Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium-driven chloride bicarbonate exchanger

Gene

Slc4a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH.1 Publication

GO - Molecular functioni

GO - Biological processi

  • brain morphogenesis Source: MGI
  • locomotory exploration behavior Source: MGI
  • multicellular organism growth Source: MGI
  • post-embryonic development Source: MGI
  • protein glycosylation Source: MGI
  • proton transmembrane transport Source: MGI
  • pyramidal neuron development Source: MGI
  • regulation of cellular pH Source: MGI
  • regulation of intracellular pH Source: GO_Central
  • regulation of pH Source: MGI
  • response to light stimulus Source: MGI

Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-425381 Bicarbonate transporters

Protein family/group databases

TCDBi2.A.31.2.3 the anion exchanger (ae) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:Slc4a10
Synonyms:Kiaa4136, Ncbe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2150150 Slc4a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 509CytoplasmicSequence analysisAdd BLAST509
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 538ExtracellularSequence analysis8
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 562CytoplasmicSequence analysis3
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 596ExtracellularSequence analysisAdd BLAST13
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 626CytoplasmicSequence analysis9
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 720ExtracellularSequence analysisAdd BLAST73
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21
Topological domaini742 – 762CytoplasmicSequence analysisAdd BLAST21
Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Topological domaini784 – 809ExtracellularSequence analysisAdd BLAST26
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21
Topological domaini831 – 855CytoplasmicSequence analysisAdd BLAST25
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 912ExtracellularSequence analysisAdd BLAST36
Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Topological domaini934 – 935CytoplasmicSequence analysis2
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 998ExtracellularSequence analysisAdd BLAST42
Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21
Topological domaini1020 – 1118CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452411 – 1118Sodium-driven chloride bicarbonate exchangerAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineCombined sources1
Modified residuei94PhosphothreonineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1085PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DTL9
PRIDEiQ5DTL9

PTM databases

iPTMnetiQ5DTL9
PhosphoSitePlusiQ5DTL9

Expressioni

Tissue specificityi

Expressed in pancreatic islets and in the brain, in the epithelial cells of the choroid plexus.2 Publications

Gene expression databases

BgeeiENSMUSG00000026904
ExpressionAtlasiQ5DTL9 baseline and differential
GenevisibleiQ5DTL9 MM

Interactioni

Protein-protein interaction databases

IntActiQ5DTL9, 1 interactor
STRINGi10090.ENSMUSP00000108099

Structurei

3D structure databases

ProteinModelPortaliQ5DTL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000280684
HOVERGENiHBG004326
InParanoidiQ5DTL9
KOiK13861
OMAiFTVIQMS
OrthoDBiEOG091G01FT
PhylomeDBiQ5DTL9
TreeFamiTF313630

Family and domain databases

InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 2 hits
TIGRFAMsiTIGR00834 ae, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DTL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHLPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTIEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLA NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNAGQVV SPQSAPACAE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
310 320 330 340 350
MKQRLDKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
360 370 380 390 400
RLSPAVLLQG LAEVPIPSRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
410 420 430 440 450
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
460 470 480 490 500
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPFFWSD
510 520 530 540 550
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
560 570 580 590 600
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
610 620 630 640 650
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSET
660 670 680 690 700
YPINMHNDLE LLTQYSCNCM EPHSPSNDTL KEWRESNLSA SDIIWGNLTV
710 720 730 740 750
SECRSLHGEY VGRACGHGHP YVPDVLFWSV ILFFSTVTMS ATLKQFKTSR
760 770 780 790 800
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
810 820 830 840 850
WFVTPLGPNP WWTIIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
860 870 880 890 900
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
910 920 930 940 950
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
960 970 980 990 1000
KGIQLFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTVIQ MSCLGLLWII
1010 1020 1030 1040 1050
KVSRAAIVFP MMVLALVFVR KLMDFLFTKR ELSWLDDLMP ESKKKKLEDA
1060 1070 1080 1090 1100
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TAMWGNLLVT
1110
ADNSKEKESR FPSKSSPS
Length:1,118
Mass (Da):125,817
Last modified:July 11, 2006 - v2
Checksum:i85E3110C976978A7
GO
Isoform 2 (identifier: Q5DTL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Show »
Length:1,088
Mass (Da):122,550
Checksum:iC06FCBC60D21959F
GO

Sequence cautioni

The sequence BAD90511 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239F → L in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti256Missing in AAH39226 (PubMed:15489334).Curated1
Sequence conflicti345T → A in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti487I → M in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti796 – 797RD → IY in BAB17922 (PubMed:10993873).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019654287 – 316Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033759 mRNA Translation: BAB17922.1
AK220501 mRNA Translation: BAD90511.1 Different initiation.
BC039226 mRNA Translation: AAH39226.1
CCDSiCCDS16064.1 [Q5DTL9-2]
CCDS57172.1 [Q5DTL9-1]
RefSeqiNP_001229309.1, NM_001242380.1 [Q5DTL9-1]
NP_001229310.1, NM_001242381.1
UniGeneiMm.314497

Genome annotation databases

EnsembliENSMUST00000102735; ENSMUSP00000099796; ENSMUSG00000026904 [Q5DTL9-2]
ENSMUST00000112480; ENSMUSP00000108099; ENSMUSG00000026904 [Q5DTL9-1]
GeneIDi94229
KEGGimmu:94229
UCSCiuc008jve.3 mouse [Q5DTL9-2]
uc008jvf.3 mouse [Q5DTL9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS4A10_MOUSE
AccessioniPrimary (citable) accession number: Q5DTL9
Secondary accession number(s): Q8CFS3, Q9EST0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: April 25, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health