Reviewed,
UniProtKB/Swiss-Prot Q5E1R3 (PURK_VIBF1)
Last modified
February 9, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylaminoimidazole carboxylase ATPase subunit EC=4.1.1.21 Alternative name(s): AIR carboxylase Short name=AIRC | ||||
| Gene names |
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| Organism | Vibrio fischeri (strain ATCC 700601 / ES114) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 312309 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio |
Protein attributes
| Sequence length | 370 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition By similarity. |
| Catalytic activity | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the purK/purT family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazole carboxylase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 370 | 370 | Phosphoribosylaminoimidazole carboxylase ATPase subunit | PRO_0000075016 | |||||
Regions | |||||||||
| Domain | 97 – 288 | 192 | ATP-grasp | ||||||
| Nucleotide binding | 175 – 178 | 4 | ATP By similarity | ||||||
| Nucleotide binding | 258 – 259 | 2 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 93 | 1 | ATP By similarity | ||||||
| Binding site | 133 | 1 | ATP By similarity | ||||||
| Binding site | 144 | 1 | ATP By similarity | ||||||
| Binding site | 183 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners." Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R., Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E., Stevens A., Visick K., Whistler C., Greenberg E.P. Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005) [PubMed: 15703294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000020 Genomic DNA. Translation: AAW87033.1. |
| RefSeq | YP_205921.1. |
3D structure databases | |
| SMR | Q5E1R3. Positions 1-362. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5E1R3. |
Genome annotation databases | |
| GeneID | 3279691. |
| GenomeReviews | Gene locus VF_2538 in contig CP000020_GR. |
| KEGG | vfi:VF_2538. |
| NMPDR | fig|312309.3.peg.2538. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0026. |
| HOGENOM | HBG516369. |
| OMA | YDGKGQA. |
| PhylomeDB | Q5E1R3. |
Enzyme and pathway databases | |
| BioCyc | VFIS312309:VF2538-MONOMER. |
Family and domain databases | |
| InterPro | IPR005875. AIR_COase_ATPase-su. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR011054. Rudment_hybrid_motif. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| PANTHER | PTHR23047:SF1. PurK_ATP. 1 hit. |
| Pfam | PF02222. ATP-grasp. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01161. purK. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PURK_VIBF1 | ||||||||
| Accession | Primary (citable) accession number: Q5E1R3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


