Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD16

Gene

Kctd16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD16
Gene namesi
Name:Kctd16
Synonyms:Gm1267, Kiaa1317
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914659. Kctd16.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: MGI
  • presynaptic membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002485941 – 427BTB/POZ domain-containing protein KCTD16Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphotyrosineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5DTY9.
PaxDbiQ5DTY9.
PeptideAtlasiQ5DTY9.
PRIDEiQ5DTY9.

PTM databases

iPTMnetiQ5DTY9.
PhosphoSitePlusiQ5DTY9.

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000051401.
GenevisibleiQ5DTY9. MM.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.1 Publication

Protein-protein interaction databases

BioGridi238715. 1 interactor.
IntActiQ5DTY9. 1 interactor.
STRINGi10090.ENSMUSP00000089547.

Structurei

3D structure databases

ProteinModelPortaliQ5DTY9.
SMRiQ5DTY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98BTBAdd BLAST74

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ5DTY9.
OMAiVPRILIC.
OrthoDBiEOG091G0P3F.
PhylomeDBiQ5DTY9.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5DTY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGNCSRY YPRDQGAAVP NSFPEVIELN VGGQVYFTRH STLISIPHSL
60 70 80 90 100
LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF
110 120 130 140 150
PERGRLKREA EYFQLPDLVK LLAPEDVKQS PDEFCHSDFE DASQGSDTRI
160 170 180 190 200
CPPSSLLPHD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL
210 220 230 240 250
AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC
260 270 280 290 300
NSSVTASFVN QYTEDKIWSS YTEYVFYREP SRWSSSHCDC CCKNGKGDKG
310 320 330 340 350
ESGTSCNDLS TSSCDSQSEA SSPQETVICG PVTRQSNIQT LDRPIKKGPV
360 370 380 390 400
QLIQQSEMRR KSDLLRTLTS GSRESNISSK KKAAKEKLSI EEELEKCIQD
410 420
FLKIKIPDRF PERKHPWQSE LLRKYHL
Length:427
Mass (Da):48,972
Last modified:September 5, 2006 - v2
Checksum:iC19AFA955BD30585
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317Q → E in BAB24283 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098707 Genomic DNA. No translation available.
AC127249 Genomic DNA. No translation available.
AK220381 mRNA. Translation: BAD90438.1.
AK005863 mRNA. Translation: BAB24283.1.
CCDSiCCDS50264.1.
RefSeqiNP_080411.1. NM_026135.1.
XP_017173425.1. XM_017317936.1.
XP_017173426.1. XM_017317937.1.
XP_017173427.1. XM_017317938.1.
XP_017173428.1. XM_017317939.1.
UniGeneiMm.76366.

Genome annotation databases

EnsembliENSMUST00000091927; ENSMUSP00000089547; ENSMUSG00000051401.
GeneIDi383348.
KEGGimmu:383348.
UCSCiuc012bch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098707 Genomic DNA. No translation available.
AC127249 Genomic DNA. No translation available.
AK220381 mRNA. Translation: BAD90438.1.
AK005863 mRNA. Translation: BAB24283.1.
CCDSiCCDS50264.1.
RefSeqiNP_080411.1. NM_026135.1.
XP_017173425.1. XM_017317936.1.
XP_017173426.1. XM_017317937.1.
XP_017173427.1. XM_017317938.1.
XP_017173428.1. XM_017317939.1.
UniGeneiMm.76366.

3D structure databases

ProteinModelPortaliQ5DTY9.
SMRiQ5DTY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238715. 1 interactor.
IntActiQ5DTY9. 1 interactor.
STRINGi10090.ENSMUSP00000089547.

PTM databases

iPTMnetiQ5DTY9.
PhosphoSitePlusiQ5DTY9.

Proteomic databases

MaxQBiQ5DTY9.
PaxDbiQ5DTY9.
PeptideAtlasiQ5DTY9.
PRIDEiQ5DTY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091927; ENSMUSP00000089547; ENSMUSG00000051401.
GeneIDi383348.
KEGGimmu:383348.
UCSCiuc012bch.1. mouse.

Organism-specific databases

CTDi57528.
MGIiMGI:1914659. Kctd16.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ5DTY9.
OMAiVPRILIC.
OrthoDBiEOG091G0P3F.
PhylomeDBiQ5DTY9.
TreeFamiTF315332.

Miscellaneous databases

PROiQ5DTY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051401.
GenevisibleiQ5DTY9. MM.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD16_MOUSE
AccessioniPrimary (citable) accession number: Q5DTY9
Secondary accession number(s): Q78Y50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.