Q5E1R4 (PURE_VIBF1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase
Short name=N5-CAIR mutase
EC=5.4.99.18

Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase

Gene names

Name:	purE
Ordered Locus Names:	VF_2537

Organism

Vibrio fischeri (strain ATCC 700601 / ES114)

Taxonomic identifier

312309 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	N5-carboxyaminoimidazole ribonucleotide mutase		PRO_0000074982
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	12	1	Substrate By similarity
	Binding site	39	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5E1R4 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 8E4E4D33F56002CE	FASTA	161	16,773
	10 20 30 40 50 60 MKVGIIMGSK SDWPTMKLAA EMLDRFNVPY ETKVVSAHRT PQLLADYATQ AKDRGIKVII 70 80 90 100 110 120 AGAGGAAHLP GMAAAFTSVP VLGVPVQSRA LKGMDSLLSI VQMPKGIAVG TLAIGEAGAA 130 140 150 160 NAGILAAQII GTSNEEVMAA VEAFRKEQTE MVLENPDPSE D

References

[1]

"Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners." Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P. Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700601 / ES114.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000020 Genomic DNA. Translation: AAW87032.1.
RefSeq	YP_205920.1. NC_006840.2.
3D structure databases
ProteinModelPortal	Q5E1R4.
SMR	Q5E1R4. Positions 3-150.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5E1R4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3279682.
GenomeReviews	Gene locus VF_2537 in contig CP000020_GR.
KEGG	vfi:VF_2537.
NMPDR	fig|312309.3.peg.2537.
PATRIC	20115894. VBIVibFis127983_2563.
Phylogenomic databases
eggNOG	COG0041.
HOGENOM	HBG301965.
OMA	LIMGSDS.
PhylomeDB	Q5E1R4.
ProtClustDB	CLSK2396259.
Enzyme and pathway databases
BioCyc	VFIS312309:VF2537-MONOMER.
Family and domain databases
InterPro	IPR024694. N5-CAIR_mutase_PurE. IPR000031. N5-CAIR_Mutase_PurE_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
KO	K01588.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
PIRSF	PIRSF001338. AIR_carboxylase. 1 hit.
SMART	SM01001. AIRC. 1 hit. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 1 hit.
TIGRFAMs	TIGR01162. PurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PURE_VIBF1

Accession

Primary (citable) accession number: Q5E1R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program