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Q5DNL9

- Q5DNL9_9HIV1

UniProt

Q5DNL9 - Q5DNL9_9HIV1

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Protein
Submitted name:

Reverse transcriptase

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. RNA-DNA hybrid ribonuclease activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Reverse transcriptaseImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliQ5DNL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains RNase H domain.SAAS annotation
Contains reverse transcriptase domain.SAAS annotation

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5DNL9-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
PISPIETVPV QLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI
60 70 80 90 100
GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKKTQDFWEV QLGIPHPAGL
110 120 130 140 150
KKKKSVTVLD VGDAYFSVPL DPDFRKYTAF TIPSINNETP GIRYQYNVLP
160 170 180 190 200
QGWKGSPAIF QSSMTKILEP FRKQNPEIVI YQYMDDLYVG SDLEIGQHRT
210 220 230 240 250
KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWA VQPIVLPEKD
260 270 280 290 300
SWTVNDIQKL VGKLNWASQI YAGIKVRELC KLLRGTKALT EVIPLTEEAE
310 320 330 340 350
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLK
360 370 380 390 400
TGKYARMRGA HTNDVKQLTE AVQKIAMESI VIWGKTPKFR LPIQKETWET
410 420 430 440 450
WWAEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET
460 470 480 490 500
KLGKAGYVTD KGRQKVVSLT DTTNQKTELQ AIHLALQDSG SEVNIVTDSQ
510 520 530 540 550
YALGIIQAQP DKSESELVNQ IIEQLINKEK VYLAWVPAHK GIGGNEQVDK
560
LVSTGIRKVL
Length:560
Mass (Da):64,299
Last modified:March 29, 2005 - v1
Checksum:iADF0EB05EA4B45FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei560 – 5601Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY560468 Genomic DNA. Translation: AAT66854.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY560468 Genomic DNA. Translation: AAT66854.1 .

3D structure databases

ProteinModelPortali Q5DNL9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic Characterization of HIV Type 1 Reverse Transcriptase Gene From Mothers and Infants Following Perinatal Transmission."
    Sundaravaradan V., Hahn T., Ahmad N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5DNL9_9HIV1
AccessioniPrimary (citable) accession number: Q5DNL9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)