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Protein
Submitted name:

Crossveinless 2

Gene

bmper

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • extracellular matrix binding Source: ZFIN

GO - Biological processi

  • blood vessel development Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • endothelial cell differentiation Source: InterPro
  • hemopoiesis Source: ZFIN
  • negative regulation of BMP signaling pathway Source: InterPro
  • neural crest formation Source: ZFIN
  • otic placode formation Source: ZFIN
  • regulation of angiogenesis Source: ZFIN
  • regulation of BMP signaling pathway Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Crossveinless 2Imported
Gene namesi
Name:bmperImported
Synonyms:cvl2Imported, id:ibd5071Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030219-146. bmper.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ZFIN
  • proteinaceous extracellular matrix Source: ZFIN
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 668641Sequence analysisPRO_5004254795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 58Combined sources
Disulfide bondi53 ↔ 87Combined sources
Disulfide bondi56 ↔ 65Combined sources
Disulfide bondi70 ↔ 88Combined sources
Disulfide bondi77 ↔ 91Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MBKNMR-A28-93[»]
3BK3X-ray2.70C/D28-93[»]
ProteinModelPortaliQ5D734.
SMRiQ5D734. Positions 28-93.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5D734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 21162VWFCInterPro annotationAdd
BLAST
Domaini283 – 34260VWFCInterPro annotationAdd
BLAST
Domaini347 – 546200VWFDInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000234284.
HOVERGENiHBG050704.
PhylomeDBiQ5D734.

Family and domain databases

InterProiIPR030120. Bmper.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF272. PTHR11339:SF272. 1 hit.
PfamiPF01826. TIL. 1 hit.
PF00093. VWC. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5D734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLSPPVTY NLLFWFLILQ TPQSTAPLIT GTEASCENEG EVLHIPNITD
60 70 80 90 100
NPCISCVCLN QKAECKQEKC APLAEDCALV VKQTGACCEK CKGCLLKGTS
110 120 130 140 150
YNSSHHWISP VKPCVTYSCQ EGVITEAEMR CVIHCKNPKI HPKKCCPTCP
160 170 180 190 200
GCIFEGIYIK KMKNFTLKGN PCIKCVCTGG QSMCHNWCVL FCPARLIFTH
210 220 230 240 250
TPPGQCCPRC RGQRRVFDLS PGSCLFHSEV YENGSSISYD NCTTCTCVDS
260 270 280 290 300
TVLCRKRCSP PGSCHGTACC EACQSLLKME DVKYCRVKSK IYRDGDRWSS
310 320 330 340 350
VNCSLCTCVK GNIQCQPKIC VPITSCPSNK ILNRTGCCPV CTDKPGVCTV
360 370 380 390 400
FGDPHYNTFD GRTFNFQGTC KYVLTKDCSP AASFTVLVKN DARRTRSFSW
410 420 430 440 450
TKSVELHTSG LSISLHQHLT VRQNGTRIAL PFHSTGVHID LDGYLLKLTT
460 470 480 490 500
IAGLEITWDG DSLVEVVAAP HLKGQLCGLC GNYNGQRRDD SLGGDGQFKF
510 520 530 540 550
DVDELAESWR VEDNELCEVQ NRRPTSFLCA GTVKVKLRAH RTCQKLKSWG
560 570 580 590 600
VSEVPSAVDF TSFYKSCVTD MCECPVHKNC FCESFIAYSR AREREGIHVH
610 620 630 640 650
WRPELTCMST HCKHGAVYDT CGPGCTKSCH NWNEIGPCQR PCIAGCHCPA
660
SLVMFQGHCI KPTSCPGR
Length:668
Mass (Da):73,807
Last modified:March 29, 2005 - v1
Checksum:i7161F8E5477A513E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY847871 mRNA. Translation: AAX14720.1.
UniGeneiDr.38460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY847871 mRNA. Translation: AAX14720.1.
UniGeneiDr.38460.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MBKNMR-A28-93[»]
3BK3X-ray2.70C/D28-93[»]
ProteinModelPortaliQ5D734.
SMRiQ5D734. Positions 28-93.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-030219-146. bmper.

Phylogenomic databases

HOGENOMiHOG000234284.
HOVERGENiHBG050704.
PhylomeDBiQ5D734.

Miscellaneous databases

EvolutionaryTraceiQ5D734.
NextBioi20812596.

Family and domain databases

InterProiIPR030120. Bmper.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF272. PTHR11339:SF272. 1 hit.
PfamiPF01826. TIL. 1 hit.
PF00093. VWC. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation."
    Rentzsch F., Zhang J., Kramer C., Sebald W., Hammerschmidt M.
    Development 133:801-811(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding."
    Zhang J.L., Qiu L.Y., Kotzsch A., Weidauer S., Patterson L., Hammerschmidt M., Sebald W., Mueller T.D.
    Dev. Cell 14:739-750(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 28-93, DISULFIDE BONDS.
  3. "The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed."
    Fiebig J.E., Weidauer S.E., Qiu L.Y., Bauer M., Schmieder P., Beerbaum M., Zhang J.L., Oschkinat H., Sebald W., Mueller T.D.
    Molecules 18:11658-11682(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 28-93, DISULFIDE BONDS.

Entry informationi

Entry nameiQ5D734_DANRE
AccessioniPrimary (citable) accession number: Q5D734
Entry historyi
Integrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.