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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

Slc4a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH.1 Publication

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • brain morphogenesis Source: MGI
  • hydrogen ion transmembrane transport Source: MGI
  • locomotory exploration behavior Source: MGI
  • multicellular organism growth Source: MGI
  • post-embryonic development Source: MGI
  • protein glycosylation Source: MGI
  • pyramidal neuron development Source: MGI
  • regulation of cellular pH Source: MGI
  • regulation of intracellular pH Source: GO_Central
  • regulation of pH Source: MGI
  • response to light stimulus Source: MGI
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425381. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.2.3. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:Slc4a10
Synonyms:Kiaa4136, Ncbe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2150150. Slc4a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 509509CytoplasmicSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST
Topological domaini531 – 5388ExtracellularSequence analysis
Transmembranei539 – 55921HelicalSequence analysisAdd
BLAST
Topological domaini560 – 5623CytoplasmicSequence analysis
Transmembranei563 – 58321HelicalSequence analysisAdd
BLAST
Topological domaini584 – 59613ExtracellularSequence analysisAdd
BLAST
Transmembranei597 – 61721HelicalSequence analysisAdd
BLAST
Topological domaini618 – 6269CytoplasmicSequence analysis
Transmembranei627 – 64721HelicalSequence analysisAdd
BLAST
Topological domaini648 – 72073ExtracellularSequence analysisAdd
BLAST
Transmembranei721 – 74121HelicalSequence analysisAdd
BLAST
Topological domaini742 – 76221CytoplasmicSequence analysisAdd
BLAST
Transmembranei763 – 78321HelicalSequence analysisAdd
BLAST
Topological domaini784 – 80926ExtracellularSequence analysisAdd
BLAST
Transmembranei810 – 83021HelicalSequence analysisAdd
BLAST
Topological domaini831 – 85525CytoplasmicSequence analysisAdd
BLAST
Transmembranei856 – 87621HelicalSequence analysisAdd
BLAST
Topological domaini877 – 91236ExtracellularSequence analysisAdd
BLAST
Transmembranei913 – 93321HelicalSequence analysisAdd
BLAST
Topological domaini934 – 9352CytoplasmicSequence analysis
Transmembranei936 – 95621HelicalSequence analysisAdd
BLAST
Topological domaini957 – 99842ExtracellularSequence analysisAdd
BLAST
Transmembranei999 – 101921HelicalSequence analysisAdd
BLAST
Topological domaini1020 – 111899CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical dendrite Source: MGI
  • basilar dendrite Source: MGI
  • basolateral plasma membrane Source: MGI
  • CA3 pyramidal cell dendrite Source: MGI
  • integral component of plasma membrane Source: MGI
  • neuronal cell body Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11181118Sodium-driven chloride bicarbonate exchangerPRO_0000245241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891PhosphoserineCombined sources
Modified residuei94 – 941PhosphothreonineCombined sources
Modified residuei276 – 2761PhosphoserineCombined sources
Modified residuei1057 – 10571PhosphoserineCombined sources
Modified residuei1085 – 10851PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5DTL9.
PaxDbiQ5DTL9.
PRIDEiQ5DTL9.

PTM databases

iPTMnetiQ5DTL9.
PhosphoSiteiQ5DTL9.

Expressioni

Tissue specificityi

Expressed in pancreatic islets and in the brain, in the epithelial cells of the choroid plexus.2 Publications

Gene expression databases

BgeeiENSMUSG00000026904.
ExpressionAtlasiQ5DTL9. baseline and differential.
GenevisibleiQ5DTL9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ5DTL9. 1 interaction.
STRINGi10090.ENSMUSP00000108099.

Structurei

3D structure databases

ProteinModelPortaliQ5DTL9.
SMRiQ5DTL9. Positions 117-429, 493-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ5DTL9.
KOiK13861.
OMAiRKAPFFW.
OrthoDBiEOG091G01FT.
PhylomeDBiQ5DTL9.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DTL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHLPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTIEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLA NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNAGQVV SPQSAPACAE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
310 320 330 340 350
MKQRLDKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
360 370 380 390 400
RLSPAVLLQG LAEVPIPSRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
410 420 430 440 450
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
460 470 480 490 500
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPFFWSD
510 520 530 540 550
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
560 570 580 590 600
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
610 620 630 640 650
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSET
660 670 680 690 700
YPINMHNDLE LLTQYSCNCM EPHSPSNDTL KEWRESNLSA SDIIWGNLTV
710 720 730 740 750
SECRSLHGEY VGRACGHGHP YVPDVLFWSV ILFFSTVTMS ATLKQFKTSR
760 770 780 790 800
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
810 820 830 840 850
WFVTPLGPNP WWTIIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
860 870 880 890 900
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
910 920 930 940 950
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
960 970 980 990 1000
KGIQLFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTVIQ MSCLGLLWII
1010 1020 1030 1040 1050
KVSRAAIVFP MMVLALVFVR KLMDFLFTKR ELSWLDDLMP ESKKKKLEDA
1060 1070 1080 1090 1100
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TAMWGNLLVT
1110
ADNSKEKESR FPSKSSPS
Length:1,118
Mass (Da):125,817
Last modified:July 11, 2006 - v2
Checksum:i85E3110C976978A7
GO
Isoform 2 (identifier: Q5DTL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Show »
Length:1,088
Mass (Da):122,550
Checksum:iC06FCBC60D21959F
GO

Sequence cautioni

The sequence BAD90511 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391F → L in BAB17922 (PubMed:10993873).Curated
Sequence conflicti256 – 2561Missing in AAH39226 (PubMed:15489334).Curated
Sequence conflicti345 – 3451T → A in BAB17922 (PubMed:10993873).Curated
Sequence conflicti487 – 4871I → M in BAB17922 (PubMed:10993873).Curated
Sequence conflicti796 – 7972RD → IY in BAB17922 (PubMed:10993873).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 31630Missing in isoform 2. 2 PublicationsVSP_019654Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033759 mRNA. Translation: BAB17922.1.
AK220501 mRNA. Translation: BAD90511.1. Different initiation.
BC039226 mRNA. Translation: AAH39226.1.
CCDSiCCDS16064.1. [Q5DTL9-2]
CCDS57172.1. [Q5DTL9-1]
RefSeqiNP_001229309.1. NM_001242380.1. [Q5DTL9-1]
NP_001229310.1. NM_001242381.1.
UniGeneiMm.314497.

Genome annotation databases

EnsembliENSMUST00000102735; ENSMUSP00000099796; ENSMUSG00000026904. [Q5DTL9-2]
ENSMUST00000112480; ENSMUSP00000108099; ENSMUSG00000026904. [Q5DTL9-1]
GeneIDi94229.
KEGGimmu:94229.
UCSCiuc008jve.3. mouse. [Q5DTL9-2]
uc008jvf.3. mouse. [Q5DTL9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033759 mRNA. Translation: BAB17922.1.
AK220501 mRNA. Translation: BAD90511.1. Different initiation.
BC039226 mRNA. Translation: AAH39226.1.
CCDSiCCDS16064.1. [Q5DTL9-2]
CCDS57172.1. [Q5DTL9-1]
RefSeqiNP_001229309.1. NM_001242380.1. [Q5DTL9-1]
NP_001229310.1. NM_001242381.1.
UniGeneiMm.314497.

3D structure databases

ProteinModelPortaliQ5DTL9.
SMRiQ5DTL9. Positions 117-429, 493-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5DTL9. 1 interaction.
STRINGi10090.ENSMUSP00000108099.

Protein family/group databases

TCDBi2.A.31.2.3. the anion exchanger (ae) family.

PTM databases

iPTMnetiQ5DTL9.
PhosphoSiteiQ5DTL9.

Proteomic databases

MaxQBiQ5DTL9.
PaxDbiQ5DTL9.
PRIDEiQ5DTL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102735; ENSMUSP00000099796; ENSMUSG00000026904. [Q5DTL9-2]
ENSMUST00000112480; ENSMUSP00000108099; ENSMUSG00000026904. [Q5DTL9-1]
GeneIDi94229.
KEGGimmu:94229.
UCSCiuc008jve.3. mouse. [Q5DTL9-2]
uc008jvf.3. mouse. [Q5DTL9-1]

Organism-specific databases

CTDi57282.
MGIiMGI:2150150. Slc4a10.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ5DTL9.
KOiK13861.
OMAiRKAPFFW.
OrthoDBiEOG091G01FT.
PhylomeDBiQ5DTL9.
TreeFamiTF313630.

Enzyme and pathway databases

ReactomeiR-MMU-425381. Bicarbonate transporters.

Miscellaneous databases

PROiQ5DTL9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026904.
ExpressionAtlasiQ5DTL9. baseline and differential.
GenevisibleiQ5DTL9. MM.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS4A10_MOUSE
AccessioniPrimary (citable) accession number: Q5DTL9
Secondary accession number(s): Q8CFS3, Q9EST0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.