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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

nad7

Organism
Nyctotherus ovalis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Component of the iron-sulfur (IP) fragment of the enzyme.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:nad7
Encoded oniHydrogenosome
OrganismiNyctotherus ovalis
Taxonomic identifieri70075 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataArmophoreaArmophoridaMetopidaeNyctotherus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Hydrogenosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412NADH-ubiquinone oxidoreductase 49 kDa subunitPRO_0000118595Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5DUX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5DUX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRSSSLQKN IMLLRVGSKD STRFRILILN FGPQHPASHG VLRLVIVIIG
60 70 80 90 100
EVVTKLDPHI GFLHRGTERL VEEHSYMNAA VFMDRLDYTT VLTQTHAYCL
110 120 130 140 150
AVEQALAKSR LCIRTQLLRT IFDELSRILN HLLSIATHAL DIGTMAMLFW
160 170 180 190 200
AFEDRERIME LYEYISGARM HTALYYPNQT LDHILTNELL AKILIFSRNS
210 220 230 240 250
EKTYTEIYIA LYNNRVWRLR LCGIGVVSTE ISTSTTISGP VARSTGLQLD
260 270 280 290 300
MRSGENYQYG YYASLTLRIF LGISGDSFDR FIIRLRELFE STRLIYNSLI
310 320 330 340 350
ELSAYINISV YNMCSYSNNP HLKIESLIEL FRYSLGEYLL NISLVSGFVE
360 370 380 390 400
SGKGIFGIML AANNTNRPYR LYIRSPAYMH LQLLPKLGAG HHIADLATLL
410
GSIDVVFGEV DR
Length:412
Mass (Da):46,974
Last modified:March 29, 2005 - v1
Checksum:i2760DF6EB2DB6E89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871267 Genomic DNA. Translation: CAI38863.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871267 Genomic DNA. Translation: CAI38863.1.

3D structure databases

ProteinModelPortaliQ5DUX5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNDUS2_NYCOV
AccessioniPrimary (citable) accession number: Q5DUX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 29, 2005
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.