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Protein

Zinc finger protein 652

Gene

Znf652

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:Znf652
Synonyms:Kiaa0924, Zfp652
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442221. Zfp652.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804291 – 608Zinc finger protein 652Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei196PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DU09.
PRIDEiQ5DU09.

PTM databases

iPTMnetiQ5DU09.
PhosphoSitePlusiQ5DU09.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075595.
CleanExiMM_ZFP652.
ExpressionAtlasiQ5DU09. baseline and differential.
GenevisibleiQ5DU09. MM.

Interactioni

Subunit structurei

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089153.

Structurei

3D structure databases

ProteinModelPortaliQ5DU09.
SMRiQ5DU09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni497 – 608Mediates interaction with CBFA2T3By similarityAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 108Poly-Glu5
Compositional biasi194 – 200Poly-Ala7
Compositional biasi496 – 574Pro-richAdd BLAST79

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiQ5DU09.
OMAiFYHGASQ.
OrthoDBiEOG091G055W.
PhylomeDBiQ5DU09.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYTASPCPE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADTKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEDEEETEEE ATDNSSDYGE NGRQKKKEKQ VERVRVTQRR TRRAASAAAA
210 220 230 240 250
TTSPAPRTTR GRRKSAELPK RKKRATKEAK APVQKAKCEE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MSPVGAVLPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHAH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN

SAAPAQHH
Length:608
Mass (Da):69,441
Last modified:March 20, 2007 - v2
Checksum:i501DA89A7E92289F
GO
Isoform 2 (identifier: Q5DU09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-350: CVSCNKSFKK...AHVRKHMVAH → VGLTSGGQSF...CCLGLFKTKA
     351-608: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,027
Checksum:i315DC9FA56C4BEE9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023669300 – 350CVSCN…HMVAH → VGLTSGGQSFQARTWLFRVI WCLPKRIEAEGTDFTNYHFR LCCLGLFKTKA in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_023670351 – 608Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220361 mRNA. Translation: BAD90422.1.
AL593858 Genomic DNA. Translation: CAM15507.1.
BC055752 mRNA. Translation: AAH55752.1.
CCDSiCCDS36287.1. [Q5DU09-1]
RefSeqiNP_963903.2. NM_201609.2. [Q5DU09-1]
UniGeneiMm.389038.
Mm.418731.

Genome annotation databases

EnsembliENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595. [Q5DU09-1]
ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595. [Q5DU09-1]
GeneIDi268469.
KEGGimmu:268469.
UCSCiuc007laq.1. mouse. [Q5DU09-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220361 mRNA. Translation: BAD90422.1.
AL593858 Genomic DNA. Translation: CAM15507.1.
BC055752 mRNA. Translation: AAH55752.1.
CCDSiCCDS36287.1. [Q5DU09-1]
RefSeqiNP_963903.2. NM_201609.2. [Q5DU09-1]
UniGeneiMm.389038.
Mm.418731.

3D structure databases

ProteinModelPortaliQ5DU09.
SMRiQ5DU09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089153.

PTM databases

iPTMnetiQ5DU09.
PhosphoSitePlusiQ5DU09.

Proteomic databases

PaxDbiQ5DU09.
PRIDEiQ5DU09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595. [Q5DU09-1]
ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595. [Q5DU09-1]
GeneIDi268469.
KEGGimmu:268469.
UCSCiuc007laq.1. mouse. [Q5DU09-1]

Organism-specific databases

CTDi268469.
MGIiMGI:2442221. Zfp652.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiQ5DU09.
OMAiFYHGASQ.
OrthoDBiEOG091G055W.
PhylomeDBiQ5DU09.
TreeFamiTF332655.

Miscellaneous databases

PROiQ5DU09.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075595.
CleanExiMM_ZFP652.
ExpressionAtlasiQ5DU09. baseline and differential.
GenevisibleiQ5DU09. MM.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN652_MOUSE
AccessioniPrimary (citable) accession number: Q5DU09
Secondary accession number(s): A2A617, Q7TNT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.