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Q5DU02

- UBP22_MOUSE

UniProt

Q5DU02 - UBP22_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 22

Gene

Usp22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851NucleophilePROSITE-ProRule annotation
    Active sitei479 – 4791Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri61 – 12161UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: Ensembl
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    3. ubiquitin-specific protease activity Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. histone deubiquitination Source: Ensembl
    3. histone ubiquitination Source: Ensembl
    4. positive regulation of mitotic cell cycle Source: Ensembl
    5. positive regulation of transcription, DNA-templated Source: Ensembl
    6. protein deubiquitination Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW
    8. ubiquitin-dependent protein catabolic process Source: MGI

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Protein family/group databases

    MEROPSiC19.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 22 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 22
    Ubiquitin thioesterase 22
    Ubiquitin-specific-processing protease 22
    Gene namesi
    Name:Usp22
    Synonyms:Kiaa1063
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2144157. Usp22.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. SAGA complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Ubiquitin carboxyl-terminal hydrolase 22PRO_0000080651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5DU02.
    PRIDEiQ5DU02.

    PTM databases

    PhosphoSiteiQ5DU02.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and weakly in other organs.1 Publication

    Developmental stagei

    Highly expressed between E10.5 and E12.5. Expressed in the midbrain, forebrain, hindbrain and dorsal root ganglia of embryos at E12.5.1 Publication

    Gene expression databases

    BgeeiQ5DU02.
    CleanExiMM_USP22.
    GenevestigatoriQ5DU02.

    Interactioni

    Subunit structurei

    Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ5DU02. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5DU02.
    SMRiQ5DU02. Positions 76-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 520345USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. UBP8 subfamily.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri61 – 12161UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117288.
    HOVERGENiHBG058014.
    InParanoidiQ3U2W4.
    KOiK11366.
    OMAiYCQMCDD.
    OrthoDBiEOG7FR7G7.
    PhylomeDBiQ5DU02.
    TreeFamiTF323554.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5DU02-1 [UniParc]FASTAAdd to Basket

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    MVARPEPEVE AMDAELAVPP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT    50
    AEARKRKAKS CVCHVCGIHL NRLHSCLYCV FFGCFTKKHI HDHAKSKRHN 100
    LAIDLMYGGI YCFLCQDYIY DKDIEIIAKE EQRKAWKMQG VGEKFSTWEP 150
    TKRELELLKH NPKRRKITSN CTIGLRGLIN LGNTCFMNCI VQALTHTPLL 200
    RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI PYKLLHLVWT 250
    HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI 300
    FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGSVV 350
    NGESHASGTT TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK 400
    LPIVACFHLK RFEHSAKLRR KITTYVSFPL ELDMTPFMAS SKESRMNGQY 450
    QQPLDSLNND NKYSLFAVVN HQGTLESGHY TSFIRQHKDQ WFKCDDAIIT 500
    KASIKDVLDS EGYLLFYHKQ FLEYE 525
    Length:525
    Mass (Da):59,954
    Last modified:September 13, 2005 - v2
    Checksum:iC4CD69A0317CD0EF
    GO

    Sequence cautioni

    The sequence BAD90248.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771L → H in BAE36137. (PubMed:16141072)Curated
    Sequence conflicti188 – 1881N → D in AAH80737. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084022 mRNA. Translation: BAC39100.1.
    AK220368 mRNA. Translation: BAD90248.1. Different initiation.
    AK155071 mRNA. Translation: BAE33026.1.
    AK160992 mRNA. Translation: BAE36137.1.
    AL646093 Genomic DNA. Translation: CAI25897.1.
    BC058419 mRNA. Translation: AAH58419.1.
    BC080737 mRNA. Translation: AAH80737.1.
    CCDSiCCDS24807.1.
    RefSeqiNP_001004143.2. NM_001004143.4.
    UniGeneiMm.30602.

    Genome annotation databases

    EnsembliENSMUST00000041683; ENSMUSP00000041263; ENSMUSG00000042506.
    GeneIDi216825.
    KEGGimmu:216825.
    UCSCiuc007jhc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084022 mRNA. Translation: BAC39100.1 .
    AK220368 mRNA. Translation: BAD90248.1 . Different initiation.
    AK155071 mRNA. Translation: BAE33026.1 .
    AK160992 mRNA. Translation: BAE36137.1 .
    AL646093 Genomic DNA. Translation: CAI25897.1 .
    BC058419 mRNA. Translation: AAH58419.1 .
    BC080737 mRNA. Translation: AAH80737.1 .
    CCDSi CCDS24807.1.
    RefSeqi NP_001004143.2. NM_001004143.4.
    UniGenei Mm.30602.

    3D structure databases

    ProteinModelPortali Q5DU02.
    SMRi Q5DU02. Positions 76-517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5DU02. 2 interactions.

    Protein family/group databases

    MEROPSi C19.035.

    PTM databases

    PhosphoSitei Q5DU02.

    Proteomic databases

    PaxDbi Q5DU02.
    PRIDEi Q5DU02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041683 ; ENSMUSP00000041263 ; ENSMUSG00000042506 .
    GeneIDi 216825.
    KEGGi mmu:216825.
    UCSCi uc007jhc.2. mouse.

    Organism-specific databases

    CTDi 23326.
    MGIi MGI:2144157. Usp22.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117288.
    HOVERGENi HBG058014.
    InParanoidi Q3U2W4.
    KOi K11366.
    OMAi YCQMCDD.
    OrthoDBi EOG7FR7G7.
    PhylomeDBi Q5DU02.
    TreeFami TF323554.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 375358.
    PROi Q5DU02.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5DU02.
    CleanExi MM_USP22.
    Genevestigatori Q5DU02.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head and Spinal ganglion.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    5. "The expression patterns of deubiquitinating enzymes, USP22 and Usp22."
      Lee H.-J., Kim M.-S., Shin J.-M., Park T.-J., Chung H.-M., Baek K.-H.
      Gene Expr. Patterns 6:277-284(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiUBP22_MOUSE
    AccessioniPrimary (citable) accession number: Q5DU02
    Secondary accession number(s): Q3TU34
    , Q3U2W4, Q5SU81, Q66JV8, Q6PDX3, Q8BJG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3