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Q5DU05 (CE164_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrosomal protein of 164 kDa

Short name=Cep164
Gene names
Name:Cep164
Synonyms:Kiaa1052
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 By similarity. Ref.5 UniProtKB Q9UPV0

Subunit structure

Interacts (via N-terminus) with ATRIP. Interacts with ATM, ATR and MDC1. Interacts with XPA (via N-terminus) upon UV irradiation By similarity. Interacts with CEP83, CCDC92, TTBK2, DVL3, NPHP3 and weakly with NPHP4 By similarity. UniProtKB Q9UPV0

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Nucleus By similarity. Note: Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis By similarity. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 By similarity. Ref.5

Sequence similarities

Contains 1 WW domain.

Sequence caution

The sequence AAH66145.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC34489.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 Ref.4 (identifier: Q5DU05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene prediction based on similarity to human ortholog.
Isoform 2 Ref.2 Ref.3 Ref.4 (identifier: Q5DU05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     186-188: Missing.
     514-626: Missing.
Note: No experimental confirmation available.
Isoform 3 Ref.2 (identifier: Q5DU05-3)

The sequence of this isoform differs from the canonical sequence as follows:
     515-563: Missing.
     604-608: EERLW → EDEEEEGEEEEEEEEKEEEEE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14461446Centrosomal protein of 164 kDa
PRO_0000370737

Regions

Domain56 – 8934WW
Region1 – 195195Interaction with ATRIP By similarity UniProtKB Q9UPV0
Coiled coil1143 – 119755 Potential
Compositional bias110 – 13021Lys-rich
Compositional bias525 – 896372Glu-rich

Natural variations

Alternative sequence186 – 1883Missing in isoform 2. Ref.2 Ref.3 Ref.4
VSP_053075
Alternative sequence514 – 626113Missing in isoform 2.
VSP_053077
Alternative sequence515 – 56349Missing in isoform 3.
VSP_053078
Alternative sequence604 – 6085EERLW → EDEEEEGEEEEEEEEKEEEE E in isoform 3.
VSP_053079

Experimental info

Sequence conflict10211Missing in BAD90247. Ref.3
Sequence conflict10251A → V in AAH66145. Ref.4
Sequence conflict11921S → P in AAH66145. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 14EB2ED0166C0FDE

FASTA1,446162,601
        10         20         30         40         50         60 
MARRPILLGD QLVLEEDSDE TYVPSEQEIL DFARVIGIDP IKEPELMWLA REGIEAPLPK 

        70         80         90        100        110        120 
GWKPCQNITG DLYYFNFDTG QSIWDHPCDE HYRKLVIQER ERWSAPGAIK KKDKKKKKEK 

       130        140        150        160        170        180 
KNKKDKETSK SPLVLGSPLA LVQAPLWGLA PLRGLGDAPP SALRGSQSVS LGSSADSGHL 

       190        200        210        220        230        240 
GEPTLPPQGL KAAACAKGLL ASVHEGKNAL SLLTLGEETN EEDEEESDNQ SVRSSSELLK 

       250        260        270        280        290        300 
NLHLDLGALG GNFEYEESPR TSQPDKKDVS LDSDADRPPT PGKLFSQGAD SSVASANGSK 

       310        320        330        340        350        360 
SQGRGASPWN PQKENENSDP KASSSQMAPE LDPGGDQPSR ASKKQQAEDP VQAGKEGECR 

       370        380        390        400        410        420 
RESAAKEPKE ASALENTSDV SEESEIHGHL KDARHSGSEA SGPKSFLGLD LGFRSRISEH 

       430        440        450        460        470        480 
LLDGDTLSPV LGGGHWEAQG LDQEEQDDSK SSIAEPQSKH TQGSEREHLQ SSLHSQATEE 

       490        500        510        520        530        540 
GPLQTLEGQP EWKEAEGPGK DSVASPAPLS LLQREQVLSP PASPERAEEK HSQAEELGLE 

       550        560        570        580        590        600 
QPEAEETEEK VAVCPSSPVS PEVQTAEPAA PQKLFSEAIL KGMELEEDQR LLLEFQKEKP 

       610        620        630        640        650        660 
QQLEERLWEE EEEEVCQLYQ QKEKSLSLLK AQLQKATAEE KEKEEETKIR EEESRRLVCL 

       670        680        690        700        710        720 
RAQVQSRTEA FENQIRTEQQ AALQRLREEA ETLQKAERAS LEQKSRRALE QLREQLEAEE 

       730        740        750        760        770        780 
RSAQAALRAE KEAEKEAALL QLREQLEGER KEAVAGLEKK HSAELEQLCS SLEAKHQEVI 

       790        800        810        820        830        840 
SSLQKKIEGA QQKEEAQLQE SLGWAEQRAH QKVHQVTEYE QELSSLLRDK RQEVEREHER 

       850        860        870        880        890        900 
KMDKMKEEHW QEMADARERY EAEERKQRAD LLGHLTGELE RLRRAHEREL ESMRQEQDQQ 

       910        920        930        940        950        960 
LEDLRRRHRD HERKLQDLEV ELSSRTKDVK ARLAQLNVQE ENIRKEKQLL LDAQRQAALE 

       970        980        990       1000       1010       1020 
REEATATHQH LEEAKKEHTH LLETKQQLRR TIDDLRVRRV ELESQVDLLQ AQSQRLQKHL 

      1030       1040       1050       1060       1070       1080 
SSLEAEVQRK QDVLKEMAAE MNASPHPEPG LHIEDLRKSL DTNKNQEVSS SLSLSKEEID 

      1090       1100       1110       1120       1130       1140 
LSMESVRQFL SAEGVAVRNA KEFLVRQTRS MRRRQTALKA AQQHWRHELA SAQEVDEDLP 

      1150       1160       1170       1180       1190       1200 
GTEVLGNMRK NLNEETRHLD EMKSAMRKGH DLLKKKEEKL IQLESSLQEE VSDEDTLKGS 

      1210       1220       1230       1240       1250       1260 
SIKKVTFDLS DMDDLSSESL ESSPVLHITP TPTSADPNKI HYLSSSLQRI SSELNGVLNV 

      1270       1280       1290       1300       1310       1320 
LGSLNSQPPP QGLGSQPPPP LFTSSLRSSK NVLDPAYSSQ AKLSSLSSIT PMSTQWAWDP 

      1330       1340       1350       1360       1370       1380 
GQGTKLTSSS SSQTVDDFLL EKWRKYFPSG IPLLSGSPPP PENKLGYVSV SEQLHFLQRS 

      1390       1400       1410       1420       1430       1440 
HPRVPRTDGV SIQSLIDSNR KWLEHFRNDP KVQLFSSAPK ATTTSNLSNL LQLGLDENNR 


LNVFHY 

« Hide

Isoform 2 [UniParc].

Checksum: 014A877BB139F3E9
Show »

FASTA1,330149,310
Isoform 3 [UniParc].

Checksum: 5921B9CA75C4B5EC
Show »

FASTA1,413159,245

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-862 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1028-1446 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Embryo, Visual cortex and Wolffian duct.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-1446 (ISOFORM 2).
Tissue: Fetal brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 909-1446 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Embryo.
[5]"Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling."
Chaki M., Airik R., Ghosh A.K., Giles R.H., Chen R., Slaats G.G., Wang H., Hurd T.W., Zhou W., Cluckey A., Gee H.Y., Ramaswami G., Hong C.J., Hamilton B.A., Cervenka I., Ganji R.S., Bryja V., Arts H.H. expand/collapse author list , van Reeuwijk J., Oud M.M., Letteboer S.J., Roepman R., Husson H., Ibraghimov-Beskrovnaya O., Yasunaga T., Walz G., Eley L., Sayer J.A., Schermer B., Liebau M.C., Benzing T., Le Corre S., Drummond I., Janssen S., Allen S.J., Natarajan S., O'Toole J.F., Attanasio M., Saunier S., Antignac C., Koenekoop R.K., Ren H., Lopez I., Nayir A., Stoetzel C., Dollfus H., Massoudi R., Gleeson J.G., Andreoli S.P., Doherty D.G., Lindstrad A., Golzio C., Katsanis N., Pape L., Abboud E.B., Al-Rajhi A.A., Lewis R.A., Omran H., Lee E.Y., Wang S., Sekiguchi J.M., Saunders R., Johnson C.A., Garner E., Vanselow K., Andersen J.S., Shlomai J., Nurnberg G., Nurnberg P., Levy S., Smogorzewska A., Otto E.A., Hildebrandt F.
Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC126804 Genomic DNA. No translation available.
AK032890 mRNA. Translation: BAC28073.1.
AK050991 mRNA. Translation: BAC34489.1. Different initiation.
AK158671 mRNA. Translation: BAE34604.1.
AK220365 mRNA. Translation: BAD90247.1.
BC066145 mRNA. Translation: AAH66145.1. Different initiation.
UniGeneMm.260103.

3D structure databases

ProteinModelPortalQ5DU05.
SMRQ5DU05. Positions 55-88.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5DU05.

Proteomic databases

PaxDbQ5DU05.
PRIDEQ5DU05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009pgb.2. mouse. [Q5DU05-2]

Organism-specific databases

MGIMGI:2384878. Cep164.
RougeSearch...

Phylogenomic databases

eggNOGNOG73730.
HOGENOMHOG000111523.
InParanoidQ3TYF9.
PhylomeDBQ5DU05.

Gene expression databases

GenevestigatorQ5DU05.

Family and domain databases

InterProIPR001202. WW_dom.
[Graphical view]
PfamPF00397. WW. 1 hit.
[Graphical view]
SMARTSM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCEP164. mouse.
PROQ5DU05.
SOURCESearch...

Entry information

Entry nameCE164_MOUSE
AccessionPrimary (citable) accession number: Q5DU05
Secondary accession number(s): Q3TYF9 expand/collapse secondary AC list , Q6NZG6, Q8BQD2, Q8BSI0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot