Reverse transcriptase - Human immunodeficiency virus 1

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Q5DNL9 (Q5DNL9_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified January 9, 2013. Version 53. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Reverse transcriptase EMBL AAT66854.1

Gene names

Name:

pol EMBL AAT66854.1

Organism

Human immunodeficiency virus 1 EMBL AAT66854.1

Taxonomic identifier

11676 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	560 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. SAAS SAAS002156

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS000477

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. SAAS SAAS002156

Sequence similarities

Contains 1 RNase H domain.

Contains 1 peptidase A2 domain. SAAS SAAS010659

Contains 1 reverse transcriptase domain. SAAS SAAS002156 RuleBase RU000322

Ontologies

Keywords
Biological process	DNA integration SAAS SAAS010659 DNA recombination SAAS SAAS010659
Molecular function	Aspartyl protease SAAS SAAS010659 Endonuclease SAAS SAAS000477 Hydrolase Nuclease Nucleotidyltransferase Protease RNA-directed DNA polymerase SAAS SAAS000477 EMBL AAT66854.1 Transferase
Technical term	Multifunctional enzyme SAAS SAAS010659
Gene Ontology (GO)
Biological_process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL AAT66854.1

Non-terminal residue

560

EMBL AAT66854.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q5DNL9 [UniParc].

Last modified March 29, 2005. Version 1.
Checksum: ADF0EB05EA4B45FD
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FASTA

560

64,299

        10         20         30         40         50         60 
PISPIETVPV QLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI GPENPYNTPV 

        70         80         90        100        110        120 
FAIKKKDSTK WRKLVDFREL NKKTQDFWEV QLGIPHPAGL KKKKSVTVLD VGDAYFSVPL 

       130        140        150        160        170        180 
DPDFRKYTAF TIPSINNETP GIRYQYNVLP QGWKGSPAIF QSSMTKILEP FRKQNPEIVI 

       190        200        210        220        230        240 
YQYMDDLYVG SDLEIGQHRT KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWA 

       250        260        270        280        290        300 
VQPIVLPEKD SWTVNDIQKL VGKLNWASQI YAGIKVRELC KLLRGTKALT EVIPLTEEAE 

       310        320        330        340        350        360 
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLK TGKYARMRGA 

       370        380        390        400        410        420 
HTNDVKQLTE AVQKIAMESI VIWGKTPKFR LPIQKETWET WWAEYWQATW IPEWEFVNTP 

       430        440        450        460        470        480 
PLVKLWYQLE KEPIVGAETF YVDGAANRET KLGKAGYVTD KGRQKVVSLT DTTNQKTELQ 

       490        500        510        520        530        540 
AIHLALQDSG SEVNIVTDSQ YALGIIQAQP DKSESELVNQ IIEQLINKEK VYLAWVPAHK 

       550        560 
GIGGNEQVDK LVSTGIRKVL

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References

[1]	"Genetic Characterization of HIV Type 1 Reverse Transcriptase Gene From Mothers and Infants Following Perinatal Transmission." Sundaravaradan V., Hahn T., Ahmad N. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY560468 Genomic DNA. Translation: AAT66854.1.
3D structure databases
ProteinModelPortal	Q5DNL9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012337. RNaseH-like_dom. IPR002156. RNaseH_domain. IPR000477. RVT. IPR010659. RVT_connect. IPR010661. RVT_thumb. [Graphical view]
Pfam	PF00075. RNase_H. 1 hit. PF00078. RVT_1. 1 hit. PF06815. RVT_connect. 1 hit. PF06817. RVT_thumb. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS50879. RNASE_H. 1 hit. PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5DNL9_9HIV1

Accession

Primary (citable) accession number: Q5DNL9

Entry history

Integrated into UniProtKB/TrEMBL:	March 29, 2005
Last sequence update:	March 29, 2005
Last modified:	January 9, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

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