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Q5E0Q5

- THIM_VIBF1

UniProt

Q5E0Q5 - THIM_VIBF1

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, VF_A0321
Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481Substrate; via amide nitrogen By similarity
Binding sitei124 – 1241ATP By similarity
Binding sitei170 – 1701ATP By similarity
Binding sitei197 – 1971Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-3064-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:VF_A0321
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinaseUniRule annotationPRO_0000336575Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_A0321.

Structurei

3D structure databases

ProteinModelPortaliQ5E0Q5.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E0Q5-1 [UniParc]FASTAAdd to Basket

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MTIMNIQYIV ECLALLREKK PLVVNITNYV VMNNTANALL ALGASPIMAH    50
SQQEMAEMMS FSGALVINIG TLDSVWTPRM HFAVEQANLN NKAVVLDPVG 100
CGASQLRTQV ARQIAEAANK LIIRANASEV IALAGENAQS KGVDALDSSD 150
SAVGAACYVA QKYQCSVVIS GETDYIVTQD AQYKLNNGHA MMPFVTGMGC 200
THTALTGAFA AIGDESGVVA TAVLGVAGEI AAEQSAGPGS LQMNLLDTLY 250
QLDEETLTRR LKLTVNA 267
Length:267
Mass (Da):28,181
Last modified:March 15, 2005 - v1
Checksum:iD58CF5EB05F3977F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000021 Genomic DNA. Translation: AAW87391.1.
RefSeqiYP_206279.1. NC_006841.2.

Genome annotation databases

EnsemblBacteriaiAAW87391; AAW87391; VF_A0321.
GeneIDi3280543.
KEGGivfi:VF_A0321.
PATRICi20116624. VBIVibFis127983_2925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000021 Genomic DNA. Translation: AAW87391.1 .
RefSeqi YP_206279.1. NC_006841.2.

3D structure databases

ProteinModelPortali Q5E0Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_A0321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW87391 ; AAW87391 ; VF_A0321 .
GeneIDi 3280543.
KEGGi vfi:VF_A0321.
PATRICi 20116624. VBIVibFis127983_2925.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci AFIS312309:GIWP-3064-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiTHIM_VIBF1
AccessioniPrimary (citable) accession number: Q5E0Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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