Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-7

Gene

Cdh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-7
Gene namesi
Name:Cdh7
Synonyms:Cad7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306856. Cdh7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 607580ExtracellularSequence analysisAdd
BLAST
Transmembranei608 – 62821HelicalSequence analysisAdd
BLAST
Topological domaini629 – 785157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 4720Sequence analysisPRO_0000320092Add
BLAST
Chaini48 – 785738Cadherin-7PRO_0000320093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis
Modified residuei785 – 7851PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5DWV2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049491.

Structurei

3D structure databases

ProteinModelPortaliQ5DWV2.
SMRiQ5DWV2. Positions 48-369, 715-776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 153105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 262109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 377115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 482105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini482 – 599118Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ5DWV2.
KOiK06799.
PhylomeDBiQ5DWV2.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5DWV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKVELCR FLQLIALFLC FSGMNQAELP RSRSKPYFQL GRSRTKRSWV
60 70 80 90 100
WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG FIKYILSGEG ASSIFIIDEN
110 120 130 140 150
TGDIHATKRL DREEQAYYTL RAQALDRLTN KPVEPESEFV IKIQDINDNE
160 170 180 190 200
PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP
210 220 230 240 250
YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV
260 270 280 290 300
TLTDVNDNPP RFPRRSYQYN GPESLPVASV VARIKAADAD IGVNAEMEYK
310 320 330 340 350
IVDGDGLGIF KISPDKDTQE GIITIQKELD FEAKTSYTLR IEAANRDADP
360 370 380 390 400
RFLSLGPFSD TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGHIIGTVA
410 420 430 440 450
AHDPDSSNSP VRYSIDRNTD LERYFNIDAN SGIITTAKSL DRETNPVHNI
460 470 480 490 500
TVLAMESQNP SQVGRGYVAI TILDINDNAP EFAMDYETTV CENAQPGQVI
510 520 530 540 550
QKISAIDKDE PSNGHQFYFS LTTDMANNLN SSLKDNKDNT ASILTRRNGF
560 570 580 590 600
RRQEQSVYYL PIFIVDNGSP SLSSTNTLTI RVCDCDADGI AQTCNAEAYI
610 620 630 640 650
LPAGLSTGAL IAILACVLTL LVLILLIVTM KRRKKEPLIF DEERDIRENI
660 670 680 690 700
VRYDDEGGGE EDTEAFDMAA LRNLNVVRDT KTRRDVTPEI QFLSRPTFKN
710 720 730 740 750
IPDNVIFREF IWERLKEADV DPGAPPYDSL QTYAFEGNGS VAESLGSLDS
760 770 780
NSSNSDQNYD YLSDWGPRFK RLAEMYGNGQ ESLYS
Length:785
Mass (Da):87,270
Last modified:March 29, 2005 - v1
Checksum:iAAA4A157449FD55F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121031 mRNA. Translation: BAD90595.1.
RefSeqiNP_001012755.1. NM_001012737.1.
UniGeneiRn.198947.

Genome annotation databases

GeneIDi29162.
KEGGirno:29162.
UCSCiRGD:1306856. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121031 mRNA. Translation: BAD90595.1.
RefSeqiNP_001012755.1. NM_001012737.1.
UniGeneiRn.198947.

3D structure databases

ProteinModelPortaliQ5DWV2.
SMRiQ5DWV2. Positions 48-369, 715-776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049491.

Proteomic databases

PaxDbiQ5DWV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29162.
KEGGirno:29162.
UCSCiRGD:1306856. rat.

Organism-specific databases

CTDi1005.
RGDi1306856. Cdh7.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ5DWV2.
KOiK06799.
PhylomeDBiQ5DWV2.

Miscellaneous databases

NextBioi608201.
PROiQ5DWV2.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expressions of rat cadherin-7 and 20 in the developing nervous system."
    Takahashi M., Osumi N.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCADH7_RAT
AccessioniPrimary (citable) accession number: Q5DWV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 29, 2005
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.