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Protein

UDP-glucuronosyltransferase

Gene

UGT1A6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:UGT1A6Imported
ORF Names:hCG_2039726Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000167165.18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei490 – 513HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37181

PTM / Processingi

Proteomic databases

MaxQBiQ5DSZ8

Expressioni

Gene expression databases

BgeeiENSG00000167165
ExpressionAtlasiQ5DSZ8 baseline and differential

Structurei

3D structure databases

SMRiQ5DSZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 396UDPGTInterPro annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili412 – 432Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
HOVERGENiHBG004033
KOiK00699
OMAiESKHYTR
OrthoDBiEOG091G06JC

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5DSZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLLRSFQR ISAGVFFLAL WGMVVGDKLL VVPQDGSHWL SMKDIVEVLS
60 70 80 90 100
DRGHEIVVVV PEVNLLLKES KYYTRKIYPV PYDQEELKNR YQSFGNNHFA
110 120 130 140 150
ERSFLTAPQT EYRNNMIVIG LYFINCQSLL QDRDTLNFFK ESKFDALFTD
160 170 180 190 200
PALPCGVILA EYLGLPSVYL FRGFPCSLEH TFSRSPDPVS YIPRCYTKFS
210 220 230 240 250
DHMTFSQRVA NFLVNLLEPY LFYCLFSKYE ELASAVLKRD VDIITLYQKV
260 270 280 290 300
SVWLLRYDFV LEYPRPVMPN MVFIGGINCK KRKDLSQEFE AYINASGEHG
310 320 330 340 350
IVVFSLGSMV SEIPEKKAMA IADALGKIPQ TVLWRYTGTR PSNLANNTIL
360 370 380 390 400
VKWLPQNDLL GHPMTRAFIT HAGSHGVYES ICNGVPMVMM PLFGDQMDNA
410 420 430 440 450
KRMETKGAGV TLNVLEMTSE DLENALKAVI NDKSYKENIM RLSSLHKDRP
460 470 480 490 500
VEPLDLAVFW VEFVMRHKGA PHLRPAAHDL TWYQYHSLDV IGFLLAVVLT
510 520 530
VAFITFKCCA YGYRKCLGKK GRVKKAHKSK TH
Length:532
Mass (Da):60,751
Last modified:May 10, 2005 - v1
Checksum:i4A9EA6A88CBC3136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY435141 mRNA Translation: AAR95642.1
CH471063 Genomic DNA Translation: EAW71055.1
RefSeqiNP_001063.2, NM_001072.3
UniGeneiHs.554822

Genome annotation databases

GeneIDi54578
KEGGihsa:54578
UCSCiuc002vuv.5 human

Similar proteinsi

Entry informationi

Entry nameiQ5DSZ8_HUMAN
AccessioniPrimary (citable) accession number: Q5DSZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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