Q5D0E6 (DALD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DALR anticodon-binding domain-containing protein 3

Gene names

Name:

DALRD3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro arginine-tRNA ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5D0E6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5D0E6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     444-543: GEWLLLFNSI...MLGLPPLSHI → YPPLSGSAEP...RPPAASESCA

Isoform 3 (identifier: Q5D0E6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     133-138: RLSQLR → TGCACA
     139-543: Missing.

Isoform 4 (identifier: Q5D0E6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 543	543	DALR anticodon-binding domain-containing protein 3		PRO_0000315848
Natural variations
	Alternative sequence	1 – 167	167	Missing in isoform 4.		VSP_030741
	Alternative sequence	133 – 138	6	RLSQLR → TGCACA in isoform 3.		VSP_030743
	Alternative sequence	139 – 543	405	Missing in isoform 3.		VSP_030744
	Alternative sequence	444 – 543	100	GEWLL…PLSHI → YPPLSGSAEPDSSAGLHSPG APHCCTHRDDMQVPGTAQHG FQLLLQPGTHPGGASTTPLW SDVRPPAASESCA in isoform 2.		VSP_030746
	Natural variant	299	1	Q → R. Ref.1 Ref.3 Corresponds to variant rs3087866 [ dbSNP | Ensembl ].		VAR_038349
Experimental info
	Sequence conflict	27	1	I → T in BAA91647. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 78AFBA859D0E074B	FASTA	543	59,363
	10 20 30 40 50 60 MATRRLGVGE TLGALNAALG PGGPVWIKET RTRHLRSRDF LAPHRALQAR FDDGQVPEHL 70 80 90 100 110 120 LHALACLQGP GVAPVLRCAP TPAGLSLQLQ RSAVFERVLS AVAAYATPAS PASLGQRVLL 130 140 150 160 170 180 HCPALRSSPC ALRLSQLRTV LVADHLARAL RAHGVCVRLV PAVRDPHMLT FLQQLRVDWP 190 200 210 220 230 240 AASERASSHT LRSHALEELT SANDGRTLSP GILGRLCLKE LVEEQGRTAG YDPNLDNCLV 250 260 270 280 290 300 TEDLLSVLAE LQEALWHWPE DSHPGLAGAS DTGTGGCLVV HVVSCEEEFQ QQKLDLLWQK 310 320 330 340 350 360 LVDKAPLRQK HLICGPVKVA GAPGTLMTAP EYYEFRHTQV CKASALKHGG DLAQDPAWTE 370 380 390 400 410 420 IFGVLSVATI KFEMLSTAPQ SQLFLALADS SISTKGTKSG TFVMYNCARL ATLFESYKCS 430 440 450 460 470 480 MEQGLYPTFP PVSSLDFSLL HDEGEWLLLF NSILPFPDLL SRTAVLDCTA PGLHIAVRTE 490 500 510 520 530 540 MICKFLVQLS MDFSSYYNRV HILGEPRPHL FGQMFVRLQL LRAVREVLHT GLAMLGLPPL SHI
	Isoform 2 [UniParc]. Checksum: BB3C375E2DB6196C	FASTA	516	55,453
	10 20 30 40 50 60 MATRRLGVGE TLGALNAALG PGGPVWIKET RTRHLRSRDF LAPHRALQAR FDDGQVPEHL 70 80 90 100 110 120 LHALACLQGP GVAPVLRCAP TPAGLSLQLQ RSAVFERVLS AVAAYATPAS PASLGQRVLL 130 140 150 160 170 180 HCPALRSSPC ALRLSQLRTV LVADHLARAL RAHGVCVRLV PAVRDPHMLT FLQQLRVDWP 190 200 210 220 230 240 AASERASSHT LRSHALEELT SANDGRTLSP GILGRLCLKE LVEEQGRTAG YDPNLDNCLV 250 260 270 280 290 300 TEDLLSVLAE LQEALWHWPE DSHPGLAGAS DTGTGGCLVV HVVSCEEEFQ QQKLDLLWQK 310 320 330 340 350 360 LVDKAPLRQK HLICGPVKVA GAPGTLMTAP EYYEFRHTQV CKASALKHGG DLAQDPAWTE 370 380 390 400 410 420 IFGVLSVATI KFEMLSTAPQ SQLFLALADS SISTKGTKSG TFVMYNCARL ATLFESYKCS 430 440 450 460 470 480 MEQGLYPTFP PVSSLDFSLL HDEYPPLSGS AEPDSSAGLH SPGAPHCCTH RDDMQVPGTA 490 500 510 QHGFQLLLQP GTHPGGASTT PLWSDVRPPA ASESCA
	Isoform 3 [UniParc]. Checksum: B6E76E24E397A7E9	FASTA	138	14,419
	10 20 30 40 50 60 MATRRLGVGE TLGALNAALG PGGPVWIKET RTRHLRSRDF LAPHRALQAR FDDGQVPEHL 70 80 90 100 110 120 LHALACLQGP GVAPVLRCAP TPAGLSLQLQ RSAVFERVLS AVAAYATPAS PASLGQRVLL 130 HCPALRSSPC ALTGCACA
	Isoform 4 [UniParc]. Checksum: F0812124BD2BC042	FASTA	376	41,590
	10 20 30 40 50 60 MLTFLQQLRV DWPAASERAS SHTLRSHALE ELTSANDGRT LSPGILGRLC LKELVEEQGR 70 80 90 100 110 120 TAGYDPNLDN CLVTEDLLSV LAELQEALWH WPEDSHPGLA GASDTGTGGC LVVHVVSCEE 130 140 150 160 170 180 EFQQQKLDLL WQKLVDKAPL RQKHLICGPV KVAGAPGTLM TAPEYYEFRH TQVCKASALK 190 200 210 220 230 240 HGGDLAQDPA WTEIFGVLSV ATIKFEMLST APQSQLFLAL ADSSISTKGT KSGTFVMYNC 250 260 270 280 290 300 ARLATLFESY KCSMEQGLYP TFPPVSSLDF SLLHDEGEWL LLFNSILPFP DLLSRTAVLD 310 320 330 340 350 360 CTAPGLHIAV RTEMICKFLV QLSMDFSSYY NRVHILGEPR PHLFGQMFVR LQLLRAVREV 370 LHTGLAMLGL PPLSHI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT ARG-299. Tissue: Testis.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-299. Tissue: Blood and Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001358 mRNA. Translation: BAA91647.1. AK093204 mRNA. Translation: BAC04095.1. AK093294 mRNA. Translation: BAC04123.1. AC137630 Genomic DNA. No translation available. BC032440 mRNA. Translation: AAH32440.2. BC047683 mRNA. Translation: AAH47683.1. BC054493 mRNA. Translation: AAH54493.1.
IPI	IPI00329164. IPI00385311. IPI00645243. IPI00796826.
RefSeq	NP_001009996.1. NM_001009996.2. NP_001263334.1. NM_001276405.1. NP_060584.3. NM_018114.5.
UniGene	Hs.654815. Hs.708076.
3D structure databases
ProteinModelPortal	Q5D0E6.
SMR	Q5D0E6. Positions 110-167.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5D0E6. 1 interaction.
STRING	9606.ENSP00000344989.
PTM databases
PhosphoSite	Q5D0E6.
Polymorphism databases
DMDM	296434472.
Proteomic databases
PaxDb	Q5D0E6.
PRIDE	Q5D0E6.
Protocols and materials databases
DNASU	55152.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313778; ENSP00000323265; ENSG00000178149. ENST00000341949; ENSP00000344989; ENSG00000178149. ENST00000395462; ENSP00000378846; ENSG00000178149. ENST00000441576; ENSP00000410623; ENSG00000178149.
GeneID	55152.
KEGG	hsa:55152.
UCSC	uc003cvk.1. human. uc003cvl.1. human.
Organism-specific databases
CTD	55152.
GeneCards	GC03M049066.
HGNC	HGNC:25536. DALRD3.
HPA	HPA036862.
neXtProt	NX_Q5D0E6.
PharmGKB	PA134921814.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147399.
HOGENOM	HOG000043068.
HOVERGEN	HBG106219.
InParanoid	Q5D0E6.
OMA	AQVCKAS.
OrthoDB	EOG4B2SWZ.
PhylomeDB	Q5D0E6.
Gene expression databases
ArrayExpress	Q5D0E6.
Bgee	Q5D0E6.
CleanEx	HS_DALRD3.
Genevestigator	Q5D0E6.
Family and domain databases
InterPro	IPR008909. DALR_anticod-bd. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Pfam	PF05746. DALR_1. 1 hit. [Graphical view]
SMART	SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF47323. tRNAsyn_1a_bind. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55152.
NextBio	58887.

Entry information

Entry name

DALD3_HUMAN

Accession

Primary (citable) accession number: Q5D0E6
Secondary accession number(s): Q7Z5S7 , Q86WY1, Q8N105, Q8NA89, Q9NVU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.