IQ motif and SEC7 domain-containing protein 2

Preferred order of sections

Names and origin

Protein names

Recommended name:
IQ motif and SEC7 domain-containing protein 2

Gene names

Name:	Iqsec2
Synonyms:	Kiaa0522

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the BRAG family.

Contains 1 IQ domain.

Contains 1 PH domain.

Contains 1 SEC7 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of ARF protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	ARF guanyl-nucleotide exchange factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1478

1478

IQ motif and SEC7 domain-containing protein 2

PRO_0000245609

Regions

Domain

337 – 366

30

IQ

Domain

736 – 929

194

SEC7

Domain

941 – 1075

135

PH

Coiled coil

23 – 74

52

Potential

Compositional bias

299 – 302

4

Poly-Glu

Compositional bias

513 – 656

144

Pro-rich

Compositional bias

1164 – 1471

308

Pro-rich

Compositional bias

1229 – 1241

13

His-rich

Amino acid modifications

Modified residue

82

1

Phosphoserine Ref.3

Modified residue

89

1

Phosphotyrosine Ref.3

Modified residue

383

1

Phosphoserine Ref.4

Modified residue

402

1

Phosphoserine Ref.4

Modified residue

611

1

Phosphotyrosine Ref.3

Modified residue

923

1

Phosphotyrosine Ref.3

Modified residue

1119

1

Phosphotyrosine Ref.3

Experimental info

Sequence conflict

833

1

H → L in BAD90410. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q5DU25 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: E61C5F88BBF34578
Show »

FASTA

1,478

161,787

        10         20         30         40         50         60 
MEAGSGPPGG PGSESPNRAV EYLLELNNII ESQQQLLETQ RRRIEELEGQ LDQLTQENRD 

        70         80         90        100        110        120 
LREESQLHRG ELHRDPLGAR DSPGRESQYQ NLRETQFHHR ELRESQFHQA SRDVGYPNRD 

       130        140        150        160        170        180 
GAYQNREAIY RDKEREASYQ LQDTTGYTAR ERDVAQCHLH HENPALGRER GGREAGPAHP 

       190        200        210        220        230        240 
GREKEAGYSA AVGVGQRPPR ERGQLSRGAS RSSSPGAGGG HSTSTSTSPA TTLQRNVEGD 

       250        260        270        280        290        300 
APGSDLSTAV DSPGSQPPYR LSQLPPTSSH MGGPPAGVGL PWAQRARLQP ASVALRKQEE 

       310        320        330        340        350        360 
EEIKRSKALS DSYELSTDLQ DKKVEMLERK YGGSFLSRRA ARTIQTAFRQ YRMNKNFERL 

       370        380        390        400        410        420 
RSSASESRMS RRIILSNMRM QFSFEEYEKA QNPAYFEGKP ASLDEGAMAG ARSHRLERGL 

       430        440        450        460        470        480 
PYGGSCGGGI DGGGSSVTTS GEFSNDITEL EDSFSKQVKS LAESIDEALN CHPSGPMSEE 

       490        500        510        520        530        540 
PGSAQLEKRE SKEQQEDSSA TSFSDLPLYL DDPVPPPSPE RLPSTEPPPQ GRPEFWAPAP 

       550        560        570        580        590        600 
LPPVPPPMPP GTREDGSREE GTRRGPGCLE CRDFRLRAAH LPLLTIEPPS DSSVDLSDRS 

       610        620        630        640        650        660 
DRGSVHRQLV YEADGCSPHG TLKHKGPPGR APIPHRHYPA PEGPAPAPPG PLPPAPNSGT 

       670        680        690        700        710        720 
GPSGVAGGRR LGKCEAAGEN SDGGDNESLE SSSNSNETIN CSSGSSSRDS LREPPATGLC 

       730        740        750        760        770        780 
KQTYQRETRH SWDSPAFNND VVQRRHYRIG LNLFNKKPEK GIQYLIERGF LSDTPVGVAH 

       790        800        810        820        830        840 
FILERKGLSR QMIGEFLGNR QKQFNRDVLD CVVDEMDFSS MDLDDALRKF QSHIRVQGEA 

       850        860        870        880        890        900 
QKVERLIEAF SQRYCVCNPA LVRQFRNPDT IFILAFAIIL LNTDMYSPSV KAERKMKLDD 

       910        920        930        940        950        960 
FIKNLRGVDN GEDIPRDLLV GIYQRIQGRE LRTNDDHVSQ VQAVERMIVG KKPVLSLPHR 

       970        980        990       1000       1010       1020 
RLVCCCQLYE VPDPNRPQRL GLHQREVFLF NDLLVVTKIF QKKKILVTYS FRQSFPLVEM 

      1030       1040       1050       1060       1070       1080 
HMQLFQNSYY QFGIKLLSAV PGGERKVLII FNAPSLQDRL RFTSDLRESI AEVQEMEKYR 

      1090       1100       1110       1120       1130       1140 
VESELEKQKG MMRPNASQPG GAKDSVNGTL ARSSLEDTYG AGDGLKRGAL SSSLRDLSDA 

      1150       1160       1170       1180       1190       1200 
GKRGRRNSVG SLDSTIEGSV ISSPRPHQRM PPPPPPPPPE EYKSQRPVSN SSSFLGSLFG 

      1210       1220       1230       1240       1250       1260 
SKRGKGPFQM PPPPTGQASA SSSSASSTHH HHHHHHHGHS HGGLGVLPDG QSKLQALHAQ 

      1270       1280       1290       1300       1310       1320 
YCQGPGPAPP PYLPPQQPPL PPPPQQPPPL PQLGSIPPPP ASAPPVGPHR HFHAHGPVPG 

      1330       1340       1350       1360       1370       1380 
PQHYTLGRPG RAPRRGAGGH PQFAPHGRHP LHQPTSPLPL YSPAPQHPPA HKQGPKHFIF 

      1390       1400       1410       1420       1430       1440 
SHHPQMMPAA GAAGGPGSRP PGGSYSHPHH PQSPLSPHSP IPPHPSYPPL PPPSPHTPHS 

      1450       1460       1470 
PLPPTSPHGP LHASGPPGTA NPPSANPKAK PSRISTVV

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References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 833-1478. Tissue: Brain.
[3]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; TYR-89; TYR-611; TYR-923 AND TYR-1119, MASS SPECTROMETRY. Tissue: Brain.
[4]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND SER-402, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC083816 Genomic DNA. No translation available. AK220345 mRNA. Translation: BAD90410.1.
IPI	IPI00758248.
RefSeq	NP_001108136.1. NM_001114664.1.
UniGene	Mm.33027.
3D structure databases
ProteinModelPortal	Q5DU25.
SMR	Q5DU25. Positions 739-1088.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5DU25. 2 interactions.
STRING	Q5DU25.
PTM databases
PhosphoSite	Q5DU25.
Proteomic databases
PRIDE	Q5DU25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000080074; ENSMUSP00000078978; ENSMUSG00000041115.
GeneID	245666.
KEGG	mmu:245666.
Organism-specific databases
CTD	23096.
MGI	MGI:3528396. Iqsec2.
Rouge	Search...
Phylogenomic databases
eggNOG	roNOG05999.
GeneTree	ENSGT00590000083058.
HOVERGEN	HBG056324.
Gene expression databases
ArrayExpress	Q5DU25.
Bgee	Q5DU25.
CleanEx	MM_IQSEC2.
Genevestigator	Q5DU25.
GermOnline	ENSMUSG00000041115. Mus musculus.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR000904. Sec7. IPR023394. SEC7_alpha_orthog. [Graphical view]
Gene3D	G3DSA:1.10.1000.11. G3DSA:1.10.1000.11. 1 hit. G3DSA:2.30.29.30. PH_type. 1 hit.
KO	K12495.
Pfam	PF01369. Sec7. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00222. Sec7. 1 hit. [Graphical view]
SUPFAM	SSF48425. Sec7. 1 hit.
PROSITE	PS50096. IQ. 1 hit. PS50003. PH_DOMAIN. False negative. PS50190. SEC7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

IQEC2_MOUSE

Accession

Primary (citable) accession number: Q5DU25
Secondary accession number(s): E9QK46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 27, 2011
Last modified:	November 16, 2011
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents