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Protein

Doublecortin domain-containing protein 2

Gene

Dcdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length (By similarity).By similarity

GO - Biological processi

  • dendrite morphogenesis Source: MGI
  • intracellular signal transduction Source: InterPro
  • neuron migration Source: UniProtKB
  • positive regulation of smoothened signaling pathway Source: MGI
  • regulation of cilium assembly Source: UniProtKB
  • regulation of Wnt signaling pathway Source: UniProtKB
  • sensory perception of sound Source: UniProtKB
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2
Gene namesi
Name:Dcdc2
Synonyms:Dcdc2a, Kiaa1154
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2652818. Dcdc2a.

Subcellular locationi

  • Cell projectioncilium
  • Cytoplasmcytoskeletoncilium axoneme By similarity
  • Cell projectionkinocilium By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Animals develop periportal hepatic fibrosis with biliary duct proliferation at age 11 months.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Doublecortin domain-containing protein 2PRO_0000079805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5DU00.
PaxDbiQ5DU00.
PRIDEiQ5DU00.

PTM databases

PhosphoSiteiQ5DU00.

Expressioni

Tissue specificityi

Expressed in hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiQ5DU00.
CleanExiMM_DCDC2A.
ExpressionAtlasiQ5DU00. baseline and differential.

Interactioni

Subunit structurei

Interacts with DVL1, DVL2 and DVL3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063650.

Structurei

3D structure databases

ProteinModelPortaliQ5DU00.
SMRiQ5DU00. Positions 17-99, 132-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 10084Doublecortin 1PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 22183Doublecortin 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00510000046928.
HOGENOMiHOG000082435.
HOVERGENiHBG051319.
InParanoidiQ5DU00.
OrthoDBiEOG78D7K5.
PhylomeDBiQ5DU00.
TreeFamiTF338406.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR033036. DCDC2.
IPR003533. Doublecortin_dom.
[Graphical view]
PANTHERiPTHR23004:SF5. PTHR23004:SF5. 1 hit.
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DU00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGPSSRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDVFLKE
60 70 80 90 100
VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG PEAFKKLNYL
110 120 130 140 150
DIGEIKKRPM EAVNTEVKPV IHSRINVSAR FRKSLHEPCT IFLIANGDLI
160 170 180 190 200
SPASRLLIPK KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE
210 220 230 240 250
LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS
260 270 280 290 300
KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKTSH
310 320 330 340 350
QAIPDNGEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE
360 370 380 390 400
DGEKTSKDAN QKEDFSAMNG ETEDRGGSKA AGTSEQEEGI PDHGEKKSSP
410 420 430 440 450
SRVNGGTDEE NGEELDQVAE ELQPTEDEKG KAEGDNSGQD EAGLDAQRPP
460 470
RPEVTVTSPQ ENEENEANKA SSAVA
Length:475
Mass (Da):51,953
Last modified:July 19, 2005 - v2
Checksum:iB4195FC005B62F4A
GO
Isoform 2 (identifier: Q5DU00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-368: EGIFKAGAER...ANQKEDFSAM → WLIKVERDTC...KAQPTYGHSM
     369-475: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):41,265
Checksum:i70C563125707206C
GO

Sequence cautioni

The sequence BAD90429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti398 – 3981S → A in CAI24561 (PubMed:19468303).Curated
Sequence conflicti424 – 4241P → S in CAI24561 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei308 – 36861EGIFK…DFSAM → WLIKVERDTCLRPQLDGNRN RVTALPPYPWSIHTRHMWDA PGEDRWKKVTNKAQPTYGHS M in isoform 2. 1 PublicationVSP_014672Add
BLAST
Alternative sequencei369 – 475107Missing in isoform 2. 1 PublicationVSP_014673Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220370 mRNA. Translation: BAD90429.1. Different initiation.
AL589735 Genomic DNA. Translation: CAI24561.1.
BC045136 mRNA. Translation: AAH45136.1.
CCDSiCCDS26386.2. [Q5DU00-1]
CCDS56873.1. [Q5DU00-2]
RefSeqiNP_001182546.1. NM_001195617.1. [Q5DU00-2]
NP_808245.2. NM_177577.3.
UniGeneiMm.284719.

Genome annotation databases

EnsembliENSMUST00000036932; ENSMUSP00000047641; ENSMUSG00000035910. [Q5DU00-2]
GeneIDi195208.
KEGGimmu:195208.
UCSCiuc007pwv.1. mouse. [Q5DU00-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220370 mRNA. Translation: BAD90429.1. Different initiation.
AL589735 Genomic DNA. Translation: CAI24561.1.
BC045136 mRNA. Translation: AAH45136.1.
CCDSiCCDS26386.2. [Q5DU00-1]
CCDS56873.1. [Q5DU00-2]
RefSeqiNP_001182546.1. NM_001195617.1. [Q5DU00-2]
NP_808245.2. NM_177577.3.
UniGeneiMm.284719.

3D structure databases

ProteinModelPortaliQ5DU00.
SMRiQ5DU00. Positions 17-99, 132-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063650.

PTM databases

PhosphoSiteiQ5DU00.

Proteomic databases

MaxQBiQ5DU00.
PaxDbiQ5DU00.
PRIDEiQ5DU00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036932; ENSMUSP00000047641; ENSMUSG00000035910. [Q5DU00-2]
GeneIDi195208.
KEGGimmu:195208.
UCSCiuc007pwv.1. mouse. [Q5DU00-2]

Organism-specific databases

CTDi195208.
MGIiMGI:2652818. Dcdc2a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00510000046928.
HOGENOMiHOG000082435.
HOVERGENiHBG051319.
InParanoidiQ5DU00.
OrthoDBiEOG78D7K5.
PhylomeDBiQ5DU00.
TreeFamiTF338406.

Miscellaneous databases

NextBioi371711.
PROiQ5DU00.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DU00.
CleanExiMM_DCDC2A.
ExpressionAtlasiQ5DU00. baseline and differential.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR033036. DCDC2.
IPR003533. Doublecortin_dom.
[Graphical view]
PANTHERiPTHR23004:SF5. PTHR23004:SF5. 1 hit.
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Olfactory epithelium.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.
  5. Cited for: DISRUPTION PHENOTYPE.
  6. "A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation."
    Grati M., Chakchouk I., Ma Q., Bensaid M., Desmidt A., Turki N., Yan D., Baanannou A., Mittal R., Driss N., Blanton S., Farooq A., Lu Z., Liu X.Z., Masmoudi S.
    Hum. Mol. Genet. 24:2482-2491(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDCDC2_MOUSE
AccessioniPrimary (citable) accession number: Q5DU00
Secondary accession number(s): Q5SZU0, Q80Y99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 16, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.