Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5DU37 (ZFY26_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger FYVE domain-containing protein 26
Gene names
Name:Zfyve26
Synonyms:Kiaa0321
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2529 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair By similarity.

Subunit structure

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Midbody By similarity. Note: Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A By similarity.

Domain

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis By similarity.

Sequence similarities

Belongs to the ZFYVE26 family.

Contains 1 FYVE-type zinc finger.

Sequence caution

The sequence BAD90401.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5DU37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5DU37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1201-2529: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5DU37-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1714: Missing.
     1715-1730: AGKALDLPYPLREKRS → MLVVEQCFVSSLSLSA
     2368-2370: MLG → RRL
     2371-2529: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25292529Zinc finger FYVE domain-containing protein 26
PRO_0000314613

Regions

Zinc finger1802 – 186261FYVE-type
Coiled coil859 – 88426 Potential
Coiled coil1488 – 151528 Potential
Compositional bias745 – 77329Arg-rich
Compositional bias1759 – 17624Poly-Ala

Natural variations

Alternative sequence1 – 17141714Missing in isoform 3.
VSP_030342
Alternative sequence1201 – 25291329Missing in isoform 2.
VSP_030343
Alternative sequence1715 – 173016AGKAL…REKRS → MLVVEQCFVSSLSLSA in isoform 3.
VSP_030344
Alternative sequence2368 – 23703MLG → RRL in isoform 3.
VSP_030345
Alternative sequence2371 – 2529159Missing in isoform 3.
VSP_030346

Experimental info

Sequence conflict4951M → V in BAE21117. Ref.1
Sequence conflict11801Q → H in AAI41360. Ref.3
Sequence conflict24891A → V in AAH06654. Ref.3
Sequence conflict25251S → C in AAH06654. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 1885B6B0421066FD

FASTA2,529282,961
        10         20         30         40         50         60 
MSYPFGKEET ATEEELFEFF CECLRRGDWE LAQACVPQLH RGQGEIPQKV EDILQALVQC 

        70         80         90        100        110        120 
PILLRCGPDI NPQRLAWLWL LVLEKWLAPE KKLLSTAIRR KLEFLFLSED LQGDIPETIL 

       130        140        150        160        170        180 
KELFETLAQG PAGSIPDRRT PQLSPEAVSV LWNLLKQAPR PAQALLELLL EDHHSASLCP 

       190        200        210        220        230        240 
SPLQKSLLDL IREALQTLRD PASQPPGVAD AVCGALQALC CKAELPESEW RVLCEELLET 

       250        260        270        280        290        300 
CRTEDSPLQE ERLLGCLLHK AGRNLLSLYG HTYAEKVAER PPKATLSGKD HPDPERAMLA 

       310        320        330        340        350        360 
LFSTPDPAHA WKMAFFYCLS NNKHFLEQIL VTALTLLKEE DFPSLGYLLD REFRPLSHLL 

       370        380        390        400        410        420 
VLLGWTHCQS LESAKRLLQT LYRTQDQGHD ELLRDACEGL WAHLEVLEWC VQQSSNLIPK 

       430        440        450        460        470        480 
RELLCHLHGG DSHSVLYSLH HLTNLPALNE EEVLKLLQKE PTKDLQGEHE THDASVPEHL 

       490        500        510        520        530        540 
SQCQSLTLYQ GFCAMKYAVY ALCVNSHQHS QCQDCRDSAS EDLALVEPGS DSLPSPGASH 

       550        560        570        580        590        600 
LFPTYLARCR QYLHSIPASL CLEILENIFS LLLITSADLH PEPHLPEDYA EDEDIEGKGP 

       610        620        630        640        650        660 
LGLRSPSESP QHIAATERRS ERASMGPRNP AHTVPGCPKA EPKDSSPGPH KHSFLDLKHF 

       670        680        690        700        710        720 
TSGVNGFLAD EFAMGAFLSL LQEQLTEISS HRTPEETKLP EDQSCSAARD GLQSRLHRFS 

       730        740        750        760        770        780 
KVLSEAQWRY KVVTSNQGSE EQPSRRYRPI ATRHSSLRRG RRTRRTRADG RERGSNPSLE 

       790        800        810        820        830        840 
GTSSELSTST SEGSLSAVSG QVESDSRFQT QPQSSIIPMM FSTPESLLAS CILRGNFAEA 

       850        860        870        880        890        900 
HQVVLMFNLK SSPIAGELMF VERYQEVIQE LARVEHKIEN QNSDGGNNTI RRTGSGRSTL 

       910        920        930        940        950        960 
QAIGSAAAAG MVFYSISDVT EKLLSPSEDP IPTLQEDFWI NATPMETTTP LREVLEDLSP 

       970        980        990       1000       1010       1020 
PAMAAFDLAC CQCQLWKTCK QLLETAERRL SSSLESRGRR LDQVVLNPDG MRGFPFVLQQ 

      1030       1040       1050       1060       1070       1080 
ISKILSYPLM QTGLAKSETL EERGGGAPRS SISELLQMCW PSLTEDCVAS HTSLSQQLEQ 

      1090       1100       1110       1120       1130       1140 
ALQSLREALA LPESKSTPLS CLVEQAAQKA PEAEAHPVHI QSQLLQKTLG RQTPAGHRQT 

      1150       1160       1170       1180       1190       1200 
DYVGAFFSYC SSLAAVLLRS LSSDPDHVEV RVGNPFVLLQ QSSSQLVSHL LLERQVPPDR 

      1210       1220       1230       1240       1250       1260 
LAALLAQEHL NLSVPQVIVS CCCEPLTLCL SRQSQQASSL LTHLGMLARE HASHLLDGLP 

      1270       1280       1290       1300       1310       1320 
LSTLGSPRPS ENPSAERKSH SSPKDSLPAF TASALAFLKS RSKILAMVAC LRTSRGTKVS 

      1330       1340       1350       1360       1370       1380 
KPGLSWKELR GRREAPLTAE KVAQECEHLL EQFPVFEAAL LANWEPLQQA SEPKQSLAAS 

      1390       1400       1410       1420       1430       1440 
LCGQANLSTV LLGLHSSLAL DILTEAFEGA LVARDWPRAL QLIDVYGQDL DDLSIVQDSV 

      1450       1460       1470       1480       1490       1500 
LTCAAVCDKE GWQYLFPVKD ASLRSQLALR FVDKWPLESC LEILAYCVSD MAVQEELKSE 

      1510       1520       1530       1540       1550       1560 
LQRKLMELRV YQKILGLQDP PVWCDWQTLR SCCAEDPSAV MDMMLDSQEY ELCEEWGRLY 

      1570       1580       1590       1600       1610       1620 
PIPREHLVSL HHKHLLHLLE RSEHDKALQL LQRIPDPTMC LEVTERSLDQ HPSLATSHFL 

      1630       1640       1650       1660       1670       1680 
ANYLTSHFYG ELTTDRHREI QALYMGSKVL LTLPEQHRAS YARLSSSPLL MLEQLLMNMK 

      1690       1700       1710       1720       1730       1740 
VDWATTAVQT LHQLLAGQDI GFTLDEVDSL LSRYAGKALD LPYPLREKRS DSMIHLQEPV 

      1750       1760       1770       1780       1790       1800 
HQASDSETLS RSSSAEFSAA AAPGSALVRS PSPKERAFPQ TQPPVEFVPP ETPPARDQWV 

      1810       1820       1830       1840       1850       1860 
PDETESVCMV CCREHFTMFN RRHHCRRCGR LVCGSCSTKK MVVEGFRENP TRVCDQCYSY 

      1870       1880       1890       1900       1910       1920 
YNKDTPEESP CQSEVPDSAK NESPPYSAVV RVPKATEVEW ILSLSEEENE LVRSEFYYEQ 

      1930       1940       1950       1960       1970       1980 
APSASLCIAI LNLHRDSIAC GHQLIEHCCR LSRGLTNPEV DAGLLIDIMK QLLFSAKMMF 

      1990       2000       2010       2020       2030       2040 
VKAGQSQDLA LCDSYISKVD VLHLLVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL 

      2050       2060       2070       2080       2090       2100 
GVEVSTKTGL DSTGAWHAWG MACLKAGNLT VAREKFTRCL KPPLDLNQLS HGSRLVQDVV 

      2110       2120       2130       2140       2150       2160 
EYLESTVRPL VSLQDDDYFA TLRELEATLR TQSLLLEAIP EGKIMNNTYY QECLFYLHNY 

      2170       2180       2190       2200       2210       2220 
STNLAIISFY MRHNCLREAL LHLLNKESPP EVFIEGIFQP SYKSGKLHTL ENLLESIDPT 

      2230       2240       2250       2260       2270       2280 
LESWGAHLIA ACQHLQKNSY YHILYELQQF MKDQVRAAMT CIRFFSHKAK SYTELGEKLS 

      2290       2300       2310       2320       2330       2340 
WLLKAKDHLK IYLQETSRSS GRKKATFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA 

      2350       2360       2370       2380       2390       2400 
GTSQVTTLPL PTLFGNNHMK MEVACKVMLG GKNVEDGFGI AFRVLQDFQL DAAATYCRAA 

      2410       2420       2430       2440       2450       2460 
RQLVEREKYG EIRQLLKCVS ESGMAAKSDG DTILLNCLEA FKRIPPQELE GLIQAIHSDD 

      2470       2480       2490       2500       2510       2520 
NKVRAYLTCC KLRSAYLIAV KQEHSQAAAL VQQVQQAAKS SGDSVVQDIC AQWLLTSHSR 


GAHGSGSRK 

« Hide

Isoform 2 [UniParc].

Checksum: 451848DBC25912DF
Show »

FASTA1,200133,659
Isoform 3 [UniParc].

Checksum: 9C3C4BCD28BD72EE
Show »

FASTA65674,354

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2027-2529 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Head, Testis and Thymus.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryonic intestine.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK029679 mRNA. Translation: BAC26561.1.
AK041668 mRNA. Translation: BAC31027.1.
AK132344 mRNA. Translation: BAE21117.1.
AK169541 mRNA. Translation: BAE41219.1.
AK220333 mRNA. Translation: BAD90401.1. Different initiation.
BC006654 mRNA. Translation: AAH06654.1.
BC141359 mRNA. Translation: AAI41360.1.
CCDSCCDS36481.1. [Q5DU37-1]
RefSeqNP_001008550.1. NM_001008550.1. [Q5DU37-1]
UniGeneMm.297919.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000021547.

PTM databases

PhosphoSiteQ5DU37.

Proteomic databases

PaxDbQ5DU37.
PRIDEQ5DU37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021547; ENSMUSP00000021547; ENSMUSG00000066440. [Q5DU37-1]
GeneID211978.
KEGGmmu:211978.
UCSCuc007oae.1. mouse. [Q5DU37-1]
uc007oaf.1. mouse. [Q5DU37-3]
uc007oah.1. mouse. [Q5DU37-2]

Organism-specific databases

CTD23503.
MGIMGI:1924767. Zfyve26.
RougeSearch...

Phylogenomic databases

eggNOGNOG247110.
GeneTreeENSGT00680000100041.
HOVERGENHBG108766.
InParanoidQ5DU37.
OMACILRGNF.
OrthoDBEOG776SP2.
PhylomeDBQ5DU37.
TreeFamTF324517.

Gene expression databases

BgeeQ5DU37.
CleanExMM_ZFYVE26.
GenevestigatorQ5DU37.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR22835:SF115. PTHR22835:SF115. 1 hit.
PfamPF01363. FYVE. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373419.
PROQ5DU37.
SOURCESearch...

Entry information

Entry nameZFY26_MOUSE
AccessionPrimary (citable) accession number: Q5DU37
Secondary accession number(s): B9EJ71 expand/collapse secondary AC list , Q3TEM9, Q3V1N3, Q8BY74, Q8CDR8, Q923B4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot