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Q5DTJ9

- MYPN_MOUSE

UniProt

Q5DTJ9 - MYPN_MOUSE

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Protein

Myopalladin

Gene
Mypn, Kiaa4170
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines By similarity.

GO - Biological processi

  1. sarcomere organization Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myopalladin
Gene namesi
Name:Mypn
Synonyms:Kiaa4170
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1916052. Mypn.

Subcellular locationi

Cytoplasm. Nucleus By similarity. Cytoplasmmyofibrilsarcomere
Note: Bound to sarcomere both at the Z-line periphery and in the central I-band region.

GO - Cellular componenti

  1. I band Source: BHF-UCL
  2. microtubule cytoskeleton Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
  4. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13151315MyopalladinPRO_0000240490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991Phosphoserine By similarity
Modified residuei249 – 2491Phosphothreonine By similarity
Disulfide bondi288 ↔ 339 By similarity
Disulfide bondi453 ↔ 512 By similarity
Modified residuei754 – 7541Phosphoserine By similarity
Modified residuei809 – 8091Phosphoserine By similarity
Modified residuei814 – 8141Phosphoserine By similarity
Modified residuei924 – 9241Phosphoserine By similarity
Disulfide bondi1089 ↔ 1141 By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ5DTJ9.
PaxDbiQ5DTJ9.
PRIDEiQ5DTJ9.

PTM databases

PhosphoSiteiQ5DTJ9.

Expressioni

Gene expression databases

BgeeiQ5DTJ9.
CleanExiMM_MYPN.
GenevestigatoriQ5DTJ9.

Interactioni

Subunit structurei

Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5DTJ9.
SMRiQ5DTJ9. Positions 226-531, 940-1267.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 35791Ig-like 1Add
BLAST
Domaini432 – 52897Ig-like 2Add
BLAST
Domaini941 – 102585Ig-like 3Add
BLAST
Domaini1068 – 115790Ig-like 4Add
BLAST
Domaini1167 – 125791Ig-like 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili219 – 24022 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi779 – 85274Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the myotilin/palladin family.

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG136920.
GeneTreeiENSGT00690000101977.
HOGENOMiHOG000028074.
HOVERGENiHBG059166.
InParanoidiQ5DTJ9.
OMAiQSHRGRS.
OrthoDBiEOG77WWBP.
PhylomeDBiQ5DTJ9.
TreeFamiTF343193.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5DTJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MQEDSIEAST SISQLLRESY LAETRHRGDN ERSRAEPSSN PFHFSGPGAA     50
EGGGPEDLPD LSAFLSQEEL DESVNLARLA INHDPLERVD EAQARKRLSS 100
DQTKHASKPS FEPAFHQDSS RGPASPKDSP PETKRPQYSS ETQSKKVFLN 150
KAADFIEELS SLFKAHSSKR IRPRACKNHK SKTESQNKVL QENSPTFSDL 200
TERRERASVP IPIPADSRDN ELNHAIEQRE AKRREAELAA GEAAAGDSTP 250
GSSPSSLYYE EPLGQPPRFT QKLRSREVPE GSRVQLDCIV VGIPPPQVRW 300
YCEGKELENS PDIHIVQAGN LHSLTIAEAF EEDTGRYSCF ASNIYGTDST 350
SAEIYIEGVS SSDSEGDPNK EEMNRIQKPN EVSSPPTTSA AIPPAAEAQP 400
LAAQPRVSTV QQCQSPTNYL QGLNGKPIIA APVFTKMLQN LSASEGQLVV 450
FECRVKGAPS PKVEWYREGT LIEDSPDFRI LQKKPRSMAE PEEICTLVIA 500
EVFSEDSGCF TCTASNKYGT VSSIAQLDVR GNEDISDNGA LHSANSTTNP 550
AVAEHQPSPL NPQPLSEEQP PKPKLEGVLV NHNEPRSSSR IGLRVHFNLP 600
EDDKDMEASS GSGAANTSQT RPNSFPERFN GQEARIPEPS SPIKEPPPVL 650
AKPKLDSTQL QQLHNQVLLE QQQLQNTSPS SPKESLHMSA LNSAPPAVTI 700
SSKQVKGPAP QMFNLARPKH FFPASSTSTA TVSPSSSPVF TLSNTPQTIQ 750
RTVSKESLLM AHPSTQGRSP GGLSIQNEPA PPSPAEPAAP PTAAYSIPSG 800
NQFQPHCVSP TPVSPTGRIQ NPVAFLSSVL PSLPSIPPTN AMGLPKSAPS 850
VPSQGLMKKT TKAPQAVSDD YIRETKNSVI LDLGKKVNFG DVRSHQQEYK 900
ISSFEQRLMN EIEFRLERTP VDESDDEIEH DEIPTGKCIA PIFDKRLKHF 950
RVTEGSPVTF TCKIVGIPVP KVYWFKDGKQ ISKRNEHCKM RREGDGTCSL 1000
HIESTHGDDD GNYTIMAANP QGRISCSGHL MVQGLPIRSR LSPALSHRGR 1050
SRMQERDKEP LQERFFRPHF LQAPGDMVAH EGRLCRLDCK VSGLPPPELT 1100
WLLNGQPVLP DASHKMLVRE TGVHSLLIDP LTQRDAGTYT CVATNKTGQN 1150
SFSLELTVVA KEVKKAPVIL EKLQNSGVPE GHPVRLEGRV IGMPPPVFYW 1200
KKDNETIPFT RERISMHQDT TGYVCLLIQP AKKSDAGWYT LSAKNEAGIV 1250
SCTARLDIYA QWHQQIPTPI SIRPSGSRYG SLTSKGLDIF SAFSSVESTM 1300
LYSCTSRSVV ESDEL 1315
Length:1,315
Mass (Da):144,114
Last modified:June 27, 2006 - v2
Checksum:i3CBA735F63983B3F
GO

Sequence cautioni

The sequence BAD90521.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1120 – 11201E → G in AAH52872. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220521 mRNA. Translation: BAD90521.1. Different initiation.
AK036458 mRNA. Translation: BAC29439.1.
BC052872 mRNA. Translation: AAH52872.1.
CCDSiCCDS48584.1.
RefSeqiNP_892037.2. NM_182992.2.
UniGeneiMm.259767.

Genome annotation databases

EnsembliENSMUST00000095580; ENSMUSP00000093240; ENSMUSG00000020067.
GeneIDi68802.
KEGGimmu:68802.
UCSCiuc007fjy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220521 mRNA. Translation: BAD90521.1 . Different initiation.
AK036458 mRNA. Translation: BAC29439.1 .
BC052872 mRNA. Translation: AAH52872.1 .
CCDSi CCDS48584.1.
RefSeqi NP_892037.2. NM_182992.2.
UniGenei Mm.259767.

3D structure databases

ProteinModelPortali Q5DTJ9.
SMRi Q5DTJ9. Positions 226-531, 940-1267.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5DTJ9.

Proteomic databases

MaxQBi Q5DTJ9.
PaxDbi Q5DTJ9.
PRIDEi Q5DTJ9.

Protocols and materials databases

DNASUi 68802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095580 ; ENSMUSP00000093240 ; ENSMUSG00000020067 .
GeneIDi 68802.
KEGGi mmu:68802.
UCSCi uc007fjy.2. mouse.

Organism-specific databases

CTDi 84665.
MGIi MGI:1916052. Mypn.
Rougei Search...

Phylogenomic databases

eggNOGi NOG136920.
GeneTreei ENSGT00690000101977.
HOGENOMi HOG000028074.
HOVERGENi HBG059166.
InParanoidi Q5DTJ9.
OMAi QSHRGRS.
OrthoDBi EOG77WWBP.
PhylomeDBi Q5DTJ9.
TreeFami TF343193.

Miscellaneous databases

NextBioi 327967.
PROi Q5DTJ9.
SOURCEi Search...

Gene expression databases

Bgeei Q5DTJ9.
CleanExi MM_MYPN.
Genevestigatori Q5DTJ9.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF07679. I-set. 5 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754.
    Strain: C57BL/6J.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1053-1315.
    Strain: C57BL/6J.
    Tissue: Blastocyst.

Entry informationi

Entry nameiMYPN_MOUSE
AccessioniPrimary (citable) accession number: Q5DTJ9
Secondary accession number(s): Q7TPW5, Q8BZ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi