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Protein

DALR anticodon-binding domain-containing protein 3

Gene

DALRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DALR anticodon-binding domain-containing protein 3
Gene namesi
Name:DALRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25536. DALRD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921814.

Polymorphism and mutation databases

DMDMi296434472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543DALR anticodon-binding domain-containing protein 3PRO_0000315848Add
BLAST

Proteomic databases

MaxQBiQ5D0E6.
PaxDbiQ5D0E6.
PRIDEiQ5D0E6.

PTM databases

iPTMnetiQ5D0E6.
PhosphoSiteiQ5D0E6.

Expressioni

Gene expression databases

BgeeiQ5D0E6.
CleanExiHS_DALRD3.
ExpressionAtlasiQ5D0E6. baseline and differential.
GenevisibleiQ5D0E6. HS.

Organism-specific databases

HPAiHPA036862.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP619783EBI-2871865,EBI-304185

Protein-protein interaction databases

BioGridi120455. 6 interactions.
IntActiQ5D0E6. 6 interactions.
MINTiMINT-6775473.
STRINGi9606.ENSP00000344989.

Structurei

3D structure databases

ProteinModelPortaliQ5D0E6.
SMRiQ5D0E6. Positions 115-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
GeneTreeiENSGT00390000014621.
HOGENOMiHOG000043068.
HOVERGENiHBG106219.
InParanoidiQ5D0E6.
OMAiAQVCKAS.
OrthoDBiEOG75MVVR.
PhylomeDBiQ5D0E6.
TreeFamiTF325601.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
InterProiIPR008909. DALR_anticod-bd.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF05746. DALR_1. 1 hit.
[Graphical view]
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5D0E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRRLGVGE TLGALNAALG PGGPVWIKET RTRHLRSRDF LAPHRALQAR
60 70 80 90 100
FDDGQVPEHL LHALACLQGP GVAPVLRCAP TPAGLSLQLQ RSAVFERVLS
110 120 130 140 150
AVAAYATPAS PASLGQRVLL HCPALRSSPC ALRLSQLRTV LVADHLARAL
160 170 180 190 200
RAHGVCVRLV PAVRDPHMLT FLQQLRVDWP AASERASSHT LRSHALEELT
210 220 230 240 250
SANDGRTLSP GILGRLCLKE LVEEQGRTAG YDPNLDNCLV TEDLLSVLAE
260 270 280 290 300
LQEALWHWPE DSHPGLAGAS DTGTGGCLVV HVVSCEEEFQ QQKLDLLWQK
310 320 330 340 350
LVDKAPLRQK HLICGPVKVA GAPGTLMTAP EYYEFRHTQV CKASALKHGG
360 370 380 390 400
DLAQDPAWTE IFGVLSVATI KFEMLSTAPQ SQLFLALADS SISTKGTKSG
410 420 430 440 450
TFVMYNCARL ATLFESYKCS MEQGLYPTFP PVSSLDFSLL HDEGEWLLLF
460 470 480 490 500
NSILPFPDLL SRTAVLDCTA PGLHIAVRTE MICKFLVQLS MDFSSYYNRV
510 520 530 540
HILGEPRPHL FGQMFVRLQL LRAVREVLHT GLAMLGLPPL SHI
Length:543
Mass (Da):59,363
Last modified:May 18, 2010 - v2
Checksum:i78AFBA859D0E074B
GO
Isoform 2 (identifier: Q5D0E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-543: GEWLLLFNSI...MLGLPPLSHI → YPPLSGSAEP...RPPAASESCA

Show »
Length:516
Mass (Da):55,453
Checksum:iBB3C375E2DB6196C
GO
Isoform 3 (identifier: Q5D0E6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-138: RLSQLR → TGCACA
     139-543: Missing.

Show »
Length:138
Mass (Da):14,419
Checksum:iB6E76E24E397A7E9
GO
Isoform 4 (identifier: Q5D0E6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:376
Mass (Da):41,590
Checksum:iF0812124BD2BC042
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271I → T in BAA91647 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991Q → R.2 Publications
Corresponds to variant rs3087866 [ dbSNP | Ensembl ].
VAR_038349

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 167167Missing in isoform 4. 1 PublicationVSP_030741Add
BLAST
Alternative sequencei133 – 1386RLSQLR → TGCACA in isoform 3. 1 PublicationVSP_030743
Alternative sequencei139 – 543405Missing in isoform 3. 1 PublicationVSP_030744Add
BLAST
Alternative sequencei444 – 543100GEWLL…PLSHI → YPPLSGSAEPDSSAGLHSPG APHCCTHRDDMQVPGTAQHG FQLLLQPGTHPGGASTTPLW SDVRPPAASESCA in isoform 2. 1 PublicationVSP_030746Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001358 mRNA. Translation: BAA91647.1.
AK093204 mRNA. Translation: BAC04095.1.
AK093294 mRNA. Translation: BAC04123.1.
AC137630 Genomic DNA. No translation available.
BC032440 mRNA. Translation: AAH32440.2.
BC047683 mRNA. Translation: AAH47683.1.
BC054493 mRNA. Translation: AAH54493.1.
CCDSiCCDS2783.1. [Q5D0E6-4]
CCDS33754.1. [Q5D0E6-1]
CCDS63632.1. [Q5D0E6-2]
RefSeqiNP_001009996.1. NM_001009996.2. [Q5D0E6-1]
NP_001263334.1. NM_001276405.1. [Q5D0E6-2]
NP_060584.3. NM_018114.5. [Q5D0E6-4]
UniGeneiHs.654815.
Hs.708076.
Hs.745143.

Genome annotation databases

EnsembliENST00000313778; ENSP00000323265; ENSG00000178149. [Q5D0E6-4]
ENST00000341949; ENSP00000344989; ENSG00000178149. [Q5D0E6-1]
ENST00000441576; ENSP00000410623; ENSG00000178149. [Q5D0E6-2]
GeneIDi55152.
KEGGihsa:55152.
UCSCiuc003cvk.4. human. [Q5D0E6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001358 mRNA. Translation: BAA91647.1.
AK093204 mRNA. Translation: BAC04095.1.
AK093294 mRNA. Translation: BAC04123.1.
AC137630 Genomic DNA. No translation available.
BC032440 mRNA. Translation: AAH32440.2.
BC047683 mRNA. Translation: AAH47683.1.
BC054493 mRNA. Translation: AAH54493.1.
CCDSiCCDS2783.1. [Q5D0E6-4]
CCDS33754.1. [Q5D0E6-1]
CCDS63632.1. [Q5D0E6-2]
RefSeqiNP_001009996.1. NM_001009996.2. [Q5D0E6-1]
NP_001263334.1. NM_001276405.1. [Q5D0E6-2]
NP_060584.3. NM_018114.5. [Q5D0E6-4]
UniGeneiHs.654815.
Hs.708076.
Hs.745143.

3D structure databases

ProteinModelPortaliQ5D0E6.
SMRiQ5D0E6. Positions 115-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120455. 6 interactions.
IntActiQ5D0E6. 6 interactions.
MINTiMINT-6775473.
STRINGi9606.ENSP00000344989.

PTM databases

iPTMnetiQ5D0E6.
PhosphoSiteiQ5D0E6.

Polymorphism and mutation databases

DMDMi296434472.

Proteomic databases

MaxQBiQ5D0E6.
PaxDbiQ5D0E6.
PRIDEiQ5D0E6.

Protocols and materials databases

DNASUi55152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313778; ENSP00000323265; ENSG00000178149. [Q5D0E6-4]
ENST00000341949; ENSP00000344989; ENSG00000178149. [Q5D0E6-1]
ENST00000441576; ENSP00000410623; ENSG00000178149. [Q5D0E6-2]
GeneIDi55152.
KEGGihsa:55152.
UCSCiuc003cvk.4. human. [Q5D0E6-1]

Organism-specific databases

CTDi55152.
GeneCardsiDALRD3.
HGNCiHGNC:25536. DALRD3.
HPAiHPA036862.
neXtProtiNX_Q5D0E6.
PharmGKBiPA134921814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
GeneTreeiENSGT00390000014621.
HOGENOMiHOG000043068.
HOVERGENiHBG106219.
InParanoidiQ5D0E6.
OMAiAQVCKAS.
OrthoDBiEOG75MVVR.
PhylomeDBiQ5D0E6.
TreeFamiTF325601.

Miscellaneous databases

GenomeRNAii55152.
PROiQ5D0E6.

Gene expression databases

BgeeiQ5D0E6.
CleanExiHS_DALRD3.
ExpressionAtlasiQ5D0E6. baseline and differential.
GenevisibleiQ5D0E6. HS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
InterProiIPR008909. DALR_anticod-bd.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF05746. DALR_1. 1 hit.
[Graphical view]
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT ARG-299.
    Tissue: Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-299.
    Tissue: Blood and Brain.

Entry informationi

Entry nameiDALD3_HUMAN
AccessioniPrimary (citable) accession number: Q5D0E6
Secondary accession number(s): Q7Z5S7
, Q86WY1, Q8N105, Q8NA89, Q9NVU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.