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Protein

UDP-glucuronosyltransferase

Gene

UGT1A9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:UGT1A9Imported
ORF Names:hCG_2039726Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei488 – 51124HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525UniRule annotationAdd
BLAST
Chaini26 – 530505UDP-glucuronosyltransferaseUniRule annotationPRO_5007364894Add
BLAST

Expressioni

Gene expression databases

BgeeiENSG00000241119.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346768.

Structurei

3D structure databases

SMRiQ5DSZ5. Positions 222-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOVERGENiHBG004033.
KOiK00699.
OMAiMLISSEN.
OrthoDBiEOG091G06JC.
PhylomeDBiQ5DSZ5.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5DSZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA
110 120 130 140 150
QVRSIYSLLM GSYNDIFDLF FSNCRSLFKD KKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DNCGLIVAKY FSLPSVVFAR GILCHYLEEG AQCPAPLSYV PRILLGFSDA
210 220 230 240 250
MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT EYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,941
Last modified:May 10, 2005 - v1
Checksum:iC417B9E86B403078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY435144 mRNA. Translation: AAR95645.1.
AK313510 mRNA. Translation: BAG36290.1.
CH471063 Genomic DNA. Translation: EAW71054.1.
RefSeqiNP_066307.1. NM_021027.2.
UniGeneiHs.554822.

Genome annotation databases

GeneIDi54600.
KEGGihsa:54600.
UCSCiuc002vus.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY435144 mRNA. Translation: AAR95645.1.
AK313510 mRNA. Translation: BAG36290.1.
CH471063 Genomic DNA. Translation: EAW71054.1.
RefSeqiNP_066307.1. NM_021027.2.
UniGeneiHs.554822.

3D structure databases

SMRiQ5DSZ5. Positions 222-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346768.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

DNASUi54600.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54600.
KEGGihsa:54600.
UCSCiuc002vus.4. human.

Organism-specific databases

CTDi54600.
PharmGKBiPA419.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOVERGENiHBG004033.
KOiK00699.
OMAiMLISSEN.
OrthoDBiEOG091G06JC.
PhylomeDBiQ5DSZ5.

Miscellaneous databases

GenomeRNAii54600.

Gene expression databases

BgeeiENSG00000241119.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5DSZ5_HUMAN
AccessioniPrimary (citable) accession number: Q5DSZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.