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Protein

Teashirt homolog 1

Gene

Tshz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri246 – 27025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 33125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 44025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi891 – 96171Homeobox; atypicalAdd
BLAST
Zinc fingeri976 – 99823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1044 – 106724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • middle ear morphogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • soft palate development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 1
Alternative name(s):
Serologically defined colon cancer antigen 3 homolog
Gene namesi
Name:Tshz1
Synonyms:Kiaa4206, Sdccag33, Tsh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1346031. Tshz1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Normal Mendelian ratio at birth, but none of the mutant animals survive beyond P0. Newborn mutant mice exhibit a strong defect of the soft palate, vertebral malformations in the cervical and thoracic regions of the axial skeleton and malformations in the middle ear components.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10841084Teashirt homolog 1PRO_0000047063Add
BLAST

Proteomic databases

MaxQBiQ5DTH5.
PaxDbiQ5DTH5.
PRIDEiQ5DTH5.

PTM databases

iPTMnetiQ5DTH5.
PhosphoSiteiQ5DTH5.

Expressioni

Developmental stagei

From E12.5, expressed in the mesenchyme of the developing middle ear, within areas surrounding the condensing malleus and tympanic ring and on both sides of the external acoustic meatus. At 12.5 dpc, borders and surrounds the future cartilages, but excluded from cartilaginous condensations. Not detected in mesenchymal cells in proximal ureters at 14 dpc.2 Publications

Gene expression databases

BgeeiQ5DTH5.
CleanExiMM_TSHZ1.
GenevisibleiQ5DTH5. MM.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089388.

Structurei

3D structure databases

ProteinModelPortaliQ5DTH5.
SMRiQ5DTH5. Positions 232-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 195138Ser-richAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri246 – 27025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 33125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 44025C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri976 – 99823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1044 – 106724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJEQ. Eukaryota.
ENOG410XQQR. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ5DTH5.
KOiK09236.
OMAiKTKRWSK.
OrthoDBiEOG7NPFSF.
PhylomeDBiQ5DTH5.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026808. Tshz1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF6. PTHR12487:SF6. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5DTH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRKQQAPR RSAAYVPEEE LKAAEIDEEH AEDGGLSLDI QESEFACNEE
60 70 80 90 100
TEIKEAQSYQ NSPVSTATNQ DAGYGSPFSE GSDQLAHFKS SSSREEKEES
110 120 130 140 150
QCPDSVSYPQ DSLAQIKAVY ANLFSESCWS SLALDLKKSN SATSNNDASQ
160 170 180 190 200
KESSTPTPTP PTSTASTACT TATTAITSCS TSTSHSSTTS NSSSSGYDWH
210 220 230 240 250
QAALAKTLQQ TSSYGLLPEP SLFSTVQLYR QNNKLYGSVF TGASKFRCKD
260 270 280 290 300
CSAAYDTLVE LTVHMNETGH YRDDNRDKDS EKTKRWSKPR KRSLMEMEGK
310 320 330 340 350
EDAQKVLKCM YCGHSFESLQ DLSVHMIKTK HYQKVPLKEP VPAITKLVPS
360 370 380 390 400
TKKRALQDLA SPCSPEPTGV ATEVALSESA KDQKTANPYV TPNNRYGYQN
410 420 430 440 450
GASYTWQFEA RKAQILKCME CGSSHDTLQQ LTAHMMVTGH FLKVTTSASK
460 470 480 490 500
KGKQLVLDPV VEEKIQSIPL PPTTHTRLPA SSIKKQPDSP AGSVASEEKK
510 520 530 540 550
EPEKEKEKEK APPAAGDAER KIKEETEDAT EKFEPTALYQ YLREEDLDDS
560 570 580 590 600
PKGGVDILKS LENTVSTAIS KAQNGAPSWG GYPSIHAAYQ LPGTVKPLQS
610 620 630 640 650
AVQSVQIQPS YASSVKSLSS TEHNALLHSP GSLTPPPHKS NVSAMEELVE
660 670 680 690 700
KVTGKVSIKK EERPTEKEKS SPVKAISPVA KENKDLPKTE ETGSKPQKKG
710 720 730 740 750
SDSETGKAKK ESTLDAHTPN GTEPLKAKVT NGCGHLGIIT DHSPEPSFIN
760 770 780 790 800
PLSALQSIMN THLGKVSKPV SPSLDPLAML YKISNSMLDK PVYPTTPAKQ
810 820 830 840 850
ADAIDRYYYE NSDQPIDLTK SKNKPLVSGV ADAVSSPLRE SALMDISDMV
860 870 880 890 900
KNLTGRLTPK SSTPSTVSEK SDADGSSFEE ALDELSPVHK RKGRQSNWNP
910 920 930 940 950
QHLLILQAQF ASSLRETAEG KYIMSDLGPQ ERVHISKFTG LSMTTISHWL
960 970 980 990 1000
ANVKYQLRRT GGTKFLKNLD TGHPVFFCND CASQFRTAST YVSHLETHLG
1010 1020 1030 1040 1050
FSLKDLSKLP LSQIQEQQSV VSKALTNKTL GPLGSSEEDL GSTFQCKLCN
1060 1070 1080
RTFASKHAVK LHLSKTHGKS PEDHLIYVTE LEKQ
Length:1,084
Mass (Da):118,567
Last modified:January 10, 2006 - v2
Checksum:i22EB9A9132E62DC8
GO

Sequence cautioni

The sequence AAF63158.1 differs from that shown. Reason: Frameshift at positions 502 and 519. Curated
The sequence AAH58264.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD90534.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311A → S in AAF63158 (PubMed:10704881).Curated
Sequence conflicti140 – 1401N → S in AAF63158 (PubMed:10704881).Curated
Sequence conflicti1034 – 10341G → A in AAF63158 (PubMed:10704881).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220545 mRNA. Translation: BAD90534.1. Different initiation.
AF191309 mRNA. Translation: AAF63158.1. Frameshift.
BC017636 mRNA. Translation: AAH17636.1.
BC058264 mRNA. Translation: AAH58264.1. Different initiation.
CCDSiCCDS37876.1.
RefSeqiNP_001074769.1. NM_001081300.1.
UniGeneiMm.102136.

Genome annotation databases

EnsembliENSMUST00000060303; ENSMUSP00000089388; ENSMUSG00000046982.
GeneIDi110796.
KEGGimmu:110796.
UCSCiuc008ful.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220545 mRNA. Translation: BAD90534.1. Different initiation.
AF191309 mRNA. Translation: AAF63158.1. Frameshift.
BC017636 mRNA. Translation: AAH17636.1.
BC058264 mRNA. Translation: AAH58264.1. Different initiation.
CCDSiCCDS37876.1.
RefSeqiNP_001074769.1. NM_001081300.1.
UniGeneiMm.102136.

3D structure databases

ProteinModelPortaliQ5DTH5.
SMRiQ5DTH5. Positions 232-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089388.

PTM databases

iPTMnetiQ5DTH5.
PhosphoSiteiQ5DTH5.

Proteomic databases

MaxQBiQ5DTH5.
PaxDbiQ5DTH5.
PRIDEiQ5DTH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060303; ENSMUSP00000089388; ENSMUSG00000046982.
GeneIDi110796.
KEGGimmu:110796.
UCSCiuc008ful.1. mouse.

Organism-specific databases

CTDi10194.
MGIiMGI:1346031. Tshz1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJEQ. Eukaryota.
ENOG410XQQR. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ5DTH5.
KOiK09236.
OMAiKTKRWSK.
OrthoDBiEOG7NPFSF.
PhylomeDBiQ5DTH5.
TreeFamiTF328447.

Miscellaneous databases

ChiTaRSiTshz1. mouse.
PROiQ5DTH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ5DTH5.
CleanExiMM_TSHZ1.
GenevisibleiQ5DTH5. MM.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026808. Tshz1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF6. PTHR12487:SF6. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt."
    Caubit X., Core N., Boned A., Kerridge S., Djabali M., Fasano L.
    Mech. Dev. 91:445-448(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-1084.
    Tissue: Limb bud.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 281-1084.
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  4. "Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene."
    Manfroid I., Caubit X., Kerridge S., Fasano L.
    Development 131:1065-1073(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  5. "Tshz1 is required for axial skeleton, soft palate and middle ear development in mice."
    Core N., Caubit X., Metchat A., Boned A., Djabali M., Fasano L.
    Dev. Biol. 308:407-420(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  6. Cited for: INTERACTION WITH APBB1.
  7. "Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction."
    Jenkins D., Caubit X., Dimovski A., Matevska N., Lye C.M., Cabuk F., Gucev Z., Tasic V., Fasano L., Woolf A.S.
    Nephrol. Dial. Transplant. 25:54-60(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTSH1_MOUSE
AccessioniPrimary (citable) accession number: Q5DTH5
Secondary accession number(s): Q6PE60, Q8VD19, Q9JLD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.