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Q5DU37

- ZFY26_MOUSE

UniProt

Q5DU37 - ZFY26_MOUSE

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Protein
Zinc finger FYVE domain-containing protein 26
Gene
Zfyve26, Kiaa0321
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1802 – 186261FYVE-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatidylinositol-3-phosphate binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cytokinesis Source: UniProtKB
  2. double-strand break repair via homologous recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair

Keywords - Ligandi

Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 26
Gene namesi
Name:Zfyve26
Synonyms:Kiaa0321
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1924767. Zfyve26.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Midbody By similarity
Note: Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A By similarity.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. lysosomal membrane Source: Ensembl
  3. midbody Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25292529Zinc finger FYVE domain-containing protein 26
PRO_0000314613Add
BLAST

Proteomic databases

PaxDbiQ5DU37.
PRIDEiQ5DU37.

PTM databases

PhosphoSiteiQ5DU37.

Expressioni

Gene expression databases

BgeeiQ5DU37.
CleanExiMM_ZFYVE26.
GenevestigatoriQ5DU37.

Interactioni

Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021547.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili859 – 88426 Reviewed prediction
Add
BLAST
Coiled coili1488 – 151528 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi745 – 77329Arg-rich
Add
BLAST
Compositional biasi1759 – 17624Poly-Ala

Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis By similarity.

Sequence similaritiesi

Belongs to the ZFYVE26 family.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG247110.
GeneTreeiENSGT00680000100041.
HOVERGENiHBG108766.
InParanoidiQ5DU37.
OMAiCILRGNF.
OrthoDBiEOG776SP2.
PhylomeDBiQ5DU37.
TreeFamiTF324517.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF115. PTHR22835:SF115. 1 hit.
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5DU37-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSYPFGKEET ATEEELFEFF CECLRRGDWE LAQACVPQLH RGQGEIPQKV     50
EDILQALVQC PILLRCGPDI NPQRLAWLWL LVLEKWLAPE KKLLSTAIRR 100
KLEFLFLSED LQGDIPETIL KELFETLAQG PAGSIPDRRT PQLSPEAVSV 150
LWNLLKQAPR PAQALLELLL EDHHSASLCP SPLQKSLLDL IREALQTLRD 200
PASQPPGVAD AVCGALQALC CKAELPESEW RVLCEELLET CRTEDSPLQE 250
ERLLGCLLHK AGRNLLSLYG HTYAEKVAER PPKATLSGKD HPDPERAMLA 300
LFSTPDPAHA WKMAFFYCLS NNKHFLEQIL VTALTLLKEE DFPSLGYLLD 350
REFRPLSHLL VLLGWTHCQS LESAKRLLQT LYRTQDQGHD ELLRDACEGL 400
WAHLEVLEWC VQQSSNLIPK RELLCHLHGG DSHSVLYSLH HLTNLPALNE 450
EEVLKLLQKE PTKDLQGEHE THDASVPEHL SQCQSLTLYQ GFCAMKYAVY 500
ALCVNSHQHS QCQDCRDSAS EDLALVEPGS DSLPSPGASH LFPTYLARCR 550
QYLHSIPASL CLEILENIFS LLLITSADLH PEPHLPEDYA EDEDIEGKGP 600
LGLRSPSESP QHIAATERRS ERASMGPRNP AHTVPGCPKA EPKDSSPGPH 650
KHSFLDLKHF TSGVNGFLAD EFAMGAFLSL LQEQLTEISS HRTPEETKLP 700
EDQSCSAARD GLQSRLHRFS KVLSEAQWRY KVVTSNQGSE EQPSRRYRPI 750
ATRHSSLRRG RRTRRTRADG RERGSNPSLE GTSSELSTST SEGSLSAVSG 800
QVESDSRFQT QPQSSIIPMM FSTPESLLAS CILRGNFAEA HQVVLMFNLK 850
SSPIAGELMF VERYQEVIQE LARVEHKIEN QNSDGGNNTI RRTGSGRSTL 900
QAIGSAAAAG MVFYSISDVT EKLLSPSEDP IPTLQEDFWI NATPMETTTP 950
LREVLEDLSP PAMAAFDLAC CQCQLWKTCK QLLETAERRL SSSLESRGRR 1000
LDQVVLNPDG MRGFPFVLQQ ISKILSYPLM QTGLAKSETL EERGGGAPRS 1050
SISELLQMCW PSLTEDCVAS HTSLSQQLEQ ALQSLREALA LPESKSTPLS 1100
CLVEQAAQKA PEAEAHPVHI QSQLLQKTLG RQTPAGHRQT DYVGAFFSYC 1150
SSLAAVLLRS LSSDPDHVEV RVGNPFVLLQ QSSSQLVSHL LLERQVPPDR 1200
LAALLAQEHL NLSVPQVIVS CCCEPLTLCL SRQSQQASSL LTHLGMLARE 1250
HASHLLDGLP LSTLGSPRPS ENPSAERKSH SSPKDSLPAF TASALAFLKS 1300
RSKILAMVAC LRTSRGTKVS KPGLSWKELR GRREAPLTAE KVAQECEHLL 1350
EQFPVFEAAL LANWEPLQQA SEPKQSLAAS LCGQANLSTV LLGLHSSLAL 1400
DILTEAFEGA LVARDWPRAL QLIDVYGQDL DDLSIVQDSV LTCAAVCDKE 1450
GWQYLFPVKD ASLRSQLALR FVDKWPLESC LEILAYCVSD MAVQEELKSE 1500
LQRKLMELRV YQKILGLQDP PVWCDWQTLR SCCAEDPSAV MDMMLDSQEY 1550
ELCEEWGRLY PIPREHLVSL HHKHLLHLLE RSEHDKALQL LQRIPDPTMC 1600
LEVTERSLDQ HPSLATSHFL ANYLTSHFYG ELTTDRHREI QALYMGSKVL 1650
LTLPEQHRAS YARLSSSPLL MLEQLLMNMK VDWATTAVQT LHQLLAGQDI 1700
GFTLDEVDSL LSRYAGKALD LPYPLREKRS DSMIHLQEPV HQASDSETLS 1750
RSSSAEFSAA AAPGSALVRS PSPKERAFPQ TQPPVEFVPP ETPPARDQWV 1800
PDETESVCMV CCREHFTMFN RRHHCRRCGR LVCGSCSTKK MVVEGFRENP 1850
TRVCDQCYSY YNKDTPEESP CQSEVPDSAK NESPPYSAVV RVPKATEVEW 1900
ILSLSEEENE LVRSEFYYEQ APSASLCIAI LNLHRDSIAC GHQLIEHCCR 1950
LSRGLTNPEV DAGLLIDIMK QLLFSAKMMF VKAGQSQDLA LCDSYISKVD 2000
VLHLLVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL GVEVSTKTGL 2050
DSTGAWHAWG MACLKAGNLT VAREKFTRCL KPPLDLNQLS HGSRLVQDVV 2100
EYLESTVRPL VSLQDDDYFA TLRELEATLR TQSLLLEAIP EGKIMNNTYY 2150
QECLFYLHNY STNLAIISFY MRHNCLREAL LHLLNKESPP EVFIEGIFQP 2200
SYKSGKLHTL ENLLESIDPT LESWGAHLIA ACQHLQKNSY YHILYELQQF 2250
MKDQVRAAMT CIRFFSHKAK SYTELGEKLS WLLKAKDHLK IYLQETSRSS 2300
GRKKATFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA GTSQVTTLPL 2350
PTLFGNNHMK MEVACKVMLG GKNVEDGFGI AFRVLQDFQL DAAATYCRAA 2400
RQLVEREKYG EIRQLLKCVS ESGMAAKSDG DTILLNCLEA FKRIPPQELE 2450
GLIQAIHSDD NKVRAYLTCC KLRSAYLIAV KQEHSQAAAL VQQVQQAAKS 2500
SGDSVVQDIC AQWLLTSHSR GAHGSGSRK 2529
Length:2,529
Mass (Da):282,961
Last modified:January 15, 2008 - v2
Checksum:i1885B6B0421066FD
GO
Isoform 2 (identifier: Q5DU37-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1201-2529: Missing.

Note: No experimental confirmation available.

Show »
Length:1,200
Mass (Da):133,659
Checksum:i451848DBC25912DF
GO
Isoform 3 (identifier: Q5DU37-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1714: Missing.
     1715-1730: AGKALDLPYPLREKRS → MLVVEQCFVSSLSLSA
     2368-2370: MLG → RRL
     2371-2529: Missing.

Note: No experimental confirmation available.

Show »
Length:656
Mass (Da):74,354
Checksum:i9C3C4BCD28BD72EE
GO

Sequence cautioni

The sequence BAD90401.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 17141714Missing in isoform 3.
VSP_030342Add
BLAST
Alternative sequencei1201 – 25291329Missing in isoform 2.
VSP_030343Add
BLAST
Alternative sequencei1715 – 173016AGKAL…REKRS → MLVVEQCFVSSLSLSA in isoform 3.
VSP_030344Add
BLAST
Alternative sequencei2368 – 23703MLG → RRL in isoform 3.
VSP_030345
Alternative sequencei2371 – 2529159Missing in isoform 3.
VSP_030346Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti495 – 4951M → V in BAE21117. 1 Publication
Sequence conflicti1180 – 11801Q → H in AAI41360. 1 Publication
Sequence conflicti2489 – 24891A → V in AAH06654. 1 Publication
Sequence conflicti2525 – 25251S → C in AAH06654. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029679 mRNA. Translation: BAC26561.1.
AK041668 mRNA. Translation: BAC31027.1.
AK132344 mRNA. Translation: BAE21117.1.
AK169541 mRNA. Translation: BAE41219.1.
AK220333 mRNA. Translation: BAD90401.1. Different initiation.
BC006654 mRNA. Translation: AAH06654.1.
BC141359 mRNA. Translation: AAI41360.1.
CCDSiCCDS36481.1. [Q5DU37-1]
RefSeqiNP_001008550.1. NM_001008550.1. [Q5DU37-1]
UniGeneiMm.297919.

Genome annotation databases

EnsembliENSMUST00000021547; ENSMUSP00000021547; ENSMUSG00000066440. [Q5DU37-1]
GeneIDi211978.
KEGGimmu:211978.
UCSCiuc007oae.1. mouse. [Q5DU37-1]
uc007oaf.1. mouse. [Q5DU37-3]
uc007oah.1. mouse. [Q5DU37-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029679 mRNA. Translation: BAC26561.1 .
AK041668 mRNA. Translation: BAC31027.1 .
AK132344 mRNA. Translation: BAE21117.1 .
AK169541 mRNA. Translation: BAE41219.1 .
AK220333 mRNA. Translation: BAD90401.1 . Different initiation.
BC006654 mRNA. Translation: AAH06654.1 .
BC141359 mRNA. Translation: AAI41360.1 .
CCDSi CCDS36481.1. [Q5DU37-1 ]
RefSeqi NP_001008550.1. NM_001008550.1. [Q5DU37-1 ]
UniGenei Mm.297919.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000021547.

PTM databases

PhosphoSitei Q5DU37.

Proteomic databases

PaxDbi Q5DU37.
PRIDEi Q5DU37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021547 ; ENSMUSP00000021547 ; ENSMUSG00000066440 . [Q5DU37-1 ]
GeneIDi 211978.
KEGGi mmu:211978.
UCSCi uc007oae.1. mouse. [Q5DU37-1 ]
uc007oaf.1. mouse. [Q5DU37-3 ]
uc007oah.1. mouse. [Q5DU37-2 ]

Organism-specific databases

CTDi 23503.
MGIi MGI:1924767. Zfyve26.
Rougei Search...

Phylogenomic databases

eggNOGi NOG247110.
GeneTreei ENSGT00680000100041.
HOVERGENi HBG108766.
InParanoidi Q5DU37.
OMAi CILRGNF.
OrthoDBi EOG776SP2.
PhylomeDBi Q5DU37.
TreeFami TF324517.

Miscellaneous databases

NextBioi 373419.
PROi Q5DU37.
SOURCEi Search...

Gene expression databases

Bgeei Q5DU37.
CleanExi MM_ZFYVE26.
Genevestigatori Q5DU37.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR22835:SF115. PTHR22835:SF115. 1 hit.
Pfami PF01363. FYVE. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2027-2529 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head, Testis and Thymus.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiZFY26_MOUSE
AccessioniPrimary (citable) accession number: Q5DU37
Secondary accession number(s): B9EJ71
, Q3TEM9, Q3V1N3, Q8BY74, Q8CDR8, Q923B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi