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Protein
Submitted name:

MKIAA4216 protein

Gene

Ube3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA4216 proteinImported
Gene namesi
Name:Ube3aImported
Synonyms:mKIAA4216Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:105098. Ube3a.

PTM / Processingi

Proteomic databases

MaxQBiQ5DTH1.
PaxDbiQ5DTH1.

Expressioni

Gene expression databases

GenevisibleiQ5DTH1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103161.

Structurei

3D structure databases

ProteinModelPortaliQ5DTH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini578 – 906329HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000261634.
HOVERGENiHBG059326.
KOiK10587.
PhylomeDBiQ5DTH1.

Family and domain databases

InterProiIPR032353. AZUL.
IPR000569. HECT_dom.
IPR017134. UBE3A.
[Graphical view]
PfamiPF16558. AZUL. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
PIRSFiPIRSF037201. Ubiquitin-protein_ligase_E6-AP. 1 hit.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5DTH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DPAVAPAKGN EAVAGGGGGR GRQGPVRRPQ LRGPQPTRGG EDRSPGESQS
60 70 80 90 100
EDIEASRMKR AAAKHLIERY YHQLTEGCGN EACTNEFCAS CPTFLRMDNN
110 120 130 140 150
AAAIKALELY KINAKLCDPH PSKKGASSAY LENSKGASNN SEIKMNKKEG
160 170 180 190 200
KDFKDVIYLT EEKVYEIYEF CRESEDYSPL IRVIGRIFSS AEALVLSFRK
210 220 230 240 250
VKQHTKEELK SLQEKDEDKD EDEKEKAACS AAAMEEDSEA SSSRMGDSSQ
260 270 280 290 300
GDNNVQKLGP DDVTVDIDAI RRVYSSLLAN EKLETAFLNA LVYLSPNVEC
310 320 330 340 350
DLTYHNVYTR DPNYLNLFII VMENSNLHSP EYLEMALPLF CKAMCKLPLE
360 370 380 390 400
AQGKLIRLWS KYSADQIRRM METFQQLITY KVISNEFNSR NLVNDDDAIV
410 420 430 440 450
AASKCLKMVY YANVVGGDVD TNHNEEDDEE PIPESSELTL QELLGDERRN
460 470 480 490 500
KKGPRVDPLE TELGVKTLDC RKPLISFEEF INEPLNDVLE MDKDYTFFKV
510 520 530 540 550
ETENKFSFMT CPFILNAVTK NLGLYYDNRI RMYSERRITV LYSLVQGQQL
560 570 580 590 600
NPYLRLKVRR DHIIDDALVR LEMIAMENPA DLKKQLYVEF EGEQGVDEGG
610 620 630 640 650
VSKEFFQLVV EEIFNPDIGM FTYDEATKLF WFNPSSFETE GQFTLIGIVL
660 670 680 690 700
GLAIYNNCIL DVHFPMVVYR KLMGKKGTFR DLGDSHPVLY QSLKDLLEYE
710 720 730 740 750
GSVEDDMMIT FQISQTDLFG NPMMYDLKEN GDKIPITNEN RKEFVNLYSD
760 770 780 790 800
YILNKSVEKQ FKAFRRGFHM VTNESPLKYL FRPEEIELLI CGSRNLDFQA
810 820 830 840 850
LEETTEYDGG YTRESVVIRE FWEIVHSFTD EQKRLFLQFT TGTDRAPVGG
860 870 880 890 900
LGKLKMIIAK NGPDTERLPT SHTCFNVLLL PEYSSKEKLK ERLLKAITYA

KGFGML
Length:906
Mass (Da):103,343
Last modified:March 29, 2005 - v1
Checksum:iF588CBBAA5F3C8DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220549 mRNA. Translation: BAD90321.1.
RefSeqiNP_001029134.1. NM_001033962.1.
NP_035798.2. NM_011668.2.
UniGeneiMm.9002.

Genome annotation databases

GeneIDi22215.
KEGGimmu:22215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220549 mRNA. Translation: BAD90321.1.
RefSeqiNP_001029134.1. NM_001033962.1.
NP_035798.2. NM_011668.2.
UniGeneiMm.9002.

3D structure databases

ProteinModelPortaliQ5DTH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103161.

Proteomic databases

MaxQBiQ5DTH1.
PaxDbiQ5DTH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22215.
KEGGimmu:22215.

Organism-specific databases

CTDi7337.
MGIiMGI:105098. Ube3a.

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000261634.
HOVERGENiHBG059326.
KOiK10587.
PhylomeDBiQ5DTH1.

Miscellaneous databases

ChiTaRSiUbe3a. mouse.
NextBioi302217.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ5DTH1. MM.

Family and domain databases

InterProiIPR032353. AZUL.
IPR000569. HECT_dom.
IPR017134. UBE3A.
[Graphical view]
PfamiPF16558. AZUL. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
PIRSFiPIRSF037201. Ubiquitin-protein_ligase_E6-AP. 1 hit.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene. The Complete Nucleotide Sequences of Mouse KIAA-homologous cDNAs Identified by Screening of Terminal sequences of cDNA Clones Randomly Sampled from Size-Fractionated Libraries.."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal brainImported.

Entry informationi

Entry nameiQ5DTH1_MOUSE
AccessioniPrimary (citable) accession number: Q5DTH1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.