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Protein

Interactor protein for cytohesin exchange factors 1

Gene

Ipcef1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Gene namesi
Name:Ipcef1
Synonyms:Kiaa0403
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444159 Ipcef1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003266311 – 406Interactor protein for cytohesin exchange factors 1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q5DU31-2)
Modified residuei164PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DU31
PRIDEiQ5DU31

PTM databases

iPTMnetiQ5DU31
PhosphoSitePlusiQ5DU31

Expressioni

Gene expression databases

BgeeiENSMUSG00000064065
ExpressionAtlasiQ5DU31 baseline and differential
GenevisibleiQ5DU31 MM

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101242

Structurei

3D structure databases

ProteinModelPortaliQ5DU31
SMRiQ5DU31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 112PHPROSITE-ProRule annotationAdd BLAST100

Phylogenomic databases

eggNOGiENOG410IP6N Eukaryota
ENOG41121GN LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000082484
HOVERGENiHBG107987
InParanoidiQ5DU31
OMAiSFLSNKW
OrthoDBiEOG091G037J
TreeFamiTF326495

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRRISCKD LGHADCQGWL YKKKEKGTFL SNKWKKFWVV LKGSSLYWYS
60 70 80 90 100
NQMAEKADGF VNLSDFTVER ASECKKKNAF KINHPQIKAF YFAAENLQEM
110 120 130 140 150
NVWLNKLGFA VTHQESITKD EECYSESEQE DPEVAVEAPP PPYASTTSSP
160 170 180 190 200
VAAQWASSSS PKRRETSCSF SSLENTVKAP SQFSSSGSKE RQSWHNIVNS
210 220 230 240 250
SPATEDAGLP LTFAEQVHTL AFSEASNCQA PENNCITSEG GLLNLLSSDD
260 270 280 290 300
TSSLNNNKDH LTVPDRAAGS RMADREEIKS SEDDEMEKLY KSLEQASLSP
310 320 330 340 350
LGDRRPSTKK ELRKSFVKRC KNPSINEKLH KIRTLNSTLK CKEHDLAMIN
360 370 380 390 400
QLLDDPKLTA RKYREWKVMN TLLIQDIYQQ QAPQDPEVTP QEVMNPTSSD

CVENSL
Length:406
Mass (Da):45,812
Last modified:April 8, 2008 - v2
Checksum:i866733F4E55FFB84
GO
Isoform 2 (identifier: Q5DU31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: V → VVRVD

Show »
Length:410
Mass (Da):46,282
Checksum:iA9A6EFF3E054C0E8
GO
Isoform 3 (identifier: Q5DU31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-298: EEIKSSEDDEMEKLYKSLEQASL → GKPGICLLFLDGEYLLGHCMILI
     299-406: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):33,085
Checksum:i31BD3C4EA711F46A
GO

Sequence cautioni

The sequence BAC29953 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90405 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34075 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032683151V → VVRVD in isoform 2. 1 Publication1
Alternative sequenceiVSP_032684276 – 298EEIKS…EQASL → GKPGICLLFLDGEYLLGHCM ILI in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_032685299 – 406Missing in isoform 3. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157384 mRNA Translation: BAE34075.1 Different initiation.
AK038257 mRNA Translation: BAC29953.1 Different initiation.
AK220339 mRNA Translation: BAD90405.1 Different initiation.
AC155718 Genomic DNA No translation available.
AC164171 Genomic DNA No translation available.
CCDSiCCDS56688.1 [Q5DU31-1]
CCDS83676.1 [Q5DU31-2]
RefSeqiNP_001164271.1, NM_001170800.1 [Q5DU31-1]
NP_001334154.1, NM_001347225.1 [Q5DU31-2]
UniGeneiMm.331674

Genome annotation databases

EnsembliENSMUST00000078070; ENSMUSP00000077215; ENSMUSG00000064065 [Q5DU31-2]
ENSMUST00000105617; ENSMUSP00000101242; ENSMUSG00000064065 [Q5DU31-1]
GeneIDi320495
KEGGimmu:320495
UCSCiuc007efr.1 mouse [Q5DU31-3]
uc007efs.1 mouse [Q5DU31-2]
uc011wzm.1 mouse [Q5DU31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiICEF1_MOUSE
AccessioniPrimary (citable) accession number: Q5DU31
Secondary accession number(s): Q3TZY2, Q8CAP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health