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Protein

NAD kinase

Gene

nadK

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei77Proton acceptorUniRule annotation1
Binding sitei162NADUniRule annotation1
Binding sitei179NADUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei252NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 78NADUniRule annotation2
Nucleotide bindingi151 – 152NADUniRule annotation2
Nucleotide bindingi192 – 197NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-2095-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:VF_1997
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297101 – 297NAD kinaseAdd BLAST297

Proteomic databases

PRIDEiQ5E3A4

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_1997

Structurei

3D structure databases

ProteinModelPortaliQ5E3A4
SMRiQ5E3A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E3A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDMKRAFNV IAIIGKPRDP NAIKTHLSIY HWLTDQNYTV LLDDRLREAL
60 70 80 90 100
PEIPADRFNH LLKLGELADL AIVVGGDGNM LGAARVLSRF DISVIGVNRG
110 120 130 140 150
NLGFLTDLDP DNFEEPLQAV LNGDFVKEER FLLEAEVHRH GQVKSHNSAF
160 170 180 190 200
NEVVLHPGQV AHMIEFEVYI DDTFAFSQRS DGLIISTPTG STAYSLSGGG
210 220 230 240 250
PILSPNLNAI SIVPMFPHTL SSRPLVVEGK RHIKLCISPE NRTTLEVSCD
260 270 280 290
GQVSLPVSPG DEVHIFQSPS RLKLIHPKDY SYYHILRNKL GWSSKLF
Length:297
Mass (Da):33,071
Last modified:March 15, 2005 - v1
Checksum:iEAA30205EC28070A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA Translation: AAW86492.1
RefSeqiWP_011262459.1, NC_006840.2
YP_205380.1, NC_006840.2

Genome annotation databases

EnsemblBacteriaiAAW86492; AAW86492; VF_1997
GeneIDi3279125
KEGGivfi:VF_1997
PATRICifig|312309.11.peg.2024

Similar proteinsi

Entry informationi

Entry nameiNADK_VIBF1
AccessioniPrimary (citable) accession number: Q5E3A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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