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Protein

Pecanex-like protein 2

Gene

Pcnx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in tumorigenesis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 2
Alternative name(s):
Pecanex homolog protein 2Imported
Gene namesi
Name:Pcnx2Imported
Synonyms:Kiaa0435, Pcnxl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2445010. Pcnx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5318HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8223HelicalSequence analysisAdd
BLAST
Transmembranei825 – 84521HelicalSequence analysisAdd
BLAST
Transmembranei849 – 86921HelicalSequence analysisAdd
BLAST
Transmembranei882 – 90221HelicalSequence analysisAdd
BLAST
Transmembranei933 – 95321HelicalSequence analysisAdd
BLAST
Transmembranei976 – 99823HelicalSequence analysisAdd
BLAST
Transmembranei1010 – 103021HelicalSequence analysisAdd
BLAST
Transmembranei1080 – 110021HelicalSequence analysisAdd
BLAST
Transmembranei1105 – 112521HelicalSequence analysisAdd
BLAST
Transmembranei1174 – 119421HelicalSequence analysisAdd
BLAST
Transmembranei1218 – 123821HelicalSequence analysisAdd
BLAST
Transmembranei1245 – 126521HelicalSequence analysisAdd
BLAST
Transmembranei1270 – 129021HelicalSequence analysisAdd
BLAST
Transmembranei1305 – 132521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21222122Pecanex-like protein 2PRO_0000333966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis
Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence analysis
Glycosylationi1393 – 13931N-linked (GlcNAc...)Sequence analysis
Glycosylationi1534 – 15341N-linked (GlcNAc...)Sequence analysis
Glycosylationi1802 – 18021N-linked (GlcNAc...)Sequence analysis
Glycosylationi2039 – 20391N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5DU28.
PRIDEiQ5DU28.

PTM databases

iPTMnetiQ5DU28.
PhosphoSiteiQ5DU28.

Expressioni

Gene expression databases

BgeeiQ5DU28.
GenevisibleiQ5DU28. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042294.

Structurei

3D structure databases

ProteinModelPortaliQ5DU28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1922 – 2048127Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG4111D2H. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG108237.
InParanoidiQ5DU28.
OMAiMWISHPV.
OrthoDBiEOG72VH54.
PhylomeDBiQ5DU28.
TreeFamiTF313570.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQVLQLLR QGVWAALTGG WYHDPEHSKF TNSCHLYLWL FLLLLPLALH
60 70 80 90 100
LAFPPNVLTA LFYCGSVTIF FAVIKLISYR LHLMFDKGEA IQHRSPRKRS
110 120 130 140 150
KRKPEGEASS QHTARHKNPS NNRQIHSTKK EEPRGSLTTP PLCCSSRGQS
160 170 180 190 200
VHSQHSSGPL ELPAQETVED LKGVVLSEDQ PEALASSTSP GMKSESLPAS
210 220 230 240 250
QGRTPEPTPR PACPLKPVTT ELFTARKGKE SGGTAQRPAR HRSESGLVNP
260 270 280 290 300
GALKKLPQLS LSQYDLLETD ISFQPWGSEH SVLLPQPNCT QGATRAQPQN
310 320 330 340 350
RSPQDSLSSS CCQCNTVLAK PTEEELTRTS GQVELPLNQE VVDSDGEVAV
360 370 380 390 400
TLIDTSQPGE PLSLHEPIKI VITMSSTQNS ISDLESSLHL RVTSSDRTSV
410 420 430 440 450
RSSAESAGSG GAGPADPEQV RIPLITLELT EDGGGRGVSC SEGNGGERTP
460 470 480 490 500
ERMEVMSPDR CSGSGPGDGS PTPGSTLATL TPRVDPESEG SKEGQANLDP
510 520 530 540 550
ASCKSSHEKR HARVLSVDSG TDVFLSRSTK EVVSDGEKPI PTSKSDLEAK
560 570 580 590 600
EGQIPNESNF LEFVSLLESI STSKVVAPDS PAEQKGASQG PEGHASPGTK
610 620 630 640 650
EEAVENEKPN GRDPKPGKPD LPSQDPANGS PVFTQPAKSA ALFQGSRQRH
660 670 680 690 700
IIYRVTSQQD SSVLQVISGP ETSVQEEMSL DAMHVFIDEH GEVRSCYLKS
710 720 730 740 750
GNQKEGSSQH PPLNPDCVSH ARGILLSSSS STATGSPDPS SGDPAVSALQ
760 770 780 790 800
QQLLLMVARR TQSETPRHVS QDLEDSSRSS AQGKFNREQF YKFIVFPGKW
810 820 830 840 850
IKVWYDRLTL LALLDRTEDV KENMVAVLLS VLVSLLGFLT LNRGFCRDLW
860 870 880 890 900
VLLFCLVMAS CQYSLLKSVQ PDPASPIHGH NQIIAYSRPI YFCMLCSLIL
910 920 930 940 950
LLDAGAKAKH PPSYVVYGLK LFTPETLQAV RDHLIVFLCC FPAISLLGLF
960 970 980 990 1000
PQINTFCTYL LEQIDMLLFG GSAVSGITSA VYSVGRSVLA AALLHAFCFS
1010 1020 1030 1040 1050
AVKEPWSTQH IPALFSAFCG LLVALSYHLS RQSSDPSVLL SFIQCKLLPK
1060 1070 1080 1090 1100
CLHQNLEESA TDPLPQRMKD SVKDVLRSDL VICSAAAVLS FAVSASTVFL
1110 1120 1130 1140 1150
SLRPFLSIVL FALAGTVGLI THHLLPQLRK HHPWMWISHP VLRSKEYQQR
1160 1170 1180 1190 1200
EARDIAHLMW FERLYVWLQC FEKYLLYPAI VLNALTLDAF SISNYRRLGT
1210 1220 1230 1240 1250
HWDIFLMITA GMKLLRTSFC NPVHQFANLG FTVIFFHFDY KDISESFLLD
1260 1270 1280 1290 1300
FFMVSIVFTK LGDLLQKLQF VLAYVAPWQM AWGSSFHVFA QLFAIPHSAM
1310 1320 1330 1340 1350
LFFQTFATSI FSTPLSPFLG SVIFITSYVR PVKFWERSYN TRRMDNSNTR
1360 1370 1380 1390 1400
LAVQMERDPG SDDNNLNSIF YEHLTRTLQE SLCGDLVLGR WGNYSSGDCF
1410 1420 1430 1440 1450
ILASDDLNAF VHLIEIGNGL VTFQLRGLEF RGTYCQQREV EAIMEGDEDD
1460 1470 1480 1490 1500
RGCCCCKPGH LPHLLSCNAA FHLRWLTWEI TRTQYILEGY SIIDNNAATM
1510 1520 1530 1540 1550
LQVYDLRRVL IRYYVKSIIY YMVTSPKLVS WVKNESLLKS LQPFAKWHHI
1560 1570 1580 1590 1600
ERDLAMFNIN IDDDYVPCLQ GITRASYCNV FLEWIQYCAG KRQELSKTLE
1610 1620 1630 1640 1650
HVDSDEDSAL VTLAFALCIL GRRALGTAAH NMAMSLDSFL YGLHALFKGD
1660 1670 1680 1690 1700
FRVTARDEWV FADMDLLHKV VVPAIRMSLK LHQDQFTCPD EYEDPAVLYE
1710 1720 1730 1740 1750
AIRSFAKKVV ICHEGDPAWR GAMLSNKEEL LTLRHVVDEG ADEYKVIMLH
1760 1770 1780 1790 1800
RGFLSFKVIK VNKECVRGLW AGQQQELIFL RNRNPERGSI QNNKQVLRNL
1810 1820 1830 1840 1850
INSSCDQPLG YPMYVSPLTT SYLGTHKQLQ SVWGGPVTLN RVRTWFQTRW
1860 1870 1880 1890 1900
LRMRKDCSVG QRSGGGNIED GEGGAVPSAG GGSAPNGESR DGSTEQPRKG
1910 1920 1930 1940 1950
GTQQWSSPRG EAQRAGRRKG RSQSVQAHSA ISQRPPTLSS SGPILESHQA
1960 1970 1980 1990 2000
FLQTSTSVHE LAQRPSGSRL SLHTSAASLH SQPPPVTTTG HLSVRERAEA
2010 2020 2030 2040 2050
LIRSSLGSST SSTLSFLFGK RSFSSALVIS GLSAAEGGNT SDTQSSSSVN
2060 2070 2080 2090 2100
IVMGPSARAA GHAARHFSEP CEPTDSPEQG QLQDGRLAEA MEENLGVLCR
2110 2120
RASQEDMGLD DTASQQSTSD EQ
Length:2,122
Mass (Da):234,128
Last modified:May 20, 2008 - v2
Checksum:i49D31B483000EA97
GO
Isoform 2 (identifier: Q5DU28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1067: Missing.
     1452-1452: G → GC

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):118,642
Checksum:i2DA67278663BB83E
GO
Isoform 3 (identifier: Q5DU28-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1073-1121: KDVLRSDLVI...ALAGTVGLIT → VRPQHGKTAC...VQSRLISRDT
     1122-2122: Missing.

Note: No experimental confirmation available.
Show »
Length:1,121
Mass (Da):121,226
Checksum:i6A66D05260C98E3E
GO
Isoform 4 (identifier: Q5DU28-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1443: Missing.

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):75,239
Checksum:iB079D92A439D7331
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14431443Missing in isoform 4. 1 PublicationVSP_033612Add
BLAST
Alternative sequencei1 – 10671067Missing in isoform 2. 1 PublicationVSP_033613Add
BLAST
Alternative sequencei1073 – 112149KDVLR…VGLIT → VRPQHGKTACHRGPCLSAGM KLPGYSELAGSGKAGGGPWV QSRLISRDT in isoform 3. 2 PublicationsVSP_033614Add
BLAST
Alternative sequencei1122 – 21221001Missing in isoform 3. 2 PublicationsVSP_033615Add
BLAST
Alternative sequencei1452 – 14521G → GC in isoform 2. 1 PublicationVSP_033616

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030215 mRNA. Translation: BAC26849.1.
AK043903 mRNA. Translation: BAC31698.1.
AK087907 mRNA. Translation: BAC40038.1.
AC105066 Genomic DNA. No translation available.
AC151909 Genomic DNA. No translation available.
BC132334 mRNA. Translation: AAI32335.2.
AK220342 mRNA. Translation: BAD90408.1.
CCDSiCCDS52708.1. [Q5DU28-1]
RefSeqiNP_780770.2. NM_175561.4. [Q5DU28-1]
UniGeneiMm.145535.

Genome annotation databases

EnsembliENSMUST00000047239; ENSMUSP00000042294; ENSMUSG00000060212. [Q5DU28-1]
ENSMUST00000131127; ENSMUSP00000119965; ENSMUSG00000060212. [Q5DU28-3]
GeneIDi270109.
KEGGimmu:270109.
UCSCiuc009nyl.1. mouse. [Q5DU28-4]
uc009nym.1. mouse. [Q5DU28-2]
uc009nyn.2. mouse. [Q5DU28-1]
uc009nyo.1. mouse. [Q5DU28-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030215 mRNA. Translation: BAC26849.1.
AK043903 mRNA. Translation: BAC31698.1.
AK087907 mRNA. Translation: BAC40038.1.
AC105066 Genomic DNA. No translation available.
AC151909 Genomic DNA. No translation available.
BC132334 mRNA. Translation: AAI32335.2.
AK220342 mRNA. Translation: BAD90408.1.
CCDSiCCDS52708.1. [Q5DU28-1]
RefSeqiNP_780770.2. NM_175561.4. [Q5DU28-1]
UniGeneiMm.145535.

3D structure databases

ProteinModelPortaliQ5DU28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042294.

PTM databases

iPTMnetiQ5DU28.
PhosphoSiteiQ5DU28.

Proteomic databases

PaxDbiQ5DU28.
PRIDEiQ5DU28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047239; ENSMUSP00000042294; ENSMUSG00000060212. [Q5DU28-1]
ENSMUST00000131127; ENSMUSP00000119965; ENSMUSG00000060212. [Q5DU28-3]
GeneIDi270109.
KEGGimmu:270109.
UCSCiuc009nyl.1. mouse. [Q5DU28-4]
uc009nym.1. mouse. [Q5DU28-2]
uc009nyn.2. mouse. [Q5DU28-1]
uc009nyo.1. mouse. [Q5DU28-3]

Organism-specific databases

CTDi80003.
MGIiMGI:2445010. Pcnx2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG4111D2H. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG108237.
InParanoidiQ5DU28.
OMAiMWISHPV.
OrthoDBiEOG72VH54.
PhylomeDBiQ5DU28.
TreeFamiTF313570.

Miscellaneous databases

PROiQ5DU28.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DU28.
GenevisibleiQ5DU28. MM.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-2122 (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Brain cortex, Ovary and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-2122 (ISOFORM 3).
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-2122 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiPCX2_MOUSE
AccessioniPrimary (citable) accession number: Q5DU28
Secondary accession number(s): A2RT20
, Q8BRN0, Q8C2V1, Q8CDD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.