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Q5DNL9

- Q5DNL9_9HIV1

UniProt

Q5DNL9 - Q5DNL9_9HIV1

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Protein
Submitted name: Reverse transcriptase
Gene
pol
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotations

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: InterPro
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotationsImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Reverse transcriptaseImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliQ5DNL9.

Family & Domainsi

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains RNase H domain.SAAS annotations
Contains peptidase Adomain.
Contains reverse transcriptase domain.SAAS annotations

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5DNL9-1 [UniParc]FASTAAdd to Basket

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PISPIETVPV QLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI    50
GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKKTQDFWEV QLGIPHPAGL 100
KKKKSVTVLD VGDAYFSVPL DPDFRKYTAF TIPSINNETP GIRYQYNVLP 150
QGWKGSPAIF QSSMTKILEP FRKQNPEIVI YQYMDDLYVG SDLEIGQHRT 200
KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWA VQPIVLPEKD 250
SWTVNDIQKL VGKLNWASQI YAGIKVRELC KLLRGTKALT EVIPLTEEAE 300
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLK 350
TGKYARMRGA HTNDVKQLTE AVQKIAMESI VIWGKTPKFR LPIQKETWET 400
WWAEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET 450
KLGKAGYVTD KGRQKVVSLT DTTNQKTELQ AIHLALQDSG SEVNIVTDSQ 500
YALGIIQAQP DKSESELVNQ IIEQLINKEK VYLAWVPAHK GIGGNEQVDK 550
LVSTGIRKVL 560
Length:560
Mass (Da):64,299
Last modified:March 29, 2005 - v1
Checksum:iADF0EB05EA4B45FD
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei560 – 5601Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY560468 Genomic DNA. Translation: AAT66854.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY560468 Genomic DNA. Translation: AAT66854.1 .

3D structure databases

ProteinModelPortali Q5DNL9.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic Characterization of HIV Type 1 Reverse Transcriptase Gene From Mothers and Infants Following Perinatal Transmission."
    Sundaravaradan V., Hahn T., Ahmad N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5DNL9_9HIV1
AccessioniPrimary (citable) accession number: Q5DNL9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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