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Protein

Protein NLRC3

Gene

Nlrc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1518ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • negative regulation of interleukin-12 production Source: CACAO
  • negative regulation of interleukin-1 beta production Source: CACAO
  • negative regulation of interleukin-6 production Source: CACAO
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: CACAO
  • regulation of protein ubiquitination Source: MGI
  • response to lipopolysaccharide Source: MGI
  • T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NLRC3
Gene namesi
Name:Nlrc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2444070. Nlrc3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Protein NLRC3PRO_0000296188Add
BLAST

Proteomic databases

EPDiQ5DU56.
MaxQBiQ5DU56.
PaxDbiQ5DU56.
PRIDEiQ5DU56.

PTM databases

PhosphoSiteiQ5DU56.

Expressioni

Gene expression databases

CleanExiMM_NLRC3.
ExpressionAtlasiQ5DU56. baseline and differential.
GenevisibleiQ5DU56. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137628.

Structurei

3D structure databases

ProteinModelPortaliQ5DU56.
SMRiQ5DU56. Positions 572-1063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 459322NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati338 – 36225LRR 1Add
BLAST
Repeati570 – 59324LRR 2Add
BLAST
Repeati632 – 66231LRR 3Add
BLAST
Repeati664 – 68724LRR 4Add
BLAST
Repeati692 – 71524LRR 5Add
BLAST
Repeati720 – 74324LRR 6Add
BLAST
Repeati748 – 77124LRR 7Add
BLAST
Repeati776 – 79924LRR 8Add
BLAST
Repeati804 – 82724LRR 9Add
BLAST
Repeati832 – 85524LRR 10Add
BLAST
Repeati860 – 88324LRR 11Add
BLAST
Repeati888 – 91124LRR 12Add
BLAST
Repeati916 – 93924LRR 13Add
BLAST
Repeati972 – 99524LRR 14Add
BLAST
Repeati1000 – 102223LRR 15Add
BLAST
Repeati1028 – 105124LRR 16Add
BLAST

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000108875.
HOVERGENiHBG055285.
InParanoidiQ5DU56.
PhylomeDBiQ5DU56.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 10 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRRYSHDPP GSFRETKVFG FRGEYGCKAL VDLLAGKGSQ LLQVRDKMPD
60 70 80 90 100
SPLGSQSNES RIPKHSEALL SRVGNDPELG SPSHRLASLM LVEGLTDLQL
110 120 130 140 150
KEHDFTQVEA TRGVWHPARV ITLDRLFLPL SRVSIPPRVS LTIGVAGVGK
160 170 180 190 200
TTLVRHFVHC WARGQVGKGF SRVLPLTFRD LNTYEKLSAD RLIQSIFSSI
210 220 230 240 250
GEASLVATAP DRVLLVLDGL DECKTPLEFS NTMACSDPKK EIQVDHLITN
260 270 280 290 300
IIRGNLFPEI SVWITSRPSA AGQIPGGLVD RMTEIRGLTE EEIKVCLEQM
310 320 330 340 350
FPEEQNLLGQ VLSQVQANRA LYLMCTVPAF CRLTGLALGH LYRTRLAVQD
360 370 380 390 400
IELPLPQTLC ELYSWYFRMA LGGEGQDKEK VSPRIKQVTQ GARKMVGTLG
410 420 430 440 450
RLAFHGLVKK KYVFYEQDMK AFGVDLALLQ NTLCSCLLQR EETLASSVAY
460 470 480 490 500
CFIHLSLQEF VAATYYYSAS KRAIFDLFTE SGMSWPRLGF LAHFRCAAQR
510 520 530 540 550
ATQAKDGRLD VFLRFLSGLL SPRVNTLLAG SLLSQGEHQS YRDQVAEVLQ
560 570 580 590 600
GFLHPDAAVC ARAINVLYCL SELRHTELAC SVEEAMRSGT LAGMTSPSHR
610 620 630 640 650
TALAYLLQMS DICSPEADFS LCLSQHVLQS LLPQLLYCQS LRLDNNQFQD
660 670 680 690 700
PVMELLGSVL SGKDCRIRKI SLAENQIGNK GAKALARSLL VNRSLITLDL
710 720 730 740 750
RSNSIGPPGA KALADALKIN RTLTSLSLQS NVIKDDGVMC VAEALVSNQT
760 770 780 790 800
ISMLQLQKNL IGLIGAQQMA DALKQNRSLK ALMFSSNTIG DRGAIALAEA
810 820 830 840 850
LKVNQILENL DLQSNSISDM GVTVLMRALC SNQTLSSLNL RENSISPEGA
860 870 880 890 900
QALTQALCRN NTLKHLDLTA NLLHDRGAQA IAVAVGENHS LTHLHLQWNF
910 920 930 940 950
IQAGAARALG QALQLNRTLT TLDLQENAIG DEGASSVAGA LKVNTTLIAL
960 970 980 990 1000
YLQVASIGSQ GAQALGEALT VNRTLEILDL RGNDVGAAGA KALANALKLN
1010 1020 1030 1040 1050
SSLRRLNLQE NSLGMDGAIF VASALSENHG LHHINLQGNP IGESAARMIS
1060
EAIKTNAPTC TVEI
Length:1,064
Mass (Da):115,993
Last modified:July 24, 2007 - v2
Checksum:i00FEB5FEDB6083C0
GO
Isoform 2 (identifier: Q5DU56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MRRRYSHDPPGSFRETKVFGFRGEYGC → MQAEPFSTLE...YSVGSPAEQV
     643-688: LDNNQFQDPV...NKGAKALARS → WVWGPCRERA...HSWVLSHHSN
     689-1064: Missing.

Show »
Length:726
Mass (Da):80,819
Checksum:i49B0790CAEB64D8C
GO
Isoform 3 (identifier: Q5DU56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):41,669
Checksum:i19936424DDBB4348
GO
Isoform 4 (identifier: Q5DU56-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG
     979-979: D → E
     980-1064: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):32,882
Checksum:iA87126643181743D
GO
Isoform 5 (identifier: Q5DU56-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-636: Missing.
     637-641: YCQSL → MAPLP
     841-875: RENSISPEGAQALTQALCRNNTLKHLDLTANLLHD → MSPQPARKLHQPRGSPGPHSSSLQEQHSEALGPDS
     876-1064: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):25,538
Checksum:iF63A1D1FCC71C7B0
GO

Sequence cautioni

The sequence BAD90390.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 667667Missing in isoform 3 and isoform 4. 1 PublicationVSP_027139Add
BLAST
Alternative sequencei1 – 636636Missing in isoform 5. 1 PublicationVSP_027140Add
BLAST
Alternative sequencei1 – 2727MRRRY…GEYGC → MQAEPFSTLEQPPWQEGDNI GSPGSVLALYSQLLAANTDS TRKQEVWTDRETCLAYSVGS PAEQV in isoform 2. 1 PublicationVSP_027141Add
BLAST
Alternative sequencei637 – 6415YCQSL → MAPLP in isoform 5. 1 PublicationVSP_027142
Alternative sequencei643 – 68846LDNNQ…ALARS → WVWGPCRERAKEKEPLEWFL ASSHPFPCSLLRLLEFHSWV LSHHSN in isoform 2. 1 PublicationVSP_027143Add
BLAST
Alternative sequencei668 – 6703RKI → MAG in isoform 3 and isoform 4. 1 PublicationVSP_027144
Alternative sequencei689 – 1064376Missing in isoform 2. 1 PublicationVSP_027145Add
BLAST
Alternative sequencei841 – 87535RENSI…NLLHD → MSPQPARKLHQPRGSPGPHS SSLQEQHSEALGPDS in isoform 5. 1 PublicationVSP_027146Add
BLAST
Alternative sequencei876 – 1064189Missing in isoform 5. 1 PublicationVSP_027147Add
BLAST
Alternative sequencei979 – 9791D → E in isoform 4. 1 PublicationVSP_027148
Alternative sequencei980 – 106485Missing in isoform 4. 1 PublicationVSP_027149Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220314 mRNA. Translation: BAD90390.1. Different initiation.
AK079766 mRNA. Translation: BAC37747.1.
AK084199 mRNA. Translation: BAC39136.1.
AK171971 mRNA. Translation: BAE42752.1.
BC130223 mRNA. Translation: AAI30224.1.
CCDSiCCDS70677.1. [Q5DU56-3]
RefSeqiNP_780756.1. NM_175547.3. [Q5DU56-3]
UniGeneiMm.215994.

Genome annotation databases

EnsembliENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871. [Q5DU56-3]
GeneIDi268857.
KEGGimmu:268857.
UCSCiuc007xzd.1. mouse. [Q5DU56-3]
uc007xze.1. mouse. [Q5DU56-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220314 mRNA. Translation: BAD90390.1. Different initiation.
AK079766 mRNA. Translation: BAC37747.1.
AK084199 mRNA. Translation: BAC39136.1.
AK171971 mRNA. Translation: BAE42752.1.
BC130223 mRNA. Translation: AAI30224.1.
CCDSiCCDS70677.1. [Q5DU56-3]
RefSeqiNP_780756.1. NM_175547.3. [Q5DU56-3]
UniGeneiMm.215994.

3D structure databases

ProteinModelPortaliQ5DU56.
SMRiQ5DU56. Positions 572-1063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137628.

PTM databases

PhosphoSiteiQ5DU56.

Proteomic databases

EPDiQ5DU56.
MaxQBiQ5DU56.
PaxDbiQ5DU56.
PRIDEiQ5DU56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871. [Q5DU56-3]
GeneIDi268857.
KEGGimmu:268857.
UCSCiuc007xzd.1. mouse. [Q5DU56-3]
uc007xze.1. mouse. [Q5DU56-4]

Organism-specific databases

CTDi197358.
MGIiMGI:2444070. Nlrc3.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000108875.
HOVERGENiHBG055285.
InParanoidiQ5DU56.
PhylomeDBiQ5DU56.

Miscellaneous databases

PROiQ5DU56.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NLRC3.
ExpressionAtlasiQ5DU56. baseline and differential.
GenevisibleiQ5DU56. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 10 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Strain: C57BL/6J and NOD.
    Tissue: Embryonic eye, Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).

Entry informationi

Entry nameiNLRC3_MOUSE
AccessioniPrimary (citable) accession number: Q5DU56
Secondary accession number(s): A1L3P6
, Q3TAB7, Q8BJF4, Q8BV65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 11, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.