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Q5DU05

- CE164_MOUSE

UniProt

Q5DU05 - CE164_MOUSE

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Protein

Centrosomal protein of 164 kDa

Gene
Cep164, Kiaa1052
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 By similarity.By similarity1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. DNA repair Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cilium biogenesis/degradation, DNA damage, DNA repair, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 164 kDa
Short name:
Cep164
Gene namesi
Name:Cep164
Synonyms:Kiaa1052
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2384878. Cep164.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Nucleus By similarity
Note: Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis By similarity. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 By similarity.1 Publication

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. cilium Source: MGI
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14461446Centrosomal protein of 164 kDaPRO_0000370737Add
BLAST

Proteomic databases

PaxDbiQ5DU05.
PRIDEiQ5DU05.

PTM databases

PhosphoSiteiQ5DU05.

Expressioni

Gene expression databases

GenevestigatoriQ5DU05.

Interactioni

Subunit structurei

Interacts (via N-terminus) with ATRIP. Interacts with ATM, ATR and MDC1. Interacts with XPA (via N-terminus) upon UV irradiation By similarity. Interacts with CEP83, CCDC92, TTBK2, DVL3, NPHP3 and weakly with NPHP4 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5DU05.
SMRiQ5DU05. Positions 55-88.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 8934WWAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 195195Interaction with ATRIP By similarityBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1143 – 119755 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi110 – 13021Lys-richAdd
BLAST
Compositional biasi525 – 896372Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 WW domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73730.
HOGENOMiHOG000111523.
InParanoidiQ3TYF9.
PhylomeDBiQ5DU05.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 12 Publications (identifier: Q5DU05-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARRPILLGD QLVLEEDSDE TYVPSEQEIL DFARVIGIDP IKEPELMWLA     50
REGIEAPLPK GWKPCQNITG DLYYFNFDTG QSIWDHPCDE HYRKLVIQER 100
ERWSAPGAIK KKDKKKKKEK KNKKDKETSK SPLVLGSPLA LVQAPLWGLA 150
PLRGLGDAPP SALRGSQSVS LGSSADSGHL GEPTLPPQGL KAAACAKGLL 200
ASVHEGKNAL SLLTLGEETN EEDEEESDNQ SVRSSSELLK NLHLDLGALG 250
GNFEYEESPR TSQPDKKDVS LDSDADRPPT PGKLFSQGAD SSVASANGSK 300
SQGRGASPWN PQKENENSDP KASSSQMAPE LDPGGDQPSR ASKKQQAEDP 350
VQAGKEGECR RESAAKEPKE ASALENTSDV SEESEIHGHL KDARHSGSEA 400
SGPKSFLGLD LGFRSRISEH LLDGDTLSPV LGGGHWEAQG LDQEEQDDSK 450
SSIAEPQSKH TQGSEREHLQ SSLHSQATEE GPLQTLEGQP EWKEAEGPGK 500
DSVASPAPLS LLQREQVLSP PASPERAEEK HSQAEELGLE QPEAEETEEK 550
VAVCPSSPVS PEVQTAEPAA PQKLFSEAIL KGMELEEDQR LLLEFQKEKP 600
QQLEERLWEE EEEEVCQLYQ QKEKSLSLLK AQLQKATAEE KEKEEETKIR 650
EEESRRLVCL RAQVQSRTEA FENQIRTEQQ AALQRLREEA ETLQKAERAS 700
LEQKSRRALE QLREQLEAEE RSAQAALRAE KEAEKEAALL QLREQLEGER 750
KEAVAGLEKK HSAELEQLCS SLEAKHQEVI SSLQKKIEGA QQKEEAQLQE 800
SLGWAEQRAH QKVHQVTEYE QELSSLLRDK RQEVEREHER KMDKMKEEHW 850
QEMADARERY EAEERKQRAD LLGHLTGELE RLRRAHEREL ESMRQEQDQQ 900
LEDLRRRHRD HERKLQDLEV ELSSRTKDVK ARLAQLNVQE ENIRKEKQLL 950
LDAQRQAALE REEATATHQH LEEAKKEHTH LLETKQQLRR TIDDLRVRRV 1000
ELESQVDLLQ AQSQRLQKHL SSLEAEVQRK QDVLKEMAAE MNASPHPEPG 1050
LHIEDLRKSL DTNKNQEVSS SLSLSKEEID LSMESVRQFL SAEGVAVRNA 1100
KEFLVRQTRS MRRRQTALKA AQQHWRHELA SAQEVDEDLP GTEVLGNMRK 1150
NLNEETRHLD EMKSAMRKGH DLLKKKEEKL IQLESSLQEE VSDEDTLKGS 1200
SIKKVTFDLS DMDDLSSESL ESSPVLHITP TPTSADPNKI HYLSSSLQRI 1250
SSELNGVLNV LGSLNSQPPP QGLGSQPPPP LFTSSLRSSK NVLDPAYSSQ 1300
AKLSSLSSIT PMSTQWAWDP GQGTKLTSSS SSQTVDDFLL EKWRKYFPSG 1350
IPLLSGSPPP PENKLGYVSV SEQLHFLQRS HPRVPRTDGV SIQSLIDSNR 1400
KWLEHFRNDP KVQLFSSAPK ATTTSNLSNL LQLGLDENNR LNVFHY 1446

Note: Gene prediction based on similarity to human ortholog.

Length:1,446
Mass (Da):162,601
Last modified:May 5, 2009 - v2
Checksum:i14EB2ED0166C0FDE
GO
Isoform 23 Publications (identifier: Q5DU05-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-188: Missing.
     514-626: Missing.

Note: No experimental confirmation available.

Show »
Length:1,330
Mass (Da):149,310
Checksum:i014A877BB139F3E9
GO
Isoform 31 Publication (identifier: Q5DU05-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-563: Missing.
     604-608: EERLW → EDEEEEGEEEEEEEEKEEEEE

Note: No experimental confirmation available.

Show »
Length:1,413
Mass (Da):159,245
Checksum:i5921B9CA75C4B5EC
GO

Sequence cautioni

The sequence AAH66145.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC34489.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 1883Missing in isoform 2. 3 PublicationsVSP_053075
Alternative sequencei514 – 626113Missing in isoform 2. VSP_053077Add
BLAST
Alternative sequencei515 – 56349Missing in isoform 3. VSP_053078Add
BLAST
Alternative sequencei604 – 6085EERLW → EDEEEEGEEEEEEEEKEEEE E in isoform 3. VSP_053079

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1021 – 10211Missing in BAD90247. 1 Publication
Sequence conflicti1025 – 10251A → V in AAH66145. 1 Publication
Sequence conflicti1192 – 11921S → P in AAH66145. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126804 Genomic DNA. No translation available.
AK032890 mRNA. Translation: BAC28073.1.
AK050991 mRNA. Translation: BAC34489.1. Different initiation.
AK158671 mRNA. Translation: BAE34604.1.
AK220365 mRNA. Translation: BAD90247.1.
BC066145 mRNA. Translation: AAH66145.1. Different initiation.
UniGeneiMm.260103.

Genome annotation databases

UCSCiuc009pgb.2. mouse. [Q5DU05-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126804 Genomic DNA. No translation available.
AK032890 mRNA. Translation: BAC28073.1 .
AK050991 mRNA. Translation: BAC34489.1 . Different initiation.
AK158671 mRNA. Translation: BAE34604.1 .
AK220365 mRNA. Translation: BAD90247.1 .
BC066145 mRNA. Translation: AAH66145.1 . Different initiation.
UniGenei Mm.260103.

3D structure databases

ProteinModelPortali Q5DU05.
SMRi Q5DU05. Positions 55-88.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5DU05.

Proteomic databases

PaxDbi Q5DU05.
PRIDEi Q5DU05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009pgb.2. mouse. [Q5DU05-2 ]

Organism-specific databases

MGIi MGI:2384878. Cep164.
Rougei Search...

Phylogenomic databases

eggNOGi NOG73730.
HOGENOMi HOG000111523.
InParanoidi Q3TYF9.
PhylomeDBi Q5DU05.

Miscellaneous databases

ChiTaRSi CEP164. mouse.
PROi Q5DU05.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5DU05.

Family and domain databases

InterProi IPR001202. WW_dom.
[Graphical view ]
Pfami PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-862 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1028-1446 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Visual cortex and Wolffian duct.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-1446 (ISOFORM 2).
    Tissue: Fetal brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 909-1446 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling."
    Chaki M., Airik R., Ghosh A.K., Giles R.H., Chen R., Slaats G.G., Wang H., Hurd T.W., Zhou W., Cluckey A., Gee H.Y., Ramaswami G., Hong C.J., Hamilton B.A., Cervenka I., Ganji R.S., Bryja V., Arts H.H.
    , van Reeuwijk J., Oud M.M., Letteboer S.J., Roepman R., Husson H., Ibraghimov-Beskrovnaya O., Yasunaga T., Walz G., Eley L., Sayer J.A., Schermer B., Liebau M.C., Benzing T., Le Corre S., Drummond I., Janssen S., Allen S.J., Natarajan S., O'Toole J.F., Attanasio M., Saunier S., Antignac C., Koenekoop R.K., Ren H., Lopez I., Nayir A., Stoetzel C., Dollfus H., Massoudi R., Gleeson J.G., Andreoli S.P., Doherty D.G., Lindstrad A., Golzio C., Katsanis N., Pape L., Abboud E.B., Al-Rajhi A.A., Lewis R.A., Omran H., Lee E.Y., Wang S., Sekiguchi J.M., Saunders R., Johnson C.A., Garner E., Vanselow K., Andersen J.S., Shlomai J., Nurnberg G., Nurnberg P., Levy S., Smogorzewska A., Otto E.A., Hildebrandt F.
    Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCE164_MOUSE
AccessioniPrimary (citable) accession number: Q5DU05
Secondary accession number(s): Q3TYF9
, Q6NZG6, Q8BQD2, Q8BSI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi