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Q5DZM3

- GCSP_VIBF1

UniProt

Q5DZM3 - GCSP_VIBF1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, VF_A0703
Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAFIS312309:GIWP-3455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VF_A0703
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000000537: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi312309.VF_A0703.

Structurei

3D structure databases

ProteinModelPortaliQ5DZM3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5DZM3-1 [UniParc]FASTAAdd to Basket

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MSQLLQQLGT DNEFIRRHNG PASSEHQHML NTIGAETLQQ LIEETVPSSI    50
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR 100
NVLENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL EIANASLLDE 150
ATAAAEAMTL CKRGGKSKSN LFFVADDVHP QTLAVIKTRA KFIGFDVVVD 200
HESNLDSHDV FGALLQYPGT TGEVKDLTDL IAQAHTKKTL VIVATDLLAS 250
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 300
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH 350
GPEGLKTIAR RVHHFTAIVA KALQTAGFEL EHQHFFDTLT VKTEQQTDIL 400
YTKALASSIN LRKFDTKLGI SFDETTTVSD LVTLLAVFGI DNAECETLSA 450
EVGKDEFAAI PKHCQRTSSF LTHPVFNTYH SETQMLRYLK KLENKDFSLT 500
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK 550
SMLCEITGYD EFSLQPNSGA SGEYAGLIAI QRYHESRGDA HRNVCLIPSS 600
AHGTNPATAS MVSMKVVVVK CDENGNIDMI DLAEKIEKHQ ENLSSIMITY 650
PSTHGVYEEQ VREVCDMVHA AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH 700
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHTENGVQ GMDYAVSAAD 750
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMERL RPHYPVLYRG 800
TNGRIAHECI IDIRPLKETT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM 850
VEPTESEDLA ELDRFCDAMI AIREEMNKVE QGEWPLDNNP LVNAPHTQVD 900
LMSDSWEHPY TREVACFPSS QSKDSKYWPT VNRVDNVYGD RNLICSCPSI 950
ENYEE 955
Length:955
Mass (Da):104,827
Last modified:March 15, 2005 - v1
Checksum:iE15ED1B6CDEA05BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000021 Genomic DNA. Translation: AAW87773.1.
RefSeqiWP_011263534.1. NC_006841.2.
YP_206661.1. NC_006841.2.

Genome annotation databases

EnsemblBacteriaiAAW87773; AAW87773; VF_A0703.
GeneIDi3280782.
KEGGivfi:VF_A0703.
PATRICi20117401. VBIVibFis127983_3305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000021 Genomic DNA. Translation: AAW87773.1 .
RefSeqi WP_011263534.1. NC_006841.2.
YP_206661.1. NC_006841.2.

3D structure databases

ProteinModelPortali Q5DZM3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312309.VF_A0703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW87773 ; AAW87773 ; VF_A0703 .
GeneIDi 3280782.
KEGGi vfi:VF_A0703.
PATRICi 20117401. VBIVibFis127983_3305.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AFIS312309:GIWP-3455-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700601 / ES114.

Entry informationi

Entry nameiGCSP_VIBF1
AccessioniPrimary (citable) accession number: Q5DZM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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