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Protein

Immunoglobulin superfamily member 11

Gene

IGSF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Alternative name(s):
Brain and testis-specific immunoglobulin superfamily protein
Short name:
Bt-IGSF
V-set and immunoglobulin domain-containing protein 3
Gene namesi
Name:IGSF11
Synonyms:BTIGSF, CXADRL1, VSIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16669. IGSF11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 241ExtracellularSequence analysisAdd BLAST219
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 431CytoplasmicSequence analysisAdd BLAST169

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152404.
OpenTargetsiENSG00000144847.
PharmGKBiPA134939253.

Polymorphism and mutation databases

BioMutaiIGSF11.
DMDMi311033430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031737023 – 431Immunoglobulin superfamily member 11Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation
Modified residuei378Omega-N-methylarginineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiQ5DX21.
PeptideAtlasiQ5DX21.
PRIDEiQ5DX21.
TopDownProteomicsiQ5DX21-1. [Q5DX21-1]

PTM databases

iPTMnetiQ5DX21.
PhosphoSitePlusiQ5DX21.

Expressioni

Tissue specificityi

Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000144847.
CleanExiHS_IGSF11.
ExpressionAtlasiQ5DX21. baseline and differential.
GenevisibleiQ5DX21. HS.

Organism-specific databases

HPAiHPA046377.

Interactioni

Protein-protein interaction databases

BioGridi127445. 1 interactor.
IntActiQ5DX21. 1 interactor.
STRINGi9606.ENSP00000377370.

Structurei

3D structure databases

ProteinModelPortaliQ5DX21.
SMRiQ5DX21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 136Ig-like V-typeAdd BLAST114
Domaini144 – 234Ig-like C2-typeAdd BLAST91

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5DX21.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiQ5DX21.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DX21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQPA VLPCTFTTSA
60 70 80 90 100
ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ
160 170 180 190 200
IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAGAIGTG
260 270 280 290 300
AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG
360 370 380 390 400
NANIPSIYAN GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH
410 420 430
THSYTISHAT LERIGAVPVM VPAQSRAGSL V
Length:431
Mass (Da):46,120
Last modified:November 2, 2010 - v3
Checksum:i724985A1F8DEA8FC
GO
Isoform 2 (identifier: Q5DX21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT

Show »
Length:430
Mass (Da):46,241
Checksum:i3B6A2BA2005943B0
GO
Isoform 3 (identifier: Q5DX21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT
     211-235: GLYQCVASNAIGTSTCLLDLQVISP → A

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):43,763
Checksum:iC3CF882B958AFCF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267Y → H in BAC05139 (PubMed:14702039).Curated1
Sequence conflicti374V → A in BAC05139 (PubMed:14702039).Curated1
Sequence conflicti395K → E in BAD90695 (PubMed:16108831).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03851639P → T.2 PublicationsCorresponds to variant rs2903250dbSNPEnsembl.1
Natural variantiVAR_038517333E → D.2 PublicationsCorresponds to variant rs36052974dbSNPEnsembl.1
Natural variantiVAR_056048388S → N.Corresponds to variant rs34908332dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309361 – 17MTSQR…LLSLH → MSLVELLLWWNCFSRT in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_030937211 – 235GLYQC…QVISP → A in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071618 mRNA. Translation: BAD90695.1.
AK097667 mRNA. Translation: BAC05139.1.
AC007023 Genomic DNA. No translation available.
AC012032 Genomic DNA. No translation available.
AC068984 Genomic DNA. No translation available.
AC083800 Genomic DNA. No translation available.
BC034411 mRNA. Translation: AAH34411.1.
AL834256 mRNA. Translation: CAD38931.1.
CCDSiCCDS2983.1. [Q5DX21-2]
CCDS46891.1. [Q5DX21-1]
RefSeqiNP_001015887.1. NM_001015887.1. [Q5DX21-1]
NP_689751.2. NM_152538.2. [Q5DX21-2]
XP_011510771.1. XM_011512469.1. [Q5DX21-2]
XP_011510772.1. XM_011512470.1. [Q5DX21-2]
XP_011510774.1. XM_011512472.1. [Q5DX21-3]
UniGeneiHs.112873.

Genome annotation databases

EnsembliENST00000354673; ENSP00000346700; ENSG00000144847. [Q5DX21-2]
ENST00000393775; ENSP00000377370; ENSG00000144847. [Q5DX21-1]
ENST00000425327; ENSP00000406092; ENSG00000144847. [Q5DX21-2]
ENST00000441144; ENSP00000401240; ENSG00000144847. [Q5DX21-3]
GeneIDi152404.
KEGGihsa:152404.
UCSCiuc003ebw.5. human. [Q5DX21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071618 mRNA. Translation: BAD90695.1.
AK097667 mRNA. Translation: BAC05139.1.
AC007023 Genomic DNA. No translation available.
AC012032 Genomic DNA. No translation available.
AC068984 Genomic DNA. No translation available.
AC083800 Genomic DNA. No translation available.
BC034411 mRNA. Translation: AAH34411.1.
AL834256 mRNA. Translation: CAD38931.1.
CCDSiCCDS2983.1. [Q5DX21-2]
CCDS46891.1. [Q5DX21-1]
RefSeqiNP_001015887.1. NM_001015887.1. [Q5DX21-1]
NP_689751.2. NM_152538.2. [Q5DX21-2]
XP_011510771.1. XM_011512469.1. [Q5DX21-2]
XP_011510772.1. XM_011512470.1. [Q5DX21-2]
XP_011510774.1. XM_011512472.1. [Q5DX21-3]
UniGeneiHs.112873.

3D structure databases

ProteinModelPortaliQ5DX21.
SMRiQ5DX21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127445. 1 interactor.
IntActiQ5DX21. 1 interactor.
STRINGi9606.ENSP00000377370.

PTM databases

iPTMnetiQ5DX21.
PhosphoSitePlusiQ5DX21.

Polymorphism and mutation databases

BioMutaiIGSF11.
DMDMi311033430.

Proteomic databases

PaxDbiQ5DX21.
PeptideAtlasiQ5DX21.
PRIDEiQ5DX21.
TopDownProteomicsiQ5DX21-1. [Q5DX21-1]

Protocols and materials databases

DNASUi152404.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354673; ENSP00000346700; ENSG00000144847. [Q5DX21-2]
ENST00000393775; ENSP00000377370; ENSG00000144847. [Q5DX21-1]
ENST00000425327; ENSP00000406092; ENSG00000144847. [Q5DX21-2]
ENST00000441144; ENSP00000401240; ENSG00000144847. [Q5DX21-3]
GeneIDi152404.
KEGGihsa:152404.
UCSCiuc003ebw.5. human. [Q5DX21-1]

Organism-specific databases

CTDi152404.
DisGeNETi152404.
GeneCardsiIGSF11.
HGNCiHGNC:16669. IGSF11.
HPAiHPA046377.
MIMi608351. gene.
neXtProtiNX_Q5DX21.
OpenTargetsiENSG00000144847.
PharmGKBiPA134939253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5DX21.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiQ5DX21.
TreeFamiTF330875.

Miscellaneous databases

ChiTaRSiIGSF11. human.
GenomeRNAii152404.
PROiQ5DX21.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144847.
CleanExiHS_IGSF11.
ExpressionAtlasiQ5DX21. baseline and differential.
GenevisibleiQ5DX21. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGS11_HUMAN
AccessioniPrimary (citable) accession number: Q5DX21
Secondary accession number(s): C9JZN0
, Q8N4F1, Q8N7T8, Q8NDD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.