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Q5DU02

- UBP22_MOUSE

UniProt

Q5DU02 - UBP22_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 22

Gene

Usp22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851NucleophilePROSITE-ProRule annotation
Active sitei479 – 4791Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri61 – 12161UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: Ensembl
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  3. ubiquitin-specific protease activity Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. histone deubiquitination Source: Ensembl
  3. histone ubiquitination Source: Ensembl
  4. positive regulation of mitotic cell cycle Source: Ensembl
  5. positive regulation of transcription, DNA-templated Source: Ensembl
  6. protein deubiquitination Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Protein family/group databases

MEROPSiC19.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 22 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 22
Ubiquitin thioesterase 22
Ubiquitin-specific-processing protease 22
Gene namesi
Name:Usp22
Synonyms:Kiaa1063
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2144157. Usp22.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. SAGA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Ubiquitin carboxyl-terminal hydrolase 22PRO_0000080651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5DU02.
PaxDbiQ5DU02.
PRIDEiQ5DU02.

PTM databases

PhosphoSiteiQ5DU02.

Expressioni

Tissue specificityi

Highly expressed in brain and weakly in other organs.1 Publication

Developmental stagei

Highly expressed between E10.5 and E12.5. Expressed in the midbrain, forebrain, hindbrain and dorsal root ganglia of embryos at E12.5.1 Publication

Gene expression databases

BgeeiQ5DU02.
CleanExiMM_USP22.
ExpressionAtlasiQ5DU02. baseline and differential.
GenevestigatoriQ5DU02.

Interactioni

Subunit structurei

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5DU02. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5DU02.
SMRiQ5DU02. Positions 76-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 520345USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. UBP8 subfamily.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri61 – 12161UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00760000119203.
HOVERGENiHBG058014.
InParanoidiQ5DU02.
KOiK11366.
OMAiYCQMCDD.
OrthoDBiEOG7FR7G7.
PhylomeDBiQ5DU02.
TreeFamiTF323554.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5DU02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVARPEPEVE AMDAELAVPP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT
60 70 80 90 100
AEARKRKAKS CVCHVCGIHL NRLHSCLYCV FFGCFTKKHI HDHAKSKRHN
110 120 130 140 150
LAIDLMYGGI YCFLCQDYIY DKDIEIIAKE EQRKAWKMQG VGEKFSTWEP
160 170 180 190 200
TKRELELLKH NPKRRKITSN CTIGLRGLIN LGNTCFMNCI VQALTHTPLL
210 220 230 240 250
RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI PYKLLHLVWT
260 270 280 290 300
HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI
310 320 330 340 350
FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGSVV
360 370 380 390 400
NGESHASGTT TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK
410 420 430 440 450
LPIVACFHLK RFEHSAKLRR KITTYVSFPL ELDMTPFMAS SKESRMNGQY
460 470 480 490 500
QQPLDSLNND NKYSLFAVVN HQGTLESGHY TSFIRQHKDQ WFKCDDAIIT
510 520
KASIKDVLDS EGYLLFYHKQ FLEYE
Length:525
Mass (Da):59,954
Last modified:September 13, 2005 - v2
Checksum:iC4CD69A0317CD0EF
GO

Sequence cautioni

The sequence BAD90248.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771L → H in BAE36137. (PubMed:16141072)Curated
Sequence conflicti188 – 1881N → D in AAH80737. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK084022 mRNA. Translation: BAC39100.1.
AK220368 mRNA. Translation: BAD90248.1. Different initiation.
AK155071 mRNA. Translation: BAE33026.1.
AK160992 mRNA. Translation: BAE36137.1.
AL646093 Genomic DNA. Translation: CAI25897.1.
BC058419 mRNA. Translation: AAH58419.1.
BC080737 mRNA. Translation: AAH80737.1.
CCDSiCCDS24807.1.
RefSeqiNP_001004143.2. NM_001004143.4.
UniGeneiMm.30602.

Genome annotation databases

EnsembliENSMUST00000041683; ENSMUSP00000041263; ENSMUSG00000042506.
GeneIDi216825.
KEGGimmu:216825.
UCSCiuc007jhc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK084022 mRNA. Translation: BAC39100.1 .
AK220368 mRNA. Translation: BAD90248.1 . Different initiation.
AK155071 mRNA. Translation: BAE33026.1 .
AK160992 mRNA. Translation: BAE36137.1 .
AL646093 Genomic DNA. Translation: CAI25897.1 .
BC058419 mRNA. Translation: AAH58419.1 .
BC080737 mRNA. Translation: AAH80737.1 .
CCDSi CCDS24807.1.
RefSeqi NP_001004143.2. NM_001004143.4.
UniGenei Mm.30602.

3D structure databases

ProteinModelPortali Q5DU02.
SMRi Q5DU02. Positions 76-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5DU02. 2 interactions.

Protein family/group databases

MEROPSi C19.035.

PTM databases

PhosphoSitei Q5DU02.

Proteomic databases

MaxQBi Q5DU02.
PaxDbi Q5DU02.
PRIDEi Q5DU02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041683 ; ENSMUSP00000041263 ; ENSMUSG00000042506 .
GeneIDi 216825.
KEGGi mmu:216825.
UCSCi uc007jhc.2. mouse.

Organism-specific databases

CTDi 23326.
MGIi MGI:2144157. Usp22.
Rougei Search...

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00760000119203.
HOVERGENi HBG058014.
InParanoidi Q5DU02.
KOi K11366.
OMAi YCQMCDD.
OrthoDBi EOG7FR7G7.
PhylomeDBi Q5DU02.
TreeFami TF323554.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

NextBioi 375358.
PROi Q5DU02.
SOURCEi Search...

Gene expression databases

Bgeei Q5DU02.
CleanExi MM_USP22.
ExpressionAtlasi Q5DU02. baseline and differential.
Genevestigatori Q5DU02.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head and Spinal ganglion.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. "The expression patterns of deubiquitinating enzymes, USP22 and Usp22."
    Lee H.-J., Kim M.-S., Shin J.-M., Park T.-J., Chung H.-M., Baek K.-H.
    Gene Expr. Patterns 6:277-284(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiUBP22_MOUSE
AccessioniPrimary (citable) accession number: Q5DU02
Secondary accession number(s): Q3TU34
, Q3U2W4, Q5SU81, Q66JV8, Q6PDX3, Q8BJG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3