Q5DQR4 (STB5L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-binding protein 5-like

Alternative name(s):
Lethal(2) giant larvae protein homolog 4
Tomosyn-2

Gene names

Name:	Stxbp5l
Synonyms:	Llgl4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicle trafficking and exocytosis Potential.
Subcellular location	Cytoplasm Potential. Cell membrane; Peripheral membrane protein Potential. Membrane; Peripheral membrane protein Potential. Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane Potential.
Tissue specificity	Detected in hippocampus and cerebellum. Ref.1
Sequence similarities	Belongs to the WD repeat L(2)GL family. Contains 1 v-SNARE coiled-coil homology domain. Contains 14 WD repeats.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5DQR4-1)

Also known as: Tomosyn-2 isoform xb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5DQR4-2)

Also known as: Tomosyn-2 isoform m;

The sequence of this isoform differs from the canonical sequence as follows:
     749-805: Missing.

Isoform 3 (identifier: Q5DQR4-3)

Also known as: Tomosyn-2 isoform b;

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G

Isoform 4 (identifier: Q5DQR4-4)

Also known as: Tomosyn-2 isoform s;

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     749-805: Missing.

Isoform 5 (identifier: Q5DQR4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     1006-1025: SLPSLRPMLDVNYLPLTDMR → RYMVYLLLTDNHNNASKVKW
     1026-1185: Missing.

Isoform 6 (identifier: Q5DQR4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     467-1185: Missing.

Isoform 7 (identifier: Q5DQR4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     157-1185: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1185	1185	Syntaxin-binding protein 5-like		PRO_0000051248
Regions
	Repeat	73 – 106	34	WD 1
	Repeat	113 – 152	40	WD 2
	Repeat	157 – 193	37	WD 3
	Repeat	212 – 246	35	WD 4
	Repeat	252 – 284	33	WD 5
	Repeat	306 – 348	43	WD 6
	Repeat	356 – 390	35	WD 7
	Repeat	412 – 489	78	WD 8
	Repeat	517 – 628	112	WD 9
	Repeat	642 – 704	63	WD 10
	Repeat	831 – 888	58	WD 11
	Repeat	897 – 968	72	WD 12
	Repeat	973 – 1017	45	WD 13
	Repeat	1031 – 1054	24	WD 14
	Domain	1120 – 1180	61	v-SNARE coiled-coil homology
Amino acid modifications
	Modified residue	588	1	Phosphoserine Ref.3
	Modified residue	590	1	Phosphoserine Ref.3
	Modified residue	593	1	Phosphothreonine Ref.3
	Modified residue	598	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	157 – 1185	1029	Missing in isoform 7.		VSP_016300
	Alternative sequence	467 – 1185	719	Missing in isoform 6.		VSP_016299
	Alternative sequence	703 – 727	25	DNFCM…TSYQS → G in isoform 3, isoform 4 and isoform 5.		VSP_016295
	Alternative sequence	749 – 805	57	Missing in isoform 2 and isoform 4.		VSP_016296
	Alternative sequence	1006 – 1025	20	SLPSL…LTDMR → RYMVYLLLTDNHNNASKVKW in isoform 5.		VSP_016297
	Alternative sequence	1026 – 1185	160	Missing in isoform 5.		VSP_016298

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Tomosyn-2 isoform xb) [UniParc]. Last modified March 29, 2005. Version 1. Checksum: 0F797A5CF20E05DC	FASTA	1,185	131,844
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 470 480 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 490 500 510 520 530 540 TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 550 560 570 580 590 600 KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 610 620 630 640 650 660 VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 670 680 690 700 710 720 LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IADNFCMRGL SNFYPDLTKR 730 740 750 760 770 780 IRTSYQSLTE LNDSPVPLEL ERCKSPTSDH VNGHCTSPTS QSCSSGKRLS SADVSKVNRW 790 800 810 820 830 840 GPGRPPFRKA QSAACMEISL PVTTEETREN SYNRSRSSSI SSIDKDSKEA ITALYFMESF 850 860 870 880 890 900 ARKNDSTVSP CLFVGTSLGM VVLISLNLPS SDEQRFTEPV VVLPSGTFLS LKGAVLTFSC 910 920 930 940 950 960 MDRTGSLMQP PYEVWRDPNN TDENEKTWKR KLVMNYSSSS QEMGDHQYTI ICSEKQAKVF 970 980 990 1000 1010 1020 SLPSQTCLYV HNITETSFIL QADVVVMCNS ACLACFCANG HIMIMSLPSL RPMLDVNYLP 1030 1040 1050 1060 1070 1080 LTDMRIARTF CFTNEGQALY LVSPTEIQRL TYSQEMCDNI QDMLGDLFTP IETPEAQNRG 1090 1100 1110 1120 1130 1140 FLKGLFGGSG QTFDREELFG EASAGKASRS LAQHIPGPGS IEGMKGAAGG VMGELTRARI 1150 1160 1170 1180 ALDERGQRLG ELEEKTAGMM TSAEAFSKHA HELMLKYKDK KWYQF
	Isoform 2 (Tomosyn-2 isoform m) [UniParc]. Checksum: 47124F194BC9517B	FASTA	1,128	125,805
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 470 480 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 490 500 510 520 530 540 TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 550 560 570 580 590 600 KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 610 620 630 640 650 660 VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 670 680 690 700 710 720 LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IADNFCMRGL SNFYPDLTKR 730 740 750 760 770 780 IRTSYQSLTE LNDSPVPLEL ERCKSPTSET RENSYNRSRS SSISSIDKDS KEAITALYFM 790 800 810 820 830 840 ESFARKNDST VSPCLFVGTS LGMVVLISLN LPSSDEQRFT EPVVVLPSGT FLSLKGAVLT 850 860 870 880 890 900 FSCMDRTGSL MQPPYEVWRD PNNTDENEKT WKRKLVMNYS SSSQEMGDHQ YTIICSEKQA 910 920 930 940 950 960 KVFSLPSQTC LYVHNITETS FILQADVVVM CNSACLACFC ANGHIMIMSL PSLRPMLDVN 970 980 990 1000 1010 1020 YLPLTDMRIA RTFCFTNEGQ ALYLVSPTEI QRLTYSQEMC DNIQDMLGDL FTPIETPEAQ 1030 1040 1050 1060 1070 1080 NRGFLKGLFG GSGQTFDREE LFGEASAGKA SRSLAQHIPG PGSIEGMKGA AGGVMGELTR 1090 1100 1110 1120 ARIALDERGQ RLGELEEKTA GMMTSAEAFS KHAHELMLKY KDKKWYQF
	Isoform 3 (Tomosyn-2 isoform b) [UniParc]. Checksum: C5F84EE231D77E22	FASTA	1,161	128,906
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 470 480 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 490 500 510 520 530 540 TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 550 560 570 580 590 600 KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 610 620 630 640 650 660 VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 670 680 690 700 710 720 LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IAGLTELNDS PVPLELERCK 730 740 750 760 770 780 SPTSDHVNGH CTSPTSQSCS SGKRLSSADV SKVNRWGPGR PPFRKAQSAA CMEISLPVTT 790 800 810 820 830 840 EETRENSYNR SRSSSISSID KDSKEAITAL YFMESFARKN DSTVSPCLFV GTSLGMVVLI 850 860 870 880 890 900 SLNLPSSDEQ RFTEPVVVLP SGTFLSLKGA VLTFSCMDRT GSLMQPPYEV WRDPNNTDEN 910 920 930 940 950 960 EKTWKRKLVM NYSSSSQEMG DHQYTIICSE KQAKVFSLPS QTCLYVHNIT ETSFILQADV 970 980 990 1000 1010 1020 VVMCNSACLA CFCANGHIMI MSLPSLRPML DVNYLPLTDM RIARTFCFTN EGQALYLVSP 1030 1040 1050 1060 1070 1080 TEIQRLTYSQ EMCDNIQDML GDLFTPIETP EAQNRGFLKG LFGGSGQTFD REELFGEASA 1090 1100 1110 1120 1130 1140 GKASRSLAQH IPGPGSIEGM KGAAGGVMGE LTRARIALDE RGQRLGELEE KTAGMMTSAE 1150 1160 AFSKHAHELM LKYKDKKWYQ F
	Isoform 4 (Tomosyn-2 isoform s) [UniParc]. Checksum: 433FE26AE29E1903	FASTA	1,104	122,866
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 470 480 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 490 500 510 520 530 540 TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 550 560 570 580 590 600 KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 610 620 630 640 650 660 VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 670 680 690 700 710 720 LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IAGLTELNDS PVPLELERCK 730 740 750 760 770 780 SPTSETRENS YNRSRSSSIS SIDKDSKEAI TALYFMESFA RKNDSTVSPC LFVGTSLGMV 790 800 810 820 830 840 VLISLNLPSS DEQRFTEPVV VLPSGTFLSL KGAVLTFSCM DRTGSLMQPP YEVWRDPNNT 850 860 870 880 890 900 DENEKTWKRK LVMNYSSSSQ EMGDHQYTII CSEKQAKVFS LPSQTCLYVH NITETSFILQ 910 920 930 940 950 960 ADVVVMCNSA CLACFCANGH IMIMSLPSLR PMLDVNYLPL TDMRIARTFC FTNEGQALYL 970 980 990 1000 1010 1020 VSPTEIQRLT YSQEMCDNIQ DMLGDLFTPI ETPEAQNRGF LKGLFGGSGQ TFDREELFGE 1030 1040 1050 1060 1070 1080 ASAGKASRSL AQHIPGPGSI EGMKGAAGGV MGELTRARIA LDERGQRLGE LEEKTAGMMT 1090 1100 SAEAFSKHAH ELMLKYKDKK WYQF
	Isoform 5 [UniParc]. Checksum: 03E8C91B2C5F16E4	FASTA	1,001	111,411
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 470 480 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 490 500 510 520 530 540 TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 550 560 570 580 590 600 KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 610 620 630 640 650 660 VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 670 680 690 700 710 720 LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IAGLTELNDS PVPLELERCK 730 740 750 760 770 780 SPTSDHVNGH CTSPTSQSCS SGKRLSSADV SKVNRWGPGR PPFRKAQSAA CMEISLPVTT 790 800 810 820 830 840 EETRENSYNR SRSSSISSID KDSKEAITAL YFMESFARKN DSTVSPCLFV GTSLGMVVLI 850 860 870 880 890 900 SLNLPSSDEQ RFTEPVVVLP SGTFLSLKGA VLTFSCMDRT GSLMQPPYEV WRDPNNTDEN 910 920 930 940 950 960 EKTWKRKLVM NYSSSSQEMG DHQYTIICSE KQAKVFSLPS QTCLYVHNIT ETSFILQADV 970 980 990 1000 VVMCNSACLA CFCANGHIMI MRYMVYLLLT DNHNNASKVK W
	Isoform 6 [UniParc]. Checksum: 85DC0F23D3781F2E	FASTA	466	51,948
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 160 170 180 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 190 200 210 220 230 240 VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 250 260 270 280 290 300 RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 310 320 330 340 350 360 SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 370 380 390 400 410 420 TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 430 440 450 460 PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITG
	Isoform 7 [UniParc]. Checksum: 6C22D96E34DFFDB9	FASTA	156	16,726
	10 20 30 40 50 60 MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 70 80 90 100 110 120 CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 130 140 150 NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain." Groffen A.J.A., Jacobsen L., Schut D., Verhage M. J. Neurochem. 92:554-568(2005) [PubMed: 15659226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY. Strain: 129/Ola.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7). Strain: C57BL/6J. Tissue: Cerebellum, Embryo and Olfactory bulb.
[3]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588; SER-590; THR-593 AND SER-598, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY542354 , AY542328, AY542329, AY542331, AY542330, AY542332, AY542334, AY542336, AY542338, AY542340, AY542349, AY542348, AY542347, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542337, AY542335, AY542333 Genomic DNA. Translation: AAT68171.1. AY542354 , AY542328, AY542329, AY542330, AY542332, AY542335, AY542334, AY542333, AY542331, AY542336, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542337, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347 Genomic DNA. Translation: AAT68172.1. AY542354 , AY542328, AY542329, AY542331, AY542332, AY542330, AY542333, AY542335, AY542337, AY542340, AY542349, AY542348, AY542347, AY542345, AY542338, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542336, AY542334 Genomic DNA. Translation: AAT68173.1. AY542354 , AY542329, AY542330, AY542328, AY542331, AY542333, AY542335, AY542337, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347, AY542336, AY542334, AY542332 Genomic DNA. Translation: AAT68174.1. AY542324 mRNA. Translation: AAT68175.1. AY542325 mRNA. Translation: AAT68176.1. AY542326 mRNA. Translation: AAT68177.1. AY542327 mRNA. Translation: AAT68178.1. AK035159 mRNA. Translation: BAC28964.1. AK137325 mRNA. Translation: BAE23307.1. AK161955 mRNA. Translation: BAE36652.1.
IPI	IPI00309953. IPI00555072. IPI00555114. IPI00656181. IPI00656218. IPI00656258. IPI00656281.
RefSeq	NP_001108083.1. NM_001114611.1. NP_001108084.1. NM_001114612.1. NP_001108085.1. NM_001114613.1. NP_766028.2. NM_172440.3.
UniGene	Mm.403226. Mm.80170.
3D structure databases
ProteinModelPortal	Q5DQR4.
SMR	Q5DQR4. Positions 206-283, 515-543, 1121-1177.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5DQR4. 1 interaction.
STRING	Q5DQR4.
PTM databases
PhosphoSite	Q5DQR4.
Proteomic databases
PRIDE	Q5DQR4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023526; ENSMUSP00000023526; ENSMUSG00000022829. ENSMUST00000114775; ENSMUSP00000110423; ENSMUSG00000022829. ENSMUST00000114780; ENSMUSP00000110428; ENSMUSG00000022829. ENSMUST00000114781; ENSMUSP00000110429; ENSMUSG00000022829. ENSMUST00000114782; ENSMUSP00000110430; ENSMUSG00000022829. ENSMUST00000114787; ENSMUSP00000110435; ENSMUSG00000022829.
GeneID	207227.
KEGG	mmu:207227.
UCSC	uc007zds.2. mouse. uc007zdt.2. mouse. uc007zdu.2. mouse. uc007zdv.2. mouse. uc007zdw.2. mouse. uc007zdx.2. mouse. uc007zdy.2. mouse.
Organism-specific databases
CTD	9515.
MGI	MGI:2443815. Stxbp5l.
Phylogenomic databases
eggNOG	NOG289584.
GeneTree	ENSGT00390000000018.
HOVERGEN	HBG083064.
InParanoid	Q5DQR4.
KO	K08518.
OMA	IRTSYQS.
Gene expression databases
ArrayExpress	Q5DQR4.
Bgee	Q5DQR4.
CleanEx	MM_STXBP5L.
Genevestigator	Q5DQR4.
Family and domain databases
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
InterPro	IPR000664. Lethal2_giant. IPR013905. Lgl_C. IPR013577. LLGL2. IPR001388. Synaptobrevin. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF08596. Lgl_C. 1 hit. PF08366. LLGL. 1 hit. PF00400. WD40. 2 hits. [Graphical view]
PRINTS	PR00962. LETHAL2GIANT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS50892. V_SNARE. 1 hit. PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	371908.
SOURCE	Search...

Entry information

Entry name

STB5L_MOUSE

Accession

Primary (citable) accession number: Q5DQR4
Secondary accession number(s): Q3TSM3 , Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	March 29, 2005
Last modified:	April 18, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program