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Q5DTJ9

- MYPN_MOUSE

UniProt

Q5DTJ9 - MYPN_MOUSE

Protein

Myopalladin

Gene

Mypn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.By similarity

    GO - Biological processi

    1. sarcomere organization Source: Ensembl

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myopalladin
    Gene namesi
    Name:Mypn
    Synonyms:Kiaa4170
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1916052. Mypn.

    Subcellular locationi

    Cytoplasm. Nucleus By similarity. Cytoplasmmyofibrilsarcomere
    Note: Bound to sarcomere both at the Z-line periphery and in the central I-band region.

    GO - Cellular componenti

    1. I band Source: BHF-UCL
    2. microtubule cytoskeleton Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13151315MyopalladinPRO_0000240490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991PhosphoserineBy similarity
    Modified residuei249 – 2491PhosphothreonineBy similarity
    Disulfide bondi288 ↔ 339PROSITE-ProRule annotation
    Disulfide bondi453 ↔ 512PROSITE-ProRule annotation
    Modified residuei754 – 7541PhosphoserineBy similarity
    Modified residuei809 – 8091PhosphoserineBy similarity
    Modified residuei814 – 8141PhosphoserineBy similarity
    Modified residuei924 – 9241PhosphoserineBy similarity
    Disulfide bondi1089 ↔ 1141PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ5DTJ9.
    PaxDbiQ5DTJ9.
    PRIDEiQ5DTJ9.

    PTM databases

    PhosphoSiteiQ5DTJ9.

    Expressioni

    Gene expression databases

    BgeeiQ5DTJ9.
    CleanExiMM_MYPN.
    GenevestigatoriQ5DTJ9.

    Interactioni

    Subunit structurei

    Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5DTJ9.
    SMRiQ5DTJ9. Positions 226-531, 940-1267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 35791Ig-like 1Add
    BLAST
    Domaini432 – 52897Ig-like 2Add
    BLAST
    Domaini941 – 102585Ig-like 3Add
    BLAST
    Domaini1068 – 115790Ig-like 4Add
    BLAST
    Domaini1167 – 125791Ig-like 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili219 – 24022Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi779 – 85274Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myotilin/palladin family.Curated

    Keywords - Domaini

    Coiled coil, Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG136920.
    GeneTreeiENSGT00690000101977.
    HOGENOMiHOG000028074.
    HOVERGENiHBG059166.
    InParanoidiQ5DTJ9.
    OMAiQSHRGRS.
    OrthoDBiEOG77WWBP.
    PhylomeDBiQ5DTJ9.
    TreeFamiTF343193.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF07679. I-set. 5 hits.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5DTJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEDSIEAST SISQLLRESY LAETRHRGDN ERSRAEPSSN PFHFSGPGAA     50
    EGGGPEDLPD LSAFLSQEEL DESVNLARLA INHDPLERVD EAQARKRLSS 100
    DQTKHASKPS FEPAFHQDSS RGPASPKDSP PETKRPQYSS ETQSKKVFLN 150
    KAADFIEELS SLFKAHSSKR IRPRACKNHK SKTESQNKVL QENSPTFSDL 200
    TERRERASVP IPIPADSRDN ELNHAIEQRE AKRREAELAA GEAAAGDSTP 250
    GSSPSSLYYE EPLGQPPRFT QKLRSREVPE GSRVQLDCIV VGIPPPQVRW 300
    YCEGKELENS PDIHIVQAGN LHSLTIAEAF EEDTGRYSCF ASNIYGTDST 350
    SAEIYIEGVS SSDSEGDPNK EEMNRIQKPN EVSSPPTTSA AIPPAAEAQP 400
    LAAQPRVSTV QQCQSPTNYL QGLNGKPIIA APVFTKMLQN LSASEGQLVV 450
    FECRVKGAPS PKVEWYREGT LIEDSPDFRI LQKKPRSMAE PEEICTLVIA 500
    EVFSEDSGCF TCTASNKYGT VSSIAQLDVR GNEDISDNGA LHSANSTTNP 550
    AVAEHQPSPL NPQPLSEEQP PKPKLEGVLV NHNEPRSSSR IGLRVHFNLP 600
    EDDKDMEASS GSGAANTSQT RPNSFPERFN GQEARIPEPS SPIKEPPPVL 650
    AKPKLDSTQL QQLHNQVLLE QQQLQNTSPS SPKESLHMSA LNSAPPAVTI 700
    SSKQVKGPAP QMFNLARPKH FFPASSTSTA TVSPSSSPVF TLSNTPQTIQ 750
    RTVSKESLLM AHPSTQGRSP GGLSIQNEPA PPSPAEPAAP PTAAYSIPSG 800
    NQFQPHCVSP TPVSPTGRIQ NPVAFLSSVL PSLPSIPPTN AMGLPKSAPS 850
    VPSQGLMKKT TKAPQAVSDD YIRETKNSVI LDLGKKVNFG DVRSHQQEYK 900
    ISSFEQRLMN EIEFRLERTP VDESDDEIEH DEIPTGKCIA PIFDKRLKHF 950
    RVTEGSPVTF TCKIVGIPVP KVYWFKDGKQ ISKRNEHCKM RREGDGTCSL 1000
    HIESTHGDDD GNYTIMAANP QGRISCSGHL MVQGLPIRSR LSPALSHRGR 1050
    SRMQERDKEP LQERFFRPHF LQAPGDMVAH EGRLCRLDCK VSGLPPPELT 1100
    WLLNGQPVLP DASHKMLVRE TGVHSLLIDP LTQRDAGTYT CVATNKTGQN 1150
    SFSLELTVVA KEVKKAPVIL EKLQNSGVPE GHPVRLEGRV IGMPPPVFYW 1200
    KKDNETIPFT RERISMHQDT TGYVCLLIQP AKKSDAGWYT LSAKNEAGIV 1250
    SCTARLDIYA QWHQQIPTPI SIRPSGSRYG SLTSKGLDIF SAFSSVESTM 1300
    LYSCTSRSVV ESDEL 1315
    Length:1,315
    Mass (Da):144,114
    Last modified:June 27, 2006 - v2
    Checksum:i3CBA735F63983B3F
    GO

    Sequence cautioni

    The sequence BAD90521.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1120 – 11201E → G in AAH52872. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK220521 mRNA. Translation: BAD90521.1. Different initiation.
    AK036458 mRNA. Translation: BAC29439.1.
    BC052872 mRNA. Translation: AAH52872.1.
    CCDSiCCDS48584.1.
    RefSeqiNP_892037.2. NM_182992.2.
    UniGeneiMm.259767.

    Genome annotation databases

    EnsembliENSMUST00000095580; ENSMUSP00000093240; ENSMUSG00000020067.
    GeneIDi68802.
    KEGGimmu:68802.
    UCSCiuc007fjy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK220521 mRNA. Translation: BAD90521.1 . Different initiation.
    AK036458 mRNA. Translation: BAC29439.1 .
    BC052872 mRNA. Translation: AAH52872.1 .
    CCDSi CCDS48584.1.
    RefSeqi NP_892037.2. NM_182992.2.
    UniGenei Mm.259767.

    3D structure databases

    ProteinModelPortali Q5DTJ9.
    SMRi Q5DTJ9. Positions 226-531, 940-1267.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5DTJ9.

    Proteomic databases

    MaxQBi Q5DTJ9.
    PaxDbi Q5DTJ9.
    PRIDEi Q5DTJ9.

    Protocols and materials databases

    DNASUi 68802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095580 ; ENSMUSP00000093240 ; ENSMUSG00000020067 .
    GeneIDi 68802.
    KEGGi mmu:68802.
    UCSCi uc007fjy.2. mouse.

    Organism-specific databases

    CTDi 84665.
    MGIi MGI:1916052. Mypn.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG136920.
    GeneTreei ENSGT00690000101977.
    HOGENOMi HOG000028074.
    HOVERGENi HBG059166.
    InParanoidi Q5DTJ9.
    OMAi QSHRGRS.
    OrthoDBi EOG77WWBP.
    PhylomeDBi Q5DTJ9.
    TreeFami TF343193.

    Miscellaneous databases

    NextBioi 327967.
    PROi Q5DTJ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5DTJ9.
    CleanExi MM_MYPN.
    Genevestigatori Q5DTJ9.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF07679. I-set. 5 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754.
      Strain: C57BL/6J.
      Tissue: Bone.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1053-1315.
      Strain: C57BL/6J.
      Tissue: Blastocyst.

    Entry informationi

    Entry nameiMYPN_MOUSE
    AccessioniPrimary (citable) accession number: Q5DTJ9
    Secondary accession number(s): Q7TPW5, Q8BZ76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3