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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-2498-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:VF_2372
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354092 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Proteomic databases

PRIDEiQ5E279

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi312309.VF_2372

Structurei

3D structure databases

ProteinModelPortaliQ5E279
SMRiQ5E279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini286 – 426SIS 1UniRule annotationAdd BLAST141
Domaini459 – 600SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258898
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAVVDAE HNYTRIRRLG
60 70 80 90 100
KVKELADAVE TAHVVGGTGI AHTRWATHGE PSEVNAHPHV SGDITLVHNG
110 120 130 140 150
IIENHESLRT LLQERGYIFE SQTDTEVIAH LVEWELRSSG SLLEAVQKTA
160 170 180 190 200
TQLEGAYGTV VMDRREPERL VVARSGSPIV IGCGVGENFL ASDQLALLNV
210 220 230 240 250
TRRFMYLEEG DVAEITRREI RVFDARGEQV ERAITESNAE HDAGDKGQYR
260 270 280 290 300
HFMQKEVFEQ PKALINTMEG RITNDSVVTE SIGVNAVEIL NKVEHVQIIA
310 320 330 340 350
CGTSYNAGMT ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKERGYMG AMTVCNVAGS SLVRESDFAF MTRAGTEIGV
410 420 430 440 450
ASTKAFTTQL AALLMLVTAL GKQQNRISKE KEKEIVEALH ALPAQIEQAL
460 470 480 490 500
SFDKEIEALA PDFADKHHTL FLGRGEFYPI AVEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDAEMPVVV VAPTNDLLEK LKSNVEEVRA RGGLLYVFAD
560 570 580 590 600
EQAGFEADES MKIITMPHVS DITAPIYYTI PMQLLSYHVA LIKGTDVDQP
610
RNLAKAVTVE
Length:610
Mass (Da):67,036
Last modified:January 23, 2007 - v3
Checksum:iA13F822494667F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA Translation: AAW86867.1
RefSeqiWP_011262763.1, NC_006840.2
YP_205755.1, NC_006840.2

Genome annotation databases

EnsemblBacteriaiAAW86867; AAW86867; VF_2372
GeneIDi3279607
KEGGivfi:VF_2372
PATRICifig|312309.11.peg.2409

Entry informationi

Entry nameiGLMS_VIBF1
AccessioniPrimary (citable) accession number: Q5E279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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