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Protein

BTB/POZ domain-containing protein KCTD16

Gene

Kctd16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD16
Gene namesi
Name:Kctd16
Synonyms:Gm1267, Kiaa1317
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1914659 Kctd16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002485941 – 427BTB/POZ domain-containing protein KCTD16Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphotyrosineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5DTY9
PaxDbiQ5DTY9
PeptideAtlasiQ5DTY9
PRIDEiQ5DTY9

PTM databases

iPTMnetiQ5DTY9
PhosphoSitePlusiQ5DTY9

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000051401
GenevisibleiQ5DTY9 MM

Interactioni

Subunit structurei

Homopentamer; forms an open pentamer (By similarity). In contrast to other BTB domain-containing proteins, does not interact with CUL3 (By similarity). Interacts as a tetramer with GABRB1 and GABRB2 (PubMed:20400944).By similarity1 Publication

Protein-protein interaction databases

BioGridi238715, 4 interactors
CORUMiQ5DTY9
IntActiQ5DTY9, 4 interactors
STRINGi10090.ENSMUSP00000089547

Structurei

3D structure databases

ProteinModelPortaliQ5DTY9
SMRiQ5DTY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98BTBAdd BLAST74

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ5DTY9
KOiK21918
OMAiSECGFQM
OrthoDBiEOG091G0P3F
PhylomeDBiQ5DTY9
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q5DTY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGNCSRY YPRDQGAAVP NSFPEVIELN VGGQVYFTRH STLISIPHSL
60 70 80 90 100
LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF
110 120 130 140 150
PERGRLKREA EYFQLPDLVK LLAPEDVKQS PDEFCHSDFE DASQGSDTRI
160 170 180 190 200
CPPSSLLPHD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL
210 220 230 240 250
AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC
260 270 280 290 300
NSSVTASFVN QYTEDKIWSS YTEYVFYREP SRWSSSHCDC CCKNGKGDKG
310 320 330 340 350
ESGTSCNDLS TSSCDSQSEA SSPQETVICG PVTRQSNIQT LDRPIKKGPV
360 370 380 390 400
QLIQQSEMRR KSDLLRTLTS GSRESNISSK KKAAKEKLSI EEELEKCIQD
410 420
FLKIKIPDRF PERKHPWQSE LLRKYHL
Length:427
Mass (Da):48,972
Last modified:September 5, 2006 - v2
Checksum:iC19AFA955BD30585
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317Q → E in BAB24283 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098707 Genomic DNA No translation available.
AC127249 Genomic DNA No translation available.
AK220381 mRNA Translation: BAD90438.1
AK005863 mRNA Translation: BAB24283.1
CCDSiCCDS50264.1
RefSeqiNP_080411.1, NM_026135.1
XP_017173425.1, XM_017317936.1
XP_017173426.1, XM_017317937.1
XP_017173427.1, XM_017317938.1
XP_017173428.1, XM_017317939.1
UniGeneiMm.76366

Genome annotation databases

EnsembliENSMUST00000091927; ENSMUSP00000089547; ENSMUSG00000051401
GeneIDi383348
KEGGimmu:383348
UCSCiuc012bch.1 mouse

Entry informationi

Entry nameiKCD16_MOUSE
AccessioniPrimary (citable) accession number: Q5DTY9
Secondary accession number(s): Q78Y50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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