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Protein

Immunoglobulin superfamily member 11

Gene

IGSF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Alternative name(s):
Brain and testis-specific immunoglobulin superfamily protein
Short name:
Bt-IGSF
V-set and immunoglobulin domain-containing protein 3
Gene namesi
Name:IGSF11
Synonyms:BTIGSF, CXADRL1, VSIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16669. IGSF11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 241219ExtracellularSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Topological domaini263 – 431169CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939253.

Polymorphism and mutation databases

BioMutaiIGSF11.
DMDMi311033430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 431409Immunoglobulin superfamily member 11PRO_0000317370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ5DX21.
PaxDbiQ5DX21.
PRIDEiQ5DX21.
TopDownProteomicsiQ5DX21-1. [Q5DX21-1]

PTM databases

PhosphoSiteiQ5DX21.

Expressioni

Tissue specificityi

Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ5DX21.
CleanExiHS_IGSF11.
ExpressionAtlasiQ5DX21. baseline and differential.
GenevisibleiQ5DX21. HS.

Organism-specific databases

HPAiHPA046377.

Interactioni

Protein-protein interaction databases

BioGridi127445. 1 interaction.
STRINGi9606.ENSP00000377370.

Structurei

3D structure databases

ProteinModelPortaliQ5DX21.
SMRiQ5DX21. Positions 32-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 136114Ig-like V-typeAdd
BLAST
Domaini144 – 23491Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5DX21.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ5DX21.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DX21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQPA VLPCTFTTSA
60 70 80 90 100
ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ
160 170 180 190 200
IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAGAIGTG
260 270 280 290 300
AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG
360 370 380 390 400
NANIPSIYAN GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH
410 420 430
THSYTISHAT LERIGAVPVM VPAQSRAGSL V
Length:431
Mass (Da):46,120
Last modified:November 2, 2010 - v3
Checksum:i724985A1F8DEA8FC
GO
Isoform 2 (identifier: Q5DX21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT

Show »
Length:430
Mass (Da):46,241
Checksum:i3B6A2BA2005943B0
GO
Isoform 3 (identifier: Q5DX21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT
     211-235: GLYQCVASNAIGTSTCLLDLQVISP → A

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):43,763
Checksum:iC3CF882B958AFCF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671Y → H in BAC05139 (PubMed:14702039).Curated
Sequence conflicti374 – 3741V → A in BAC05139 (PubMed:14702039).Curated
Sequence conflicti395 – 3951K → E in BAD90695 (PubMed:16108831).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391P → T.2 Publications
Corresponds to variant rs2903250 [ dbSNP | Ensembl ].
VAR_038516
Natural varianti333 – 3331E → D.2 Publications
Corresponds to variant rs36052974 [ dbSNP | Ensembl ].
VAR_038517
Natural varianti388 – 3881S → N.
Corresponds to variant rs34908332 [ dbSNP | Ensembl ].
VAR_056048

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MTSQR…LLSLH → MSLVELLLWWNCFSRT in isoform 2 and isoform 3. 2 PublicationsVSP_030936Add
BLAST
Alternative sequencei211 – 23525GLYQC…QVISP → A in isoform 3. 1 PublicationVSP_030937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071618 mRNA. Translation: BAD90695.1.
AK097667 mRNA. Translation: BAC05139.1.
AC007023 Genomic DNA. No translation available.
AC012032 Genomic DNA. No translation available.
AC068984 Genomic DNA. No translation available.
AC083800 Genomic DNA. No translation available.
BC034411 mRNA. Translation: AAH34411.1.
AL834256 mRNA. Translation: CAD38931.1.
CCDSiCCDS2983.1. [Q5DX21-2]
CCDS46891.1. [Q5DX21-1]
RefSeqiNP_001015887.1. NM_001015887.1. [Q5DX21-1]
NP_689751.2. NM_152538.2. [Q5DX21-2]
XP_011510771.1. XM_011512469.1. [Q5DX21-2]
XP_011510772.1. XM_011512470.1. [Q5DX21-2]
XP_011510774.1. XM_011512472.1. [Q5DX21-3]
UniGeneiHs.112873.

Genome annotation databases

EnsembliENST00000354673; ENSP00000346700; ENSG00000144847. [Q5DX21-2]
ENST00000393775; ENSP00000377370; ENSG00000144847. [Q5DX21-1]
ENST00000425327; ENSP00000406092; ENSG00000144847. [Q5DX21-2]
ENST00000441144; ENSP00000401240; ENSG00000144847. [Q5DX21-3]
GeneIDi152404.
KEGGihsa:152404.
UCSCiuc003ebw.5. human. [Q5DX21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071618 mRNA. Translation: BAD90695.1.
AK097667 mRNA. Translation: BAC05139.1.
AC007023 Genomic DNA. No translation available.
AC012032 Genomic DNA. No translation available.
AC068984 Genomic DNA. No translation available.
AC083800 Genomic DNA. No translation available.
BC034411 mRNA. Translation: AAH34411.1.
AL834256 mRNA. Translation: CAD38931.1.
CCDSiCCDS2983.1. [Q5DX21-2]
CCDS46891.1. [Q5DX21-1]
RefSeqiNP_001015887.1. NM_001015887.1. [Q5DX21-1]
NP_689751.2. NM_152538.2. [Q5DX21-2]
XP_011510771.1. XM_011512469.1. [Q5DX21-2]
XP_011510772.1. XM_011512470.1. [Q5DX21-2]
XP_011510774.1. XM_011512472.1. [Q5DX21-3]
UniGeneiHs.112873.

3D structure databases

ProteinModelPortaliQ5DX21.
SMRiQ5DX21. Positions 32-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127445. 1 interaction.
STRINGi9606.ENSP00000377370.

PTM databases

PhosphoSiteiQ5DX21.

Polymorphism and mutation databases

BioMutaiIGSF11.
DMDMi311033430.

Proteomic databases

EPDiQ5DX21.
PaxDbiQ5DX21.
PRIDEiQ5DX21.
TopDownProteomicsiQ5DX21-1. [Q5DX21-1]

Protocols and materials databases

DNASUi152404.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354673; ENSP00000346700; ENSG00000144847. [Q5DX21-2]
ENST00000393775; ENSP00000377370; ENSG00000144847. [Q5DX21-1]
ENST00000425327; ENSP00000406092; ENSG00000144847. [Q5DX21-2]
ENST00000441144; ENSP00000401240; ENSG00000144847. [Q5DX21-3]
GeneIDi152404.
KEGGihsa:152404.
UCSCiuc003ebw.5. human. [Q5DX21-1]

Organism-specific databases

CTDi152404.
GeneCardsiIGSF11.
HGNCiHGNC:16669. IGSF11.
HPAiHPA046377.
MIMi608351. gene.
neXtProtiNX_Q5DX21.
PharmGKBiPA134939253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5DX21.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ5DX21.
TreeFamiTF330875.

Miscellaneous databases

ChiTaRSiIGSF11. human.
GenomeRNAii152404.
NextBioi86952.
PROiQ5DX21.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DX21.
CleanExiHS_IGSF11.
ExpressionAtlasiQ5DX21. baseline and differential.
GenevisibleiQ5DX21. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas."
    Watanabe T., Suda T., Tsunoda T., Uchida N., Ura K., Kato T., Hasegawa S., Satoh S., Ohgi S., Tahara H., Furukawa Y., Nakamura Y.
    Cancer Sci. 96:498-506(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT ASP-333.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS THR-39 AND ASP-333.
    Tissue: Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-39.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-431 (ISOFORM 1).
    Tissue: Uterus.
  6. "IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM."
    Katoh M., Katoh M.
    Int. J. Oncol. 23:525-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, ALTERNATIVE SPLICING.
  7. "BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule."
    Harada H., Suzu S., Hayashi Y., Okada S.
    J. Cell. Physiol. 204:919-926(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIGS11_HUMAN
AccessioniPrimary (citable) accession number: Q5DX21
Secondary accession number(s): C9JZN0
, Q8N4F1, Q8N7T8, Q8NDD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 2, 2010
Last modified: May 11, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.