Reviewed,
UniProtKB/Swiss-Prot Q5DQR4 (STB5L_MOUSE)
Last modified
July 22, 2008.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Syntaxin-binding protein 5-like Alternative name(s): Tomosyn-2 Lethal(2) giant larvae protein homolog 4 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1185 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in vesicle trafficking and exocytosis Potential. |
| Subcellular location | CytoplasmPotential. Cell membrane; Peripheral membrane proteinPotential. Membrane; Peripheral membrane proteinPotential. Note= Cytoplasmic, and associated with vesicular membranes and the plasma membrane Potential. |
| Tissue specificity | Detected in hippocampus and cerebellum. |
| Sequence similarities | Belongs to the WD repeat L(2)GL family. Contains 1 v-SNARE coiled-coil homology domain. Contains 6 WD repeats. |
Ontologies
Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Cell membrane Cytoplasm Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil Repeat WD repeat |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Alternative products
| This entry describes 7 isoforms produced by alternative splicing. [Align] [Select] | |||||
| Isoform 1 (identifier: Q5DQR4-1) Also known as: Tomosyn-2 isoform xb; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | |||||
| Isoform 2 (identifier: Q5DQR4-2) Also known as: Tomosyn-2 isoform m; The sequence of this isoform differs from the canonical sequence as follows: 749-805: Missing. | |||||
| Isoform 3 (identifier: Q5DQR4-3) Also known as: Tomosyn-2 isoform b; The sequence of this isoform differs from the canonical sequence as follows: 703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G | |||||
| Isoform 4 (identifier: Q5DQR4-4) Also known as: Tomosyn-2 isoform s; The sequence of this isoform differs from the canonical sequence as follows: 703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G 749-805: Missing. | |||||
| Isoform 5 (identifier: Q5DQR4-5) The sequence of this isoform differs from the canonical sequence as follows: 703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G 1006-1025: SLPSLRPMLDVNYLPLTDMR → RYMVYLLLTDNHNNASKVKW 1026-1185: Missing. | |||||
| Isoform 6 (identifier: Q5DQR4-6) The sequence of this isoform differs from the canonical sequence as follows: 467-1185: Missing. | |||||
| Isoform 7 (identifier: Q5DQR4-7) The sequence of this isoform differs from the canonical sequence as follows: 157-1185: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1185 | 1185 | Syntaxin-binding protein 5-like | |||||
Regions | ||||||||
| Repeat | 67 – 106 | 40 | WD 1 | |||||
| Repeat | 108 – 147 | 40 | WD 2 | |||||
| Repeat | 205 – 245 | 41 | WD 3 | |||||
| Repeat | 247 – 286 | 40 | WD 4 | |||||
| Repeat | 442 – 485 | 44 | WD 5 | |||||
| Repeat | 511 – 550 | 40 | WD 6 | |||||
| Domain | 1120 – 1180 | 61 | v-SNARE coiled-coil homology | |||||
Amino acid modifications | ||||||||
| Modified residue | 588 | 1 | Phosphoserine | |||||
| Modified residue | 590 | 1 | Phosphoserine | |||||
| Modified residue | 593 | 1 | Phosphothreonine | |||||
| Modified residue | 598 | 1 | Phosphoserine | |||||
Natural variations | ||||||||
| Alternative sequence | 157 – 1185 | 1029 | Missing in isoform 7. | |||||
| Alternative sequence | 467 – 1185 | 719 | Missing in isoform 6. | |||||
| Alternative sequence | 703 – 727 | 25 | DNFCM…TSYQS → G in isoform 3, isoform 4 and isoform 5. | |||||
| Alternative sequence | 749 – 805 | 57 | Missing in isoform 2 and isoform 4. | |||||
| Alternative sequence | 1006 – 1025 | 20 | SLPSL…LTDMR → RYMVYLLLTDNHNNASKVKW in isoform 5. | |||||
| Alternative sequence | 1026 – 1185 | 160 | Missing in isoform 5. | |||||
Sequences
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain." Groffen A.J.A., Jacobsen L., Schut D., Verhage M. J. Neurochem. 92:554-568(2005) [PubMed: 15659226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY. Strain: 129/Ola. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7). Strain: C57BL/6J. Tissue: Cerebellum, Embryo and Olfactory bulb. |
| [3] | "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588; SER-590; THR-593 AND SER-598, MASS SPECTROMETRY. Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
AY542354 AY542333 Genomic DNA. Translation: AAT68171.1. AY542354 AY542347 Genomic DNA. Translation: AAT68172.1. AY542354 AY542334 Genomic DNA. Translation: AAT68173.1. AY542354 AY542332 Genomic DNA. Translation: AAT68174.1. AY542324 mRNA. Translation: AAT68175.1. AY542325 mRNA. Translation: | |

Clusters with