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Q5DTJ9 (MYPN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myopalladin
Gene names
Name:Mypn
Synonyms:Kiaa4170
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines By similarity.

Subunit structure

Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity. Cytoplasmmyofibrilsarcomere. Note: Bound to sarcomere both at the Z-line periphery and in the central I-band region.

Sequence similarities

Belongs to the myotilin/palladin family.

Contains 5 Ig-like (immunoglobulin-like) domains.

Sequence caution

The sequence BAD90521.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13151315Myopalladin
PRO_0000240490

Regions

Domain267 – 35791Ig-like 1
Domain432 – 52897Ig-like 2
Domain941 – 102585Ig-like 3
Domain1068 – 115790Ig-like 4
Domain1167 – 125791Ig-like 5
Coiled coil219 – 24022 Potential
Compositional bias779 – 85274Pro-rich

Amino acid modifications

Modified residue991Phosphoserine By similarity
Modified residue2491Phosphothreonine By similarity
Modified residue7541Phosphoserine By similarity
Modified residue8091Phosphoserine By similarity
Modified residue8141Phosphoserine By similarity
Modified residue9241Phosphoserine By similarity
Disulfide bond288 ↔ 339 By similarity
Disulfide bond453 ↔ 512 By similarity
Disulfide bond1089 ↔ 1141 By similarity

Experimental info

Sequence conflict11201E → G in AAH52872. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5DTJ9 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 3CBA735F63983B3F

FASTA1,315144,114
        10         20         30         40         50         60 
MQEDSIEAST SISQLLRESY LAETRHRGDN ERSRAEPSSN PFHFSGPGAA EGGGPEDLPD 

        70         80         90        100        110        120 
LSAFLSQEEL DESVNLARLA INHDPLERVD EAQARKRLSS DQTKHASKPS FEPAFHQDSS 

       130        140        150        160        170        180 
RGPASPKDSP PETKRPQYSS ETQSKKVFLN KAADFIEELS SLFKAHSSKR IRPRACKNHK 

       190        200        210        220        230        240 
SKTESQNKVL QENSPTFSDL TERRERASVP IPIPADSRDN ELNHAIEQRE AKRREAELAA 

       250        260        270        280        290        300 
GEAAAGDSTP GSSPSSLYYE EPLGQPPRFT QKLRSREVPE GSRVQLDCIV VGIPPPQVRW 

       310        320        330        340        350        360 
YCEGKELENS PDIHIVQAGN LHSLTIAEAF EEDTGRYSCF ASNIYGTDST SAEIYIEGVS 

       370        380        390        400        410        420 
SSDSEGDPNK EEMNRIQKPN EVSSPPTTSA AIPPAAEAQP LAAQPRVSTV QQCQSPTNYL 

       430        440        450        460        470        480 
QGLNGKPIIA APVFTKMLQN LSASEGQLVV FECRVKGAPS PKVEWYREGT LIEDSPDFRI 

       490        500        510        520        530        540 
LQKKPRSMAE PEEICTLVIA EVFSEDSGCF TCTASNKYGT VSSIAQLDVR GNEDISDNGA 

       550        560        570        580        590        600 
LHSANSTTNP AVAEHQPSPL NPQPLSEEQP PKPKLEGVLV NHNEPRSSSR IGLRVHFNLP 

       610        620        630        640        650        660 
EDDKDMEASS GSGAANTSQT RPNSFPERFN GQEARIPEPS SPIKEPPPVL AKPKLDSTQL 

       670        680        690        700        710        720 
QQLHNQVLLE QQQLQNTSPS SPKESLHMSA LNSAPPAVTI SSKQVKGPAP QMFNLARPKH 

       730        740        750        760        770        780 
FFPASSTSTA TVSPSSSPVF TLSNTPQTIQ RTVSKESLLM AHPSTQGRSP GGLSIQNEPA 

       790        800        810        820        830        840 
PPSPAEPAAP PTAAYSIPSG NQFQPHCVSP TPVSPTGRIQ NPVAFLSSVL PSLPSIPPTN 

       850        860        870        880        890        900 
AMGLPKSAPS VPSQGLMKKT TKAPQAVSDD YIRETKNSVI LDLGKKVNFG DVRSHQQEYK 

       910        920        930        940        950        960 
ISSFEQRLMN EIEFRLERTP VDESDDEIEH DEIPTGKCIA PIFDKRLKHF RVTEGSPVTF 

       970        980        990       1000       1010       1020 
TCKIVGIPVP KVYWFKDGKQ ISKRNEHCKM RREGDGTCSL HIESTHGDDD GNYTIMAANP 

      1030       1040       1050       1060       1070       1080 
QGRISCSGHL MVQGLPIRSR LSPALSHRGR SRMQERDKEP LQERFFRPHF LQAPGDMVAH 

      1090       1100       1110       1120       1130       1140 
EGRLCRLDCK VSGLPPPELT WLLNGQPVLP DASHKMLVRE TGVHSLLIDP LTQRDAGTYT 

      1150       1160       1170       1180       1190       1200 
CVATNKTGQN SFSLELTVVA KEVKKAPVIL EKLQNSGVPE GHPVRLEGRV IGMPPPVFYW 

      1210       1220       1230       1240       1250       1260 
KKDNETIPFT RERISMHQDT TGYVCLLIQP AKKSDAGWYT LSAKNEAGIV SCTARLDIYA 

      1270       1280       1290       1300       1310 
QWHQQIPTPI SIRPSGSRYG SLTSKGLDIF SAFSSVESTM LYSCTSRSVV ESDEL 

« Hide

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754.
Strain: C57BL/6J.
Tissue: Bone.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1053-1315.
Strain: C57BL/6J.
Tissue: Blastocyst.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK220521 mRNA. Translation: BAD90521.1. Different initiation.
AK036458 mRNA. Translation: BAC29439.1.
BC052872 mRNA. Translation: AAH52872.1.
CCDSCCDS48584.1.
RefSeqNP_892037.2. NM_182992.2.
UniGeneMm.259767.

3D structure databases

ProteinModelPortalQ5DTJ9.
SMRQ5DTJ9. Positions 226-531, 940-1267.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5DTJ9.

Proteomic databases

MaxQBQ5DTJ9.
PaxDbQ5DTJ9.
PRIDEQ5DTJ9.

Protocols and materials databases

DNASU68802.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095580; ENSMUSP00000093240; ENSMUSG00000020067.
GeneID68802.
KEGGmmu:68802.
UCSCuc007fjy.2. mouse.

Organism-specific databases

CTD84665.
MGIMGI:1916052. Mypn.
RougeSearch...

Phylogenomic databases

eggNOGNOG136920.
GeneTreeENSGT00690000101977.
HOGENOMHOG000028074.
HOVERGENHBG059166.
InParanoidQ5DTJ9.
OMAQSHRGRS.
OrthoDBEOG77WWBP.
PhylomeDBQ5DTJ9.
TreeFamTF343193.

Gene expression databases

BgeeQ5DTJ9.
CleanExMM_MYPN.
GenevestigatorQ5DTJ9.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF07679. I-set. 5 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio327967.
PROQ5DTJ9.
SOURCESearch...

Entry information

Entry nameMYPN_MOUSE
AccessionPrimary (citable) accession number: Q5DTJ9
Secondary accession number(s): Q7TPW5, Q8BZ76
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot