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Q5E1R3 (PURK_VIBF1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide synthase

Short name=N5-CAIR synthase
EC=6.3.4.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene names
Name:purK
Ordered Locus Names:VF_2538
OrganismVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifier312309 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purK/purT family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370N5-carboxyaminoimidazole ribonucleotide synthase
PRO_0000075016

Regions

Domain97 – 288192ATP-grasp
Nucleotide binding175 – 1784ATP By similarity
Nucleotide binding258 – 2592ATP By similarity

Sites

Binding site931ATP By similarity
Binding site1331ATP By similarity
Binding site1441ATP By similarity
Binding site1831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5E1R3 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 797F90E7489AD36F

FASTA37040,933
        10         20         30         40         50         60 
MNVLILGSGQ LARMMSLASA PLNIDVIAYD VNSQQIVHPL TQQPIDLSLE QAIKQVDVIT 

        70         80         90        100        110        120 
AEFEHIPHHI LDICSVSGKF QPTPDAIKAG GDRRLEKKLL DNAHVANAKY HNINTKQDFL 

       130        140        150        160        170        180 
NAIDTVGIPM VLKSALGGYD GKGQWRLKDV SQVDSIWEEM DELIKSSPNQ AIVAEQFIPF 

       190        200        210        220        230        240 
NREVSLIGAR NKNGQMVTYP LTENVHVDGV LALSTALEGT SNLQQQADEM FTAIADELNY 

       250        260        270        280        290        300 
IGVLAIEFFD VDGTLLVNEI APRVHNSGHW TQQGTDICQF EMHIRAVCNL PLTGNQLLRS 

       310        320        330        340        350        360 
TAMINILGED SLPDEILTMP NCHIHWYGKE KRAGRKMGHI NVCADSPEML QKELSKLANI 

       370 
LDKQAFKALS 

« Hide

References

[1]"Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners."
Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P.
Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700601 / ES114.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000020 Genomic DNA. Translation: AAW87033.1.
RefSeqYP_205921.1. NC_006840.2.

3D structure databases

ProteinModelPortalQ5E1R3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5E1R3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3279691.
GenomeReviewsGene locus VF_2538 in contig CP000020_GR.
KEGGvfi:VF_2538.
NMPDRfig|312309.3.peg.2538.
PATRIC20115896. VBIVibFis127983_2564.

Phylogenomic databases

eggNOGCOG0026.
HOGENOMHBG516369.
OMAGRKMGHF.
PhylomeDBQ5E1R3.
ProtClustDBPRK06019.

Enzyme and pathway databases

BioCycVFIS312309:VF2538-MONOMER.

Family and domain databases

InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
KOK01589.
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01161. PurK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURK_VIBF1
AccessionPrimary (citable) accession number: Q5E1R3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families