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Protein

Interactor protein for cytohesin exchange factors 1

Gene

Ipcef1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Gene namesi
Name:Ipcef1
Synonyms:Kiaa0403
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444159. Ipcef1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Interactor protein for cytohesin exchange factors 1PRO_0000326631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q5DU31-2)
Modified residuei164 – 1641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5DU31.
MaxQBiQ5DU31.
PaxDbiQ5DU31.
PRIDEiQ5DU31.

PTM databases

PhosphoSiteiQ5DU31.

Expressioni

Gene expression databases

BgeeiQ5DU31.
ExpressionAtlasiQ5DU31. baseline and differential.
GenevisibleiQ5DU31. MM.

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101242.

Structurei

3D structure databases

ProteinModelPortaliQ5DU31.
SMRiQ5DU31. Positions 17-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 112100PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ5DU31.
OMAiPSEANSC.
OrthoDBiEOG71ZP0W.
TreeFamiTF326495.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRRISCKD LGHADCQGWL YKKKEKGTFL SNKWKKFWVV LKGSSLYWYS
60 70 80 90 100
NQMAEKADGF VNLSDFTVER ASECKKKNAF KINHPQIKAF YFAAENLQEM
110 120 130 140 150
NVWLNKLGFA VTHQESITKD EECYSESEQE DPEVAVEAPP PPYASTTSSP
160 170 180 190 200
VAAQWASSSS PKRRETSCSF SSLENTVKAP SQFSSSGSKE RQSWHNIVNS
210 220 230 240 250
SPATEDAGLP LTFAEQVHTL AFSEASNCQA PENNCITSEG GLLNLLSSDD
260 270 280 290 300
TSSLNNNKDH LTVPDRAAGS RMADREEIKS SEDDEMEKLY KSLEQASLSP
310 320 330 340 350
LGDRRPSTKK ELRKSFVKRC KNPSINEKLH KIRTLNSTLK CKEHDLAMIN
360 370 380 390 400
QLLDDPKLTA RKYREWKVMN TLLIQDIYQQ QAPQDPEVTP QEVMNPTSSD

CVENSL
Length:406
Mass (Da):45,812
Last modified:April 8, 2008 - v2
Checksum:i866733F4E55FFB84
GO
Isoform 2 (identifier: Q5DU31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: V → VVRVD

Show »
Length:410
Mass (Da):46,282
Checksum:iA9A6EFF3E054C0E8
GO
Isoform 3 (identifier: Q5DU31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-298: EEIKSSEDDEMEKLYKSLEQASL → GKPGICLLFLDGEYLLGHCMILI
     299-406: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):33,085
Checksum:i31BD3C4EA711F46A
GO

Sequence cautioni

The sequence BAC29953.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD90405.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE34075.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei151 – 1511V → VVRVD in isoform 2. 1 PublicationVSP_032683
Alternative sequencei276 – 29823EEIKS…EQASL → GKPGICLLFLDGEYLLGHCM ILI in isoform 3. 1 PublicationVSP_032684Add
BLAST
Alternative sequencei299 – 406108Missing in isoform 3. 1 PublicationVSP_032685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157384 mRNA. Translation: BAE34075.1. Different initiation.
AK038257 mRNA. Translation: BAC29953.1. Different initiation.
AK220339 mRNA. Translation: BAD90405.1. Different initiation.
AC155718 Genomic DNA. No translation available.
AC164171 Genomic DNA. No translation available.
CCDSiCCDS56688.1. [Q5DU31-1]
RefSeqiNP_001164271.1. NM_001170800.1. [Q5DU31-1]
UniGeneiMm.331674.

Genome annotation databases

EnsembliENSMUST00000078070; ENSMUSP00000077215; ENSMUSG00000064065. [Q5DU31-2]
ENSMUST00000105617; ENSMUSP00000101242; ENSMUSG00000064065. [Q5DU31-1]
GeneIDi320495.
KEGGimmu:320495.
UCSCiuc007efr.1. mouse. [Q5DU31-3]
uc007efs.1. mouse. [Q5DU31-2]
uc011wzm.1. mouse. [Q5DU31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157384 mRNA. Translation: BAE34075.1. Different initiation.
AK038257 mRNA. Translation: BAC29953.1. Different initiation.
AK220339 mRNA. Translation: BAD90405.1. Different initiation.
AC155718 Genomic DNA. No translation available.
AC164171 Genomic DNA. No translation available.
CCDSiCCDS56688.1. [Q5DU31-1]
RefSeqiNP_001164271.1. NM_001170800.1. [Q5DU31-1]
UniGeneiMm.331674.

3D structure databases

ProteinModelPortaliQ5DU31.
SMRiQ5DU31. Positions 17-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101242.

PTM databases

PhosphoSiteiQ5DU31.

Proteomic databases

EPDiQ5DU31.
MaxQBiQ5DU31.
PaxDbiQ5DU31.
PRIDEiQ5DU31.

Protocols and materials databases

DNASUi320495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078070; ENSMUSP00000077215; ENSMUSG00000064065. [Q5DU31-2]
ENSMUST00000105617; ENSMUSP00000101242; ENSMUSG00000064065. [Q5DU31-1]
GeneIDi320495.
KEGGimmu:320495.
UCSCiuc007efr.1. mouse. [Q5DU31-3]
uc007efs.1. mouse. [Q5DU31-2]
uc011wzm.1. mouse. [Q5DU31-1]

Organism-specific databases

CTDi26034.
MGIiMGI:2444159. Ipcef1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ5DU31.
OMAiPSEANSC.
OrthoDBiEOG71ZP0W.
TreeFamiTF326495.

Miscellaneous databases

ChiTaRSiIpcef1. mouse.
PROiQ5DU31.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DU31.
ExpressionAtlasiQ5DU31. baseline and differential.
GenevisibleiQ5DU31. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 227-406 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiICEF1_MOUSE
AccessioniPrimary (citable) accession number: Q5DU31
Secondary accession number(s): Q3TZY2, Q8CAP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.