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Reviewed, UniProtKB/Swiss-Prot Q5DQR4 (STB5L_MOUSE)

Last modified July 22, 2008. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Syntaxin-binding protein 5-like
Alternative name(s):
    Tomosyn-2
    Lethal(2) giant larvae protein homolog 4
Gene names
Name: Stxbp5l
Synonyms: Llgl4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in vesicle trafficking and exocytosis Potential.

Subcellular location

CytoplasmPotential. Cell membrane; Peripheral membrane proteinPotential. Membrane; Peripheral membrane proteinPotential. Note= Cytoplasmic, and associated with vesicular membranes and the plasma membrane Potential.

Tissue specificity

Detected in hippocampus and cerebellum.

Sequence similarities

Belongs to the WD repeat L(2)GL family.

Contains 1 v-SNARE coiled-coil homology domain.

Contains 6 WD repeats.

Ontologies

Keywords

   Biological processProtein transport
Transport
   Cellular componentCell membrane
Cytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
WD repeat
   PTMPhosphoprotein

Gene Ontology (GO)

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5DQR4-1)

Also known as: Tomosyn-2 isoform xb;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5DQR4-2)

Also known as: Tomosyn-2 isoform m;

The sequence of this isoform differs from the canonical sequence as follows:
     749-805: Missing.
Isoform 3 (identifier: Q5DQR4-3)

Also known as: Tomosyn-2 isoform b;

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
Isoform 4 (identifier: Q5DQR4-4)

Also known as: Tomosyn-2 isoform s;

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     749-805: Missing.
Isoform 5 (identifier: Q5DQR4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     1006-1025: SLPSLRPMLDVNYLPLTDMR → RYMVYLLLTDNHNNASKVKW
     1026-1185: Missing.
Isoform 6 (identifier: Q5DQR4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     467-1185: Missing.
Isoform 7 (identifier: Q5DQR4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     157-1185: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 11851185Syntaxin-binding protein 5-like

Regions

Repeat67 – 10640WD 1
Repeat108 – 14740WD 2
Repeat205 – 24541WD 3
Repeat247 – 28640WD 4
Repeat442 – 48544WD 5
Repeat511 – 55040WD 6
Domain1120 – 118061v-SNARE coiled-coil homology

Amino acid modifications

Modified residue5881Phosphoserine
Modified residue5901Phosphoserine
Modified residue5931Phosphothreonine
Modified residue5981Phosphoserine

Natural variations

Alternative sequence157 – 11851029Missing in isoform 7.
Alternative sequence467 – 1185719Missing in isoform 6.
Alternative sequence703 – 72725DNFCM…TSYQS → G in isoform 3, isoform 4 and isoform 5.
Alternative sequence749 – 80557Missing in isoform 2 and isoform 4.
Alternative sequence1006 – 102520SLPSL…LTDMR → RYMVYLLLTDNHNNASKVKW in isoform 5.
Alternative sequence1026 – 1185160Missing in isoform 5.

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Tomosyn-2 isoform xb) [UniParc].

Last modified March 29, 2005. Version 1.
Checksum: 0F797A5CF20E05DC

FASTA1,185131,844
        10         20         30         40         50         60 
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 

        70         80         90        100        110        120 
CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 

       130        140        150        160        170        180 
NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 

       190        200        210        220        230        240 
VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 

       250        260        270        280        290        300 
RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 

       310        320        330        340        350        360 
SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 

       370        380        390        400        410        420 
TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 

       430        440        450        460        470        480 
PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 

       490        500        510        520        530        540 
TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 

       550        560        570        580        590        600 
KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 

       610        620        630        640        650        660 
VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 

       670        680        690        700        710        720 
LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IADNFCMRGL SNFYPDLTKR 

       730        740        750        760        770        780 
IRTSYQSLTE LNDSPVPLEL ERCKSPTSDH VNGHCTSPTS QSCSSGKRLS SADVSKVNRW 

       790        800        810        820        830        840 
GPGRPPFRKA QSAACMEISL PVTTEETREN SYNRSRSSSI SSIDKDSKEA ITALYFMESF 

       850        860        870        880        890        900 
ARKNDSTVSP CLFVGTSLGM VVLISLNLPS SDEQRFTEPV VVLPSGTFLS LKGAVLTFSC 

       910        920        930        940        950        960 
MDRTGSLMQP PYEVWRDPNN TDENEKTWKR KLVMNYSSSS QEMGDHQYTI ICSEKQAKVF 

       970        980        990       1000       1010       1020 
SLPSQTCLYV HNITETSFIL QADVVVMCNS ACLACFCANG HIMIMSLPSL RPMLDVNYLP 

      1030       1040       1050       1060       1070       1080 
LTDMRIARTF CFTNEGQALY LVSPTEIQRL TYSQEMCDNI QDMLGDLFTP IETPEAQNRG 

      1090       1100       1110       1120       1130       1140 
FLKGLFGGSG QTFDREELFG EASAGKASRS LAQHIPGPGS IEGMKGAAGG VMGELTRARI 

      1150       1160       1170       1180 
ALDERGQRLG ELEEKTAGMM TSAEAFSKHA HELMLKYKDK KWYQF 

« Hide

Isoform 2 (Tomosyn-2 isoform m) [UniParc].

Checksum: 47124F194BC9517B
Show »

1,128125,805
Isoform 3 (Tomosyn-2 isoform b) [UniParc].

Checksum: C5F84EE231D77E22
Show »

1,161128,906
Isoform 4 (Tomosyn-2 isoform s) [UniParc].

Checksum: 433FE26AE29E1903
Show »

1,104122,866
Isoform 5 [UniParc].

Checksum: 03E8C91B2C5F16E4
Show »

1,001111,411
Isoform 6 [UniParc].

Checksum: 85DC0F23D3781F2E
Show »

46651,948
Isoform 7 [UniParc].

Checksum: 6C22D96E34DFFDB9
Show »

15616,726

References

« Hide 'large scale' references
[1]"Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain."
Groffen A.J.A., Jacobsen L., Schut D., Verhage M.
J. Neurochem. 92:554-568(2005) [PubMed: 15659226] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
Strain: 129/Ola.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7).
Strain: C57BL/6J.
Tissue: Cerebellum, Embryo and Olfactory bulb.
[3]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588; SER-590; THR-593 AND SER-598, MASS SPECTROMETRY.
Tissue: Brain cortex.