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Protein

Protein NLRC3

Gene

Nlrc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 151ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • negative regulation of interleukin-12 production Source: CACAO
  • negative regulation of interleukin-1 beta production Source: CACAO
  • negative regulation of interleukin-6 production Source: CACAO
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: CACAO
  • regulation of protein ubiquitination Source: MGI
  • response to lipopolysaccharide Source: MGI
  • T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NLRC3
Gene namesi
Name:Nlrc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2444070. Nlrc3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002961881 – 1064Protein NLRC3Add BLAST1064

Proteomic databases

EPDiQ5DU56.
PaxDbiQ5DU56.
PRIDEiQ5DU56.

PTM databases

PhosphoSitePlusiQ5DU56.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049871.
CleanExiMM_NLRC3.
ExpressionAtlasiQ5DU56. baseline and differential.
GenevisibleiQ5DU56. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137628.

Structurei

3D structure databases

ProteinModelPortaliQ5DU56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 459NACHTPROSITE-ProRule annotationAdd BLAST322
Repeati338 – 362LRR 1Add BLAST25
Repeati570 – 593LRR 2Add BLAST24
Repeati632 – 662LRR 3Add BLAST31
Repeati664 – 687LRR 4Add BLAST24
Repeati692 – 715LRR 5Add BLAST24
Repeati720 – 743LRR 6Add BLAST24
Repeati748 – 771LRR 7Add BLAST24
Repeati776 – 799LRR 8Add BLAST24
Repeati804 – 827LRR 9Add BLAST24
Repeati832 – 855LRR 10Add BLAST24
Repeati860 – 883LRR 11Add BLAST24
Repeati888 – 911LRR 12Add BLAST24
Repeati916 – 939LRR 13Add BLAST24
Repeati972 – 995LRR 14Add BLAST24
Repeati1000 – 1022LRR 15Add BLAST23
Repeati1028 – 1051LRR 16Add BLAST24

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133673.
HOGENOMiHOG000108875.
HOVERGENiHBG055285.
InParanoidiQ5DU56.
PhylomeDBiQ5DU56.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 10 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRRYSHDPP GSFRETKVFG FRGEYGCKAL VDLLAGKGSQ LLQVRDKMPD
60 70 80 90 100
SPLGSQSNES RIPKHSEALL SRVGNDPELG SPSHRLASLM LVEGLTDLQL
110 120 130 140 150
KEHDFTQVEA TRGVWHPARV ITLDRLFLPL SRVSIPPRVS LTIGVAGVGK
160 170 180 190 200
TTLVRHFVHC WARGQVGKGF SRVLPLTFRD LNTYEKLSAD RLIQSIFSSI
210 220 230 240 250
GEASLVATAP DRVLLVLDGL DECKTPLEFS NTMACSDPKK EIQVDHLITN
260 270 280 290 300
IIRGNLFPEI SVWITSRPSA AGQIPGGLVD RMTEIRGLTE EEIKVCLEQM
310 320 330 340 350
FPEEQNLLGQ VLSQVQANRA LYLMCTVPAF CRLTGLALGH LYRTRLAVQD
360 370 380 390 400
IELPLPQTLC ELYSWYFRMA LGGEGQDKEK VSPRIKQVTQ GARKMVGTLG
410 420 430 440 450
RLAFHGLVKK KYVFYEQDMK AFGVDLALLQ NTLCSCLLQR EETLASSVAY
460 470 480 490 500
CFIHLSLQEF VAATYYYSAS KRAIFDLFTE SGMSWPRLGF LAHFRCAAQR
510 520 530 540 550
ATQAKDGRLD VFLRFLSGLL SPRVNTLLAG SLLSQGEHQS YRDQVAEVLQ
560 570 580 590 600
GFLHPDAAVC ARAINVLYCL SELRHTELAC SVEEAMRSGT LAGMTSPSHR
610 620 630 640 650
TALAYLLQMS DICSPEADFS LCLSQHVLQS LLPQLLYCQS LRLDNNQFQD
660 670 680 690 700
PVMELLGSVL SGKDCRIRKI SLAENQIGNK GAKALARSLL VNRSLITLDL
710 720 730 740 750
RSNSIGPPGA KALADALKIN RTLTSLSLQS NVIKDDGVMC VAEALVSNQT
760 770 780 790 800
ISMLQLQKNL IGLIGAQQMA DALKQNRSLK ALMFSSNTIG DRGAIALAEA
810 820 830 840 850
LKVNQILENL DLQSNSISDM GVTVLMRALC SNQTLSSLNL RENSISPEGA
860 870 880 890 900
QALTQALCRN NTLKHLDLTA NLLHDRGAQA IAVAVGENHS LTHLHLQWNF
910 920 930 940 950
IQAGAARALG QALQLNRTLT TLDLQENAIG DEGASSVAGA LKVNTTLIAL
960 970 980 990 1000
YLQVASIGSQ GAQALGEALT VNRTLEILDL RGNDVGAAGA KALANALKLN
1010 1020 1030 1040 1050
SSLRRLNLQE NSLGMDGAIF VASALSENHG LHHINLQGNP IGESAARMIS
1060
EAIKTNAPTC TVEI
Length:1,064
Mass (Da):115,993
Last modified:July 24, 2007 - v2
Checksum:i00FEB5FEDB6083C0
GO
Isoform 2 (identifier: Q5DU56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MRRRYSHDPPGSFRETKVFGFRGEYGC → MQAEPFSTLE...YSVGSPAEQV
     643-688: LDNNQFQDPV...NKGAKALARS → WVWGPCRERA...HSWVLSHHSN
     689-1064: Missing.

Show »
Length:726
Mass (Da):80,819
Checksum:i49B0790CAEB64D8C
GO
Isoform 3 (identifier: Q5DU56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):41,669
Checksum:i19936424DDBB4348
GO
Isoform 4 (identifier: Q5DU56-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG
     979-979: D → E
     980-1064: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):32,882
Checksum:iA87126643181743D
GO
Isoform 5 (identifier: Q5DU56-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-636: Missing.
     637-641: YCQSL → MAPLP
     841-875: RENSISPEGAQALTQALCRNNTLKHLDLTANLLHD → MSPQPARKLHQPRGSPGPHSSSLQEQHSEALGPDS
     876-1064: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):25,538
Checksum:iF63A1D1FCC71C7B0
GO

Sequence cautioni

The sequence BAD90390 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271391 – 667Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST667
Alternative sequenceiVSP_0271401 – 636Missing in isoform 5. 1 PublicationAdd BLAST636
Alternative sequenceiVSP_0271411 – 27MRRRY…GEYGC → MQAEPFSTLEQPPWQEGDNI GSPGSVLALYSQLLAANTDS TRKQEVWTDRETCLAYSVGS PAEQV in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027142637 – 641YCQSL → MAPLP in isoform 5. 1 Publication5
Alternative sequenceiVSP_027143643 – 688LDNNQ…ALARS → WVWGPCRERAKEKEPLEWFL ASSHPFPCSLLRLLEFHSWV LSHHSN in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_027144668 – 670RKI → MAG in isoform 3 and isoform 4. 1 Publication3
Alternative sequenceiVSP_027145689 – 1064Missing in isoform 2. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_027146841 – 875RENSI…NLLHD → MSPQPARKLHQPRGSPGPHS SSLQEQHSEALGPDS in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_027147876 – 1064Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_027148979D → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_027149980 – 1064Missing in isoform 4. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220314 mRNA. Translation: BAD90390.1. Different initiation.
AK079766 mRNA. Translation: BAC37747.1.
AK084199 mRNA. Translation: BAC39136.1.
AK171971 mRNA. Translation: BAE42752.1.
BC130223 mRNA. Translation: AAI30224.1.
CCDSiCCDS70677.1. [Q5DU56-3]
RefSeqiNP_780756.1. NM_175547.3. [Q5DU56-3]
UniGeneiMm.215994.

Genome annotation databases

EnsembliENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871. [Q5DU56-3]
GeneIDi268857.
KEGGimmu:268857.
UCSCiuc007xzd.1. mouse. [Q5DU56-3]
uc007xze.1. mouse. [Q5DU56-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220314 mRNA. Translation: BAD90390.1. Different initiation.
AK079766 mRNA. Translation: BAC37747.1.
AK084199 mRNA. Translation: BAC39136.1.
AK171971 mRNA. Translation: BAE42752.1.
BC130223 mRNA. Translation: AAI30224.1.
CCDSiCCDS70677.1. [Q5DU56-3]
RefSeqiNP_780756.1. NM_175547.3. [Q5DU56-3]
UniGeneiMm.215994.

3D structure databases

ProteinModelPortaliQ5DU56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137628.

PTM databases

PhosphoSitePlusiQ5DU56.

Proteomic databases

EPDiQ5DU56.
PaxDbiQ5DU56.
PRIDEiQ5DU56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871. [Q5DU56-3]
GeneIDi268857.
KEGGimmu:268857.
UCSCiuc007xzd.1. mouse. [Q5DU56-3]
uc007xze.1. mouse. [Q5DU56-4]

Organism-specific databases

CTDi197358.
MGIiMGI:2444070. Nlrc3.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133673.
HOGENOMiHOG000108875.
HOVERGENiHBG055285.
InParanoidiQ5DU56.
PhylomeDBiQ5DU56.

Miscellaneous databases

PROiQ5DU56.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049871.
CleanExiMM_NLRC3.
ExpressionAtlasiQ5DU56. baseline and differential.
GenevisibleiQ5DU56. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 10 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLRC3_MOUSE
AccessioniPrimary (citable) accession number: Q5DU56
Secondary accession number(s): A1L3P6
, Q3TAB7, Q8BJF4, Q8BV65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.