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Protein

Cholecystokinin receptor type A

Gene

CCKAR

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:CCKAR
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 67Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 115ExtracellularSequence analysisAdd BLAST11
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 157CytoplasmicSequence analysisAdd BLAST20
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 210ExtracellularSequence analysisAdd BLAST32
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 313CytoplasmicSequence analysisAdd BLAST79
Transmembranei314 – 334Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini335 – 349ExtracellularSequence analysisAdd BLAST15
Transmembranei350 – 373Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini374 – 428CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002473141 – 428Cholecystokinin receptor type AAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Lipidationi387S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ5D0K2.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000036103.

Structurei

3D structure databases

ProteinModelPortaliQ5D0K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiQ5D0K2.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
TreeFamiTF315303.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5D0K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVADSLLGN GSDVPPPCEL GLENETLVCL EQPRAAKEWQ PAVQILLYSL
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR
160 170 180 190 200
VWQTKSHALK VIATTWCLSF TIMTPYPIYS NLVPFTKTNN QTANMCRFLL
210 220 230 240 250
PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFDAIQKKSA
260 270 280 290 300
RDRNPSTGSS GRYEDGDGCY LQKARPRRRL ELRQLSTPGS GRLNRIRSTS
310 320 330 340 350
STANLMAKKR VIRMLMVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT
360 370 380 390 400
PISFILLLSY TSSCVNPIIY CFMNKRFRLG FLATFPCCPH PGPPGPRGEV
410 420
GEEEEGRTTG ASLSRYSYSH MSASAPGP
Length:428
Mass (Da):47,836
Last modified:March 29, 2005 - v1
Checksum:iED61C36912549D52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY934643 mRNA. Translation: AAX12114.1.
RefSeqiNP_001012664.1. NM_001012646.2.
UniGeneiCfa.16333.

Genome annotation databases

EnsembliENSCAFT00000045520; ENSCAFP00000036103; ENSCAFG00000029430.
GeneIDi488846.
KEGGicfa:488846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY934643 mRNA. Translation: AAX12114.1.
RefSeqiNP_001012664.1. NM_001012646.2.
UniGeneiCfa.16333.

3D structure databases

ProteinModelPortaliQ5D0K2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000036103.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5D0K2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000045520; ENSCAFP00000036103; ENSCAFG00000029430.
GeneIDi488846.
KEGGicfa:488846.

Organism-specific databases

CTDi886.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiQ5D0K2.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKAR_CANLF
AccessioniPrimary (citable) accession number: Q5D0K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 29, 2005
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.