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Protein

Inactive hyaluronidase B

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has no hyaluronidase activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive hyaluronidase B
Short name:
Hya B
Alternative name(s):
Hyaluronoglucosaminidase B
Allergen: Ves v 2b
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.Curated

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3522. Ves v 2.0201.
669. Ves v 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Inactive hyaluronidase BPRO_0000271764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 310By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)1 Publication
Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
Disulfide bondi187 ↔ 199By similarity

Post-translational modificationi

N-glycosylated on at least two Asn residues by identical heptasaccharide units composed of Man, GlcNAc, and Fuc residues in the molar ration of 3:2:2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5D7H4.
SMRiQ5D7H4. Positions 8-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Sequence analysis

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5D7H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DRTIWPKKGF SIYWNIPTHF CHNFGVYFKE LKQFNIKYNS MNNFRGETIS
60 70 80 90 100
LFYDPGNFPS MVLLKNGTYE IRNEGVPQKG NLTIHLEQFT KELDEIYPKK
110 120 130 140 150
IAGGIGVIHF HNWRPIFRRN VDNLKINKDI SIDLVRKEHP KWDKSMIEKE
160 170 180 190 200
ASNRFETSAK IFMEKTLKLA KEIRKKTEWG YHGYPHCLSG STDKPSFDCD
210 220 230 240 250
ALSMSENDKM SWLFNNQNVL LPSIYLKNVL KPDEKIHLVQ ERLKEAIRIS
260 270 280 290 300
KNFKHLPKVL PYWWYTYQDK ESIFLTEADV KNTFKEILTN GADGIIIWGV
310 320 330 340
SYELTDRKRC EKLKEYLMKI LGPIAFKVTK AVKENTPLNF
Length:340
Mass (Da):40,072
Last modified:March 29, 2005 - v1
Checksum:i9E922056BCFC1CA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101F → S AA sequence (PubMed:16218950).Curated
Sequence conflicti273 – 2731I → L AA sequence (PubMed:16218950).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845866 mRNA. Translation: AAX14718.1.
AJ920395 mRNA. Translation: CAI77218.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845866 mRNA. Translation: AAX14718.1.
AJ920395 mRNA. Translation: CAI77218.1.

3D structure databases

ProteinModelPortaliQ5D7H4.
SMRiQ5D7H4. Positions 8-331.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3522. Ves v 2.0201.
669. Ves v 2.
CAZyiGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUGAB_VESVU
AccessioniPrimary (citable) accession number: Q5D7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 29, 2005
Last modified: October 14, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Lacks the typical Glu active site in position 111 that is replaced by a His residue, preventing the hyaluronidase activity.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.