Reviewed, UniProtKB/Swiss-Prot Q5DUX5 (NDUS2_NYCOV)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7

Gene names

Name:

nad7

Encoded on

Hydrogenosome

Organism

Nyctotherus ovalis

Taxonomic identifier

70075 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Armophorea › Armophorida › Metopidae › Nyctotherus

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subcellular location	Hydrogenosome.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Cellular component	Hydrogenosome
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	hydrogenosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	NADH-ubiquinone oxidoreductase 49 kDa subunit		PRO_0000118595

Sequences

	Sequence		Length	Mass (Da)
	Q5DUX5-1 [UniParc]. Last modified March 29, 2005. Version 1. Checksum: 2760DF6EB2DB6E89	FASTA	412	46,974
	10 20 30 40 50 60 MMRSSSLQKN IMLLRVGSKD STRFRILILN FGPQHPASHG VLRLVIVIIG EVVTKLDPHI 70 80 90 100 110 120 GFLHRGTERL VEEHSYMNAA VFMDRLDYTT VLTQTHAYCL AVEQALAKSR LCIRTQLLRT 130 140 150 160 170 180 IFDELSRILN HLLSIATHAL DIGTMAMLFW AFEDRERIME LYEYISGARM HTALYYPNQT 190 200 210 220 230 240 LDHILTNELL AKILIFSRNS EKTYTEIYIA LYNNRVWRLR LCGIGVVSTE ISTSTTISGP 250 260 270 280 290 300 VARSTGLQLD MRSGENYQYG YYASLTLRIF LGISGDSFDR FIIRLRELFE STRLIYNSLI 310 320 330 340 350 360 ELSAYINISV YNMCSYSNNP HLKIESLIEL FRYSLGEYLL NISLVSGFVE SGKGIFGIML 370 380 390 400 410 AANNTNRPYR LYIRSPAYMH LQLLPKLGAG HHIADLATLL GSIDVVFGEV DR

References

[1]

"An anaerobic mitochondrion that produces hydrogen." Boxma B., de Graaf R.M., van der Staay G.W.M., van Alen T.A., Ricard G., Gabaldon T., van Hoek A.H.A.M., Moon-van der Staay S.Y., Koopman W.J.H., van Hellemond J.J., Tielens A.G.M., Friedrich T., Veenhuis M., Huynen M.A., Hackstein J.H.P. Nature 434:74-79(2005) [PubMed: 15744302] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ871267 Genomic DNA. Translation: CAI38863.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.6.5.3. 289509. 1.6.99.3. 289509.
Family and domain databases
InterPro	IPR001135. NADH_Q_OxRdtase_suD. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
PROSITE	PS00535. COMPLEX1_49K. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_NYCOV

Accession

Primary (citable) accession number: Q5DUX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	March 29, 2005
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)