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Q5DL24

- Q5DL24_9INFA

UniProt

Q5DL24 - Q5DL24_9INFA

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Protein
Submitted name:

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/black-headed gull/Sweden/2/99(H16N3))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotationSAAS annotation

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotation

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/black-headed gull/Sweden/2/99(H16N3))Imported
Taxonomic identifieri304362 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi181 – 1811N-linked (GlcNAc...)Imported
Glycosylationi495 – 4951N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F23X-ray1.70A/B/C19-517[»]
4FIUX-ray2.00A/B/C19-517[»]
ProteinModelPortaliQ5DL24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5DL24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTLYLLVL IFVKYSRADK ICIGYLSNNS TDTVDTLTEN GVPVTSSIDL
60 70 80 90 100
VETNHTGTYC SLNGVSPIHL GDCSFEGWIV GNPSCASNIN IREWSYLIED
110 120 130 140 150
PNAPHKLCFP GEVDNNGELR HLFSGVNSFS RTELIPPSKW GDILEGTTAS
160 170 180 190 200
CQNRGANSFY RNLIWLVNKL NKYPVVKGEY NNTTGRDVLV LWGIHHPDTE
210 220 230 240 250
ATANKLYVNK NPYTLVSTKE WSRRYELEIG TRIGDGQRSW MKIYWHLMHP
260 270 280 290 300
GERITFESSG GLLAPRYGYI IEKYGTGRIF QSGVRLAKCN TKCQTSMGGI
310 320 330 340 350
NTNKTFQNIE RNALGDCPKY IKSGQLKLAT GLRNVPSIVE RGLFGAIAGF
360 370 380 390 400
IEGGWPGLIN GWYGFQHQNE QGTGIAADKT STQKAINEIT TKINNIIEKM
410 420 430 440 450
NGNYDSIRGE FNQVEKRINM IADRVDDAVT DIWSYNAKLL VLIENDRTLD
460 470 480 490 500
LHDANVRNLH EQIKRALKDN AIDEGDGCFS ILHKCNDSCM ETIRNGTYNH
510 520 530 540 550
EDYKEESQLK RQEIEGIKLK TEDNVYKILS IYSCIASSVV LVGLILAFIL
560
WACSSGNCRF NVCI
Length:564
Mass (Da):63,266
Last modified:March 29, 2005 - v1
Checksum:i24ECBDF6D2233971
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684888 Genomic RNA. Translation: AAV91214.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY684888 Genomic RNA. Translation: AAV91214.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4F23 X-ray 1.70 A/B/C 19-517 [» ]
4FIU X-ray 2.00 A/B/C 19-517 [» ]
ProteinModelPortali Q5DL24.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/black-headed gull/Sweden/2/99Imported.
  2. "Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls."
    Fouchier R.A., Munster V., Wallensten A., Bestebroer T.M., Herfst S., Smith D., Rimmelzwaan G.F., Olsen B., Osterhaus A.D.
    J. Virol. 79:2814-2822(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/black-headed gull/Sweden/2/99Imported.
  3. "Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of subtype H16 has an alpha-helix structure in its cleavage site with inefficient HA1/HA2 cleavage."
    Lu X., Shi Y., Gao F., Xiao H., Wang M., Qi J., Gao G.F.
    J. Virol. 86:12861-12870(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 19-517, GLYCOSYLATION AT ASN-181 AND ASN-495.

Entry informationi

Entry nameiQ5DL24_9INFA
AccessioniPrimary (citable) accession number: Q5DL24
Entry historyi
Integrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3