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Q5DNL9

- Q5DNL9_9HIV1

UniProt

Q5DNL9 - Q5DNL9_9HIV1

Protein
Submitted name:

Reverse transcriptase

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. RNA-DNA hybrid ribonuclease activity Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotationImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Reverse transcriptaseImported
    Gene namesi
    Name:polImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Structurei

    3D structure databases

    ProteinModelPortaliQ5DNL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 reverse transcriptase domain.UniRule annotation
    Contains RNase H domain.SAAS annotation
    Contains peptidase Adomain.
    Contains reverse transcriptase domain.SAAS annotation

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    IPR000477. RT_dom.
    IPR010659. RVT_connect.
    IPR010661. RVT_thumb.
    [Graphical view]
    PfamiPF00075. RNase_H. 1 hit.
    PF00078. RVT_1. 1 hit.
    PF06815. RVT_connect. 1 hit.
    PF06817. RVT_thumb. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS50879. RNASE_H. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q5DNL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    PISPIETVPV QLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI    50
    GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKKTQDFWEV QLGIPHPAGL 100
    KKKKSVTVLD VGDAYFSVPL DPDFRKYTAF TIPSINNETP GIRYQYNVLP 150
    QGWKGSPAIF QSSMTKILEP FRKQNPEIVI YQYMDDLYVG SDLEIGQHRT 200
    KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWA VQPIVLPEKD 250
    SWTVNDIQKL VGKLNWASQI YAGIKVRELC KLLRGTKALT EVIPLTEEAE 300
    LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLK 350
    TGKYARMRGA HTNDVKQLTE AVQKIAMESI VIWGKTPKFR LPIQKETWET 400
    WWAEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET 450
    KLGKAGYVTD KGRQKVVSLT DTTNQKTELQ AIHLALQDSG SEVNIVTDSQ 500
    YALGIIQAQP DKSESELVNQ IIEQLINKEK VYLAWVPAHK GIGGNEQVDK 550
    LVSTGIRKVL 560
    Length:560
    Mass (Da):64,299
    Last modified:March 29, 2005 - v1
    Checksum:iADF0EB05EA4B45FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei560 – 5601Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY560468 Genomic DNA. Translation: AAT66854.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY560468 Genomic DNA. Translation: AAT66854.1 .

    3D structure databases

    ProteinModelPortali Q5DNL9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    IPR000477. RT_dom.
    IPR010659. RVT_connect.
    IPR010661. RVT_thumb.
    [Graphical view ]
    Pfami PF00075. RNase_H. 1 hit.
    PF00078. RVT_1. 1 hit.
    PF06815. RVT_connect. 1 hit.
    PF06817. RVT_thumb. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS50879. RNASE_H. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic Characterization of HIV Type 1 Reverse Transcriptase Gene From Mothers and Infants Following Perinatal Transmission."
      Sundaravaradan V., Hahn T., Ahmad N.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ5DNL9_9HIV1
    AccessioniPrimary (citable) accession number: Q5DNL9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)