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Protein

Cadherin-20

Gene

Cdh20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-20
Gene namesi
Name:Cdh20
Synonyms:Cad20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305438. Cdh20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini60 – 619560ExtracellularSequence analysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence analysisAdd
BLAST
Topological domaini641 – 801161CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Propeptidei35 – 5925Sequence analysisPRO_0000320098Add
BLAST
Chaini60 – 801742Cadherin-20PRO_0000320099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence analysis
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ5DWV1.
PRIDEiQ5DWV1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019907.

Structurei

3D structure databases

ProteinModelPortaliQ5DWV1.
SMRiQ5DWV1. Positions 60-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 165105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 274109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 389115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 494105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 610117Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ5DWV1.
KOiK06807.
PhylomeDBiQ5DWV1.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5DWV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTTGRMSNA KSWLGLGTSL YFWALMDLAT TVLSSTPMPE VELDTLFSGK
60 70 80 90 100
PQSHQRSRRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG
110 120 130 140 150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE
160 170 180 190 200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS
210 220 230 240 250
ARVVYSILQG QPYFSVDSKT GIIRTALMNM DREAKEYYEV IIQAKDMGGQ
260 270 280 290 300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPVS STVGRVFAKD
310 320 330 340 350
LDEGINAEMK YTIVDGDGAD AFDINTDPNF QVGIITVKKP LSFESKKSYT
360 370 380 390 400
LKVEGSNPHV EMRFLNLGPF QDTTTVHIIV EDVDEPPVFE PRFYFVEVPE
410 420 430 440 450
DVTIGTTIQI ISAKDPDMTN NSIRYSIDRG SDPGRFFYVD ITTGALMTAR
460 470 480 490 500
PLDREEFSWH NITVLAMEMN NPSQVGSVAA TIKVLDVNDN APEFPRFYEA
510 520 530 540 550
FICENAKAGQ LIQTVSAVDQ DDPHNGQHFY YSLAPEAANN PNFTVRDNQD
560 570 580 590 600
NTARILTRRS GFRQQEQSVF YLPILIADSG QPVLSSTGTL TIQVCSCSDD
610 620 630 640 650
GHVMSCSPEA YMLPVSLSRG ALIAILACVF VLLVLVLLIL SMRRHRKQPY
660 670 680 690 700
IIDDDENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD
710 720 730 740 750
MLPEIESLSR YVPQTCAVSS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF
760 770 780 790 800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPSPL

W
Length:801
Mass (Da):89,057
Last modified:March 29, 2005 - v1
Checksum:i75622A6AC3F22062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121033 mRNA. Translation: BAD90596.1.
RefSeqiNP_001012766.1. NM_001012748.1.
UniGeneiRn.62576.

Genome annotation databases

GeneIDi363948.
KEGGirno:363948.
UCSCiRGD:1305438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121033 mRNA. Translation: BAD90596.1.
RefSeqiNP_001012766.1. NM_001012748.1.
UniGeneiRn.62576.

3D structure databases

ProteinModelPortaliQ5DWV1.
SMRiQ5DWV1. Positions 60-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019907.

Proteomic databases

PaxDbiQ5DWV1.
PRIDEiQ5DWV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi363948.
KEGGirno:363948.
UCSCiRGD:1305438. rat.

Organism-specific databases

CTDi28316.
RGDi1305438. Cdh20.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ5DWV1.
KOiK06807.
PhylomeDBiQ5DWV1.

Miscellaneous databases

NextBioi684534.
PROiQ5DWV1.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expressions of rat cadherin-7 and 20 in the developing nervous system."
    Takahashi M., Osumi N.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCAD20_RAT
AccessioniPrimary (citable) accession number: Q5DWV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 29, 2005
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.