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Q5DZM3

- GCSP_VIBF1

UniProt

Q5DZM3 - GCSP_VIBF1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAFIS312309:GIWP-3455-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:VF_A0703
    OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
    Taxonomic identifieri312309 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000000537: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000045624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi312309.VF_A0703.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5DZM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5DZM3-1 [UniParc]FASTAAdd to Basket

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    MSQLLQQLGT DNEFIRRHNG PASSEHQHML NTIGAETLQQ LIEETVPSSI    50
    RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR 100
    NVLENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL EIANASLLDE 150
    ATAAAEAMTL CKRGGKSKSN LFFVADDVHP QTLAVIKTRA KFIGFDVVVD 200
    HESNLDSHDV FGALLQYPGT TGEVKDLTDL IAQAHTKKTL VIVATDLLAS 250
    VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 300
    GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH 350
    GPEGLKTIAR RVHHFTAIVA KALQTAGFEL EHQHFFDTLT VKTEQQTDIL 400
    YTKALASSIN LRKFDTKLGI SFDETTTVSD LVTLLAVFGI DNAECETLSA 450
    EVGKDEFAAI PKHCQRTSSF LTHPVFNTYH SETQMLRYLK KLENKDFSLT 500
    HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK 550
    SMLCEITGYD EFSLQPNSGA SGEYAGLIAI QRYHESRGDA HRNVCLIPSS 600
    AHGTNPATAS MVSMKVVVVK CDENGNIDMI DLAEKIEKHQ ENLSSIMITY 650
    PSTHGVYEEQ VREVCDMVHA AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH 700
    LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHTENGVQ GMDYAVSAAD 750
    LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMERL RPHYPVLYRG 800
    TNGRIAHECI IDIRPLKETT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM 850
    VEPTESEDLA ELDRFCDAMI AIREEMNKVE QGEWPLDNNP LVNAPHTQVD 900
    LMSDSWEHPY TREVACFPSS QSKDSKYWPT VNRVDNVYGD RNLICSCPSI 950
    ENYEE 955
    Length:955
    Mass (Da):104,827
    Last modified:March 15, 2005 - v1
    Checksum:iE15ED1B6CDEA05BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000021 Genomic DNA. Translation: AAW87773.1.
    RefSeqiWP_011263534.1. NC_006841.2.
    YP_206661.1. NC_006841.2.

    Genome annotation databases

    EnsemblBacteriaiAAW87773; AAW87773; VF_A0703.
    GeneIDi3280782.
    KEGGivfi:VF_A0703.
    PATRICi20117401. VBIVibFis127983_3305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000021 Genomic DNA. Translation: AAW87773.1 .
    RefSeqi WP_011263534.1. NC_006841.2.
    YP_206661.1. NC_006841.2.

    3D structure databases

    ProteinModelPortali Q5DZM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 312309.VF_A0703.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW87773 ; AAW87773 ; VF_A0703 .
    GeneIDi 3280782.
    KEGGi vfi:VF_A0703.
    PATRICi 20117401. VBIVibFis127983_3305.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AFIS312309:GIWP-3455-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700601 / ES114.

    Entry informationi

    Entry nameiGCSP_VIBF1
    AccessioniPrimary (citable) accession number: Q5DZM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3