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Protein

BTB/POZ domain-containing protein KCTD16

Gene

Kctd16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD16
Gene namesi
Name:Kctd16
Synonyms:Gm1267, Kiaa1317
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914659. Kctd16.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: MGI
  • presynaptic membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427BTB/POZ domain-containing protein KCTD16PRO_0000248594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121PhosphotyrosineCombined sources
Modified residuei130 – 1301PhosphoserineCombined sources
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei146 – 1461PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5DTY9.
MaxQBiQ5DTY9.
PaxDbiQ5DTY9.
PeptideAtlasiQ5DTY9.
PRIDEiQ5DTY9.

PTM databases

iPTMnetiQ5DTY9.
PhosphoSiteiQ5DTY9.

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the hippocampus.1 Publication

Gene expression databases

BgeeiQ5DTY9.
GenevisibleiQ5DTY9. MM.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.1 Publication

Protein-protein interaction databases

BioGridi238715. 1 interaction.
IntActiQ5DTY9. 1 interaction.
STRINGi10090.ENSMUSP00000089547.

Structurei

3D structure databases

ProteinModelPortaliQ5DTY9.
SMRiQ5DTY9. Positions 27-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9874BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ5DTY9.
OMAiVPRILIC.
OrthoDBiEOG7K3TM1.
PhylomeDBiQ5DTY9.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5DTY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGNCSRY YPRDQGAAVP NSFPEVIELN VGGQVYFTRH STLISIPHSL
60 70 80 90 100
LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF
110 120 130 140 150
PERGRLKREA EYFQLPDLVK LLAPEDVKQS PDEFCHSDFE DASQGSDTRI
160 170 180 190 200
CPPSSLLPHD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL
210 220 230 240 250
AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC
260 270 280 290 300
NSSVTASFVN QYTEDKIWSS YTEYVFYREP SRWSSSHCDC CCKNGKGDKG
310 320 330 340 350
ESGTSCNDLS TSSCDSQSEA SSPQETVICG PVTRQSNIQT LDRPIKKGPV
360 370 380 390 400
QLIQQSEMRR KSDLLRTLTS GSRESNISSK KKAAKEKLSI EEELEKCIQD
410 420
FLKIKIPDRF PERKHPWQSE LLRKYHL
Length:427
Mass (Da):48,972
Last modified:September 5, 2006 - v2
Checksum:iC19AFA955BD30585
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171Q → E in BAB24283 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098707 Genomic DNA. No translation available.
AC127249 Genomic DNA. No translation available.
AK220381 mRNA. Translation: BAD90438.1.
AK005863 mRNA. Translation: BAB24283.1.
CCDSiCCDS50264.1.
RefSeqiNP_080411.1. NM_026135.1.
UniGeneiMm.76366.

Genome annotation databases

EnsembliENSMUST00000091927; ENSMUSP00000089547; ENSMUSG00000051401.
GeneIDi383348.
KEGGimmu:383348.
UCSCiuc012bch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098707 Genomic DNA. No translation available.
AC127249 Genomic DNA. No translation available.
AK220381 mRNA. Translation: BAD90438.1.
AK005863 mRNA. Translation: BAB24283.1.
CCDSiCCDS50264.1.
RefSeqiNP_080411.1. NM_026135.1.
UniGeneiMm.76366.

3D structure databases

ProteinModelPortaliQ5DTY9.
SMRiQ5DTY9. Positions 27-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238715. 1 interaction.
IntActiQ5DTY9. 1 interaction.
STRINGi10090.ENSMUSP00000089547.

PTM databases

iPTMnetiQ5DTY9.
PhosphoSiteiQ5DTY9.

Proteomic databases

EPDiQ5DTY9.
MaxQBiQ5DTY9.
PaxDbiQ5DTY9.
PeptideAtlasiQ5DTY9.
PRIDEiQ5DTY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091927; ENSMUSP00000089547; ENSMUSG00000051401.
GeneIDi383348.
KEGGimmu:383348.
UCSCiuc012bch.1. mouse.

Organism-specific databases

CTDi57528.
MGIiMGI:1914659. Kctd16.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ5DTY9.
OMAiVPRILIC.
OrthoDBiEOG7K3TM1.
PhylomeDBiQ5DTY9.
TreeFamiTF315332.

Miscellaneous databases

PROiQ5DTY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DTY9.
GenevisibleiQ5DTY9. MM.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-427.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 317-427.
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-137; SER-143 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: FUNCTION, INTERACTION WITH GABRB1 AND GABRB2, TETRAMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCD16_MOUSE
AccessioniPrimary (citable) accession number: Q5DTY9
Secondary accession number(s): Q78Y50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 6, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.