F2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_1949.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW86444 ; AAW86444 ; VF_1949 .
GeneIDi 3279112.
KEGGi vfi:VF_1949.
PATRICi 20114590. VBIVibFis127983_1976.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AFIS312309:GIWP-2051-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiLPXB_VIBF1
AccessioniPrimary (citable) accession number: Q5E3F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3