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Protein

Syntaxin-binding protein 5-like

Gene

Stxbp5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle trafficking and exocytosis.Curated

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central
  • syntaxin binding Source: MGI

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • glucose homeostasis Source: MGI
  • negative regulation of insulin secretion Source: MGI
  • positive regulation of protein secretion Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5-like
Alternative name(s):
Lethal(2) giant larvae protein homolog 4
Tomosyn-2
Gene namesi
Name:Stxbp5l
Synonyms:Llgl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443815. Stxbp5l.

Subcellular locationi

GO - Cellular componenti

  • integral component of membrane Source: InterPro
  • plasma membrane Source: MGI
  • secretory granule Source: GO_Central
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512481 – 1185Syntaxin-binding protein 5-likeAdd BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei567PhosphothreonineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei595PhosphothreonineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei708Omega-N-methylarginineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei1092PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5DQR4.
PeptideAtlasiQ5DQR4.
PRIDEiQ5DQR4.

PTM databases

iPTMnetiQ5DQR4.
PhosphoSitePlusiQ5DQR4.

Expressioni

Tissue specificityi

Detected in hippocampus and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000022829.
CleanExiMM_STXBP5L.

Interactioni

GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central
  • syntaxin binding Source: MGI

Protein-protein interaction databases

IntActiQ5DQR4. 2 interactors.
STRINGi10090.ENSMUSP00000110435.

Structurei

3D structure databases

ProteinModelPortaliQ5DQR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 106WD 1Add BLAST34
Repeati113 – 152WD 2Add BLAST40
Repeati157 – 193WD 3Add BLAST37
Repeati212 – 246WD 4Add BLAST35
Repeati252 – 284WD 5Add BLAST33
Repeati306 – 348WD 6Add BLAST43
Repeati356 – 390WD 7Add BLAST35
Repeati412 – 489WD 8Add BLAST78
Repeati517 – 628WD 9Add BLAST112
Repeati642 – 704WD 10Add BLAST63
Repeati831 – 888WD 11Add BLAST58
Repeati897 – 968WD 12Add BLAST72
Repeati973 – 1017WD 13Add BLAST45
Repeati1031 – 1054WD 14Add BLAST24
Domaini1120 – 1180v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOVERGENiHBG083064.
InParanoidiQ5DQR4.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG091G0LY3.
PhylomeDBiQ5DQR4.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DQR4-1) [UniParc]FASTAAdd to basket
Also known as: Tomosyn-2 isoform xb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ
60 70 80 90 100
ESLTSDYFQI CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG
110 120 130 140 150
VDCYCQHESG AAVLQLQFLI NEGALVSASS DDTLHLWNLR QKRPAILHSL
160 170 180 190 200
KFNRERITYC HLPFQSKWLY VGTERGNTHI VNIESFILSG YVIMWNKAIE
210 220 230 240 250
LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK RAELRVYYDE
260 270 280 290 300
AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK
310 320 330 340 350
SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL
360 370 380 390 400
EMDHPIVEFL TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN
410 420 430 440 450
PYPMDIHESP VTCTAYFADC PPDLILVLYS IGVKHKKQGY SNKEWPVSGG
460 470 480 490 500
AWNLGAQTYP EIIITGHADG TIKFWDASAM TLQMLYKLKT SKVFEKQKAG
510 520 530 540 550
EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY KFSRHEVTTE
560 570 580 590 600
IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG
610 620 630 640 650
VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY
660 670 680 690 700
GIVAFGNCTG LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF
710 720 730 740 750
IADNFCMRGL SNFYPDLTKR IRTSYQSLTE LNDSPVPLEL ERCKSPTSDH
760 770 780 790 800
VNGHCTSPTS QSCSSGKRLS SADVSKVNRW GPGRPPFRKA QSAACMEISL
810 820 830 840 850
PVTTEETREN SYNRSRSSSI SSIDKDSKEA ITALYFMESF ARKNDSTVSP
860 870 880 890 900
CLFVGTSLGM VVLISLNLPS SDEQRFTEPV VVLPSGTFLS LKGAVLTFSC
910 920 930 940 950
MDRTGSLMQP PYEVWRDPNN TDENEKTWKR KLVMNYSSSS QEMGDHQYTI
960 970 980 990 1000
ICSEKQAKVF SLPSQTCLYV HNITETSFIL QADVVVMCNS ACLACFCANG
1010 1020 1030 1040 1050
HIMIMSLPSL RPMLDVNYLP LTDMRIARTF CFTNEGQALY LVSPTEIQRL
1060 1070 1080 1090 1100
TYSQEMCDNI QDMLGDLFTP IETPEAQNRG FLKGLFGGSG QTFDREELFG
1110 1120 1130 1140 1150
EASAGKASRS LAQHIPGPGS IEGMKGAAGG VMGELTRARI ALDERGQRLG
1160 1170 1180
ELEEKTAGMM TSAEAFSKHA HELMLKYKDK KWYQF
Length:1,185
Mass (Da):131,844
Last modified:March 29, 2005 - v1
Checksum:i0F797A5CF20E05DC
GO
Isoform 2 (identifier: Q5DQR4-2) [UniParc]FASTAAdd to basket
Also known as: Tomosyn-2 isoform m

The sequence of this isoform differs from the canonical sequence as follows:
     749-805: Missing.

Show »
Length:1,128
Mass (Da):125,805
Checksum:i47124F194BC9517B
GO
Isoform 3 (identifier: Q5DQR4-3) [UniParc]FASTAAdd to basket
Also known as: Tomosyn-2 isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G

Show »
Length:1,161
Mass (Da):128,906
Checksum:iC5F84EE231D77E22
GO
Isoform 4 (identifier: Q5DQR4-4) [UniParc]FASTAAdd to basket
Also known as: Tomosyn-2 isoform s

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     749-805: Missing.

Show »
Length:1,104
Mass (Da):122,866
Checksum:i433FE26AE29E1903
GO
Isoform 5 (identifier: Q5DQR4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     703-727: DNFCMRGLSNFYPDLTKRIRTSYQS → G
     1006-1025: SLPSLRPMLDVNYLPLTDMR → RYMVYLLLTDNHNNASKVKW
     1026-1185: Missing.

Show »
Length:1,001
Mass (Da):111,411
Checksum:i03E8C91B2C5F16E4
GO
Isoform 6 (identifier: Q5DQR4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-1185: Missing.

Show »
Length:466
Mass (Da):51,948
Checksum:i85DC0F23D3781F2E
GO
Isoform 7 (identifier: Q5DQR4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-1185: Missing.

Show »
Length:156
Mass (Da):16,726
Checksum:i6C22D96E34DFFDB9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016300157 – 1185Missing in isoform 7. 1 PublicationAdd BLAST1029
Alternative sequenceiVSP_016299467 – 1185Missing in isoform 6. 1 PublicationAdd BLAST719
Alternative sequenceiVSP_016295703 – 727DNFCM…TSYQS → G in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_016296749 – 805Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0162971006 – 1025SLPSL…LTDMR → RYMVYLLLTDNHNNASKVKW in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0162981026 – 1185Missing in isoform 5. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542354
, AY542328, AY542329, AY542331, AY542330, AY542332, AY542334, AY542336, AY542338, AY542340, AY542349, AY542348, AY542347, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542337, AY542335, AY542333 Genomic DNA. Translation: AAT68171.1.
AY542354
, AY542328, AY542329, AY542330, AY542332, AY542335, AY542334, AY542333, AY542331, AY542336, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542337, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347 Genomic DNA. Translation: AAT68172.1.
AY542354
, AY542328, AY542329, AY542331, AY542332, AY542330, AY542333, AY542335, AY542337, AY542340, AY542349, AY542348, AY542347, AY542345, AY542338, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542336, AY542334 Genomic DNA. Translation: AAT68173.1.
AY542354
, AY542329, AY542330, AY542328, AY542331, AY542333, AY542335, AY542337, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347, AY542336, AY542334, AY542332 Genomic DNA. Translation: AAT68174.1.
AY542324 mRNA. Translation: AAT68175.1.
AY542325 mRNA. Translation: AAT68176.1.
AY542326 mRNA. Translation: AAT68177.1.
AY542327 mRNA. Translation: AAT68178.1.
AK035159 mRNA. Translation: BAC28964.1.
AK137325 mRNA. Translation: BAE23307.1.
AK161955 mRNA. Translation: BAE36652.1.
CCDSiCCDS28159.2. [Q5DQR4-1]
CCDS49846.1. [Q5DQR4-4]
CCDS49847.1. [Q5DQR4-3]
CCDS49848.1. [Q5DQR4-2]
RefSeqiNP_001108083.1. NM_001114611.1. [Q5DQR4-4]
NP_001108084.1. NM_001114612.1. [Q5DQR4-3]
NP_001108085.1. NM_001114613.1. [Q5DQR4-2]
NP_766028.2. NM_172440.3. [Q5DQR4-1]
UniGeneiMm.403226.
Mm.80170.

Genome annotation databases

EnsembliENSMUST00000023526; ENSMUSP00000023526; ENSMUSG00000022829. [Q5DQR4-5]
ENSMUST00000114775; ENSMUSP00000110423; ENSMUSG00000022829. [Q5DQR4-6]
ENSMUST00000114780; ENSMUSP00000110428; ENSMUSG00000022829. [Q5DQR4-4]
ENSMUST00000114781; ENSMUSP00000110429; ENSMUSG00000022829. [Q5DQR4-2]
ENSMUST00000114782; ENSMUSP00000110430; ENSMUSG00000022829. [Q5DQR4-3]
ENSMUST00000114787; ENSMUSP00000110435; ENSMUSG00000022829. [Q5DQR4-1]
GeneIDi207227.
KEGGimmu:207227.
UCSCiuc007zds.2. mouse. [Q5DQR4-1]
uc007zdt.2. mouse. [Q5DQR4-2]
uc007zdu.2. mouse. [Q5DQR4-3]
uc007zdv.2. mouse. [Q5DQR4-4]
uc007zdw.2. mouse. [Q5DQR4-5]
uc007zdx.2. mouse. [Q5DQR4-6]
uc007zdy.2. mouse. [Q5DQR4-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542354
, AY542328, AY542329, AY542331, AY542330, AY542332, AY542334, AY542336, AY542338, AY542340, AY542349, AY542348, AY542347, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542337, AY542335, AY542333 Genomic DNA. Translation: AAT68171.1.
AY542354
, AY542328, AY542329, AY542330, AY542332, AY542335, AY542334, AY542333, AY542331, AY542336, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542337, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347 Genomic DNA. Translation: AAT68172.1.
AY542354
, AY542328, AY542329, AY542331, AY542332, AY542330, AY542333, AY542335, AY542337, AY542340, AY542349, AY542348, AY542347, AY542345, AY542338, AY542344, AY542343, AY542342, AY542341, AY542353, AY542352, AY542351, AY542350, AY542339, AY542336, AY542334 Genomic DNA. Translation: AAT68173.1.
AY542354
, AY542329, AY542330, AY542328, AY542331, AY542333, AY542335, AY542337, AY542346, AY542345, AY542344, AY542343, AY542342, AY542341, AY542340, AY542339, AY542338, AY542353, AY542352, AY542351, AY542350, AY542349, AY542347, AY542336, AY542334, AY542332 Genomic DNA. Translation: AAT68174.1.
AY542324 mRNA. Translation: AAT68175.1.
AY542325 mRNA. Translation: AAT68176.1.
AY542326 mRNA. Translation: AAT68177.1.
AY542327 mRNA. Translation: AAT68178.1.
AK035159 mRNA. Translation: BAC28964.1.
AK137325 mRNA. Translation: BAE23307.1.
AK161955 mRNA. Translation: BAE36652.1.
CCDSiCCDS28159.2. [Q5DQR4-1]
CCDS49846.1. [Q5DQR4-4]
CCDS49847.1. [Q5DQR4-3]
CCDS49848.1. [Q5DQR4-2]
RefSeqiNP_001108083.1. NM_001114611.1. [Q5DQR4-4]
NP_001108084.1. NM_001114612.1. [Q5DQR4-3]
NP_001108085.1. NM_001114613.1. [Q5DQR4-2]
NP_766028.2. NM_172440.3. [Q5DQR4-1]
UniGeneiMm.403226.
Mm.80170.

3D structure databases

ProteinModelPortaliQ5DQR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5DQR4. 2 interactors.
STRINGi10090.ENSMUSP00000110435.

PTM databases

iPTMnetiQ5DQR4.
PhosphoSitePlusiQ5DQR4.

Proteomic databases

PaxDbiQ5DQR4.
PeptideAtlasiQ5DQR4.
PRIDEiQ5DQR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023526; ENSMUSP00000023526; ENSMUSG00000022829. [Q5DQR4-5]
ENSMUST00000114775; ENSMUSP00000110423; ENSMUSG00000022829. [Q5DQR4-6]
ENSMUST00000114780; ENSMUSP00000110428; ENSMUSG00000022829. [Q5DQR4-4]
ENSMUST00000114781; ENSMUSP00000110429; ENSMUSG00000022829. [Q5DQR4-2]
ENSMUST00000114782; ENSMUSP00000110430; ENSMUSG00000022829. [Q5DQR4-3]
ENSMUST00000114787; ENSMUSP00000110435; ENSMUSG00000022829. [Q5DQR4-1]
GeneIDi207227.
KEGGimmu:207227.
UCSCiuc007zds.2. mouse. [Q5DQR4-1]
uc007zdt.2. mouse. [Q5DQR4-2]
uc007zdu.2. mouse. [Q5DQR4-3]
uc007zdv.2. mouse. [Q5DQR4-4]
uc007zdw.2. mouse. [Q5DQR4-5]
uc007zdx.2. mouse. [Q5DQR4-6]
uc007zdy.2. mouse. [Q5DQR4-7]

Organism-specific databases

CTDi9515.
MGIiMGI:2443815. Stxbp5l.

Phylogenomic databases

eggNOGiENOG410INFH. Eukaryota.
ENOG410XTER. LUCA.
GeneTreeiENSGT00390000000018.
HOVERGENiHBG083064.
InParanoidiQ5DQR4.
KOiK08518.
OMAiMCDNLQE.
OrthoDBiEOG091G0LY3.
PhylomeDBiQ5DQR4.
TreeFamiTF314585.

Miscellaneous databases

PROiQ5DQR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022829.
CleanExiMM_STXBP5L.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTB5L_MOUSE
AccessioniPrimary (citable) accession number: Q5DQR4
Secondary accession number(s): Q3TSM3
, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.