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Protein

DALR anticodon-binding domain-containing protein 3

Gene

DALRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DALR anticodon-binding domain-containing protein 3
Gene namesi
Name:DALRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178149.16
HGNCiHGNC:25536 DALRD3
neXtProtiNX_Q5D0E6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178149
PharmGKBiPA134921814

Polymorphism and mutation databases

DMDMi296434472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158481 – 543DALR anticodon-binding domain-containing protein 3Add BLAST543

Proteomic databases

EPDiQ5D0E6
MaxQBiQ5D0E6
PaxDbiQ5D0E6
PeptideAtlasiQ5D0E6
PRIDEiQ5D0E6
ProteomicsDBi62736
62737 [Q5D0E6-2]
62738 [Q5D0E6-3]
62739 [Q5D0E6-4]

PTM databases

iPTMnetiQ5D0E6
PhosphoSitePlusiQ5D0E6

Expressioni

Gene expression databases

BgeeiENSG00000178149
CleanExiHS_DALRD3
ExpressionAtlasiQ5D0E6 baseline and differential
GenevisibleiQ5D0E6 HS

Organism-specific databases

HPAiHPA036862

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP619783EBI-2871865,EBI-304185

Protein-protein interaction databases

BioGridi120455, 10 interactors
IntActiQ5D0E6, 12 interactors
MINTiQ5D0E6
STRINGi9606.ENSP00000344989

Structurei

3D structure databases

ProteinModelPortaliQ5D0E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1195 Eukaryota
COG0018 LUCA
GeneTreeiENSGT00390000014621
HOGENOMiHOG000043068
HOVERGENiHBG106219
InParanoidiQ5D0E6
OMAiAQVCKAS
OrthoDBiEOG091G04DZ
PhylomeDBiQ5D0E6
TreeFamiTF325601

Family and domain databases

InterProiView protein in InterPro
IPR008909 DALR_anticod-bd
IPR037380 DALRD3
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR16043 PTHR16043, 1 hit
PfamiView protein in Pfam
PF05746 DALR_1, 1 hit
SMARTiView protein in SMART
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5D0E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRRLGVGE TLGALNAALG PGGPVWIKET RTRHLRSRDF LAPHRALQAR
60 70 80 90 100
FDDGQVPEHL LHALACLQGP GVAPVLRCAP TPAGLSLQLQ RSAVFERVLS
110 120 130 140 150
AVAAYATPAS PASLGQRVLL HCPALRSSPC ALRLSQLRTV LVADHLARAL
160 170 180 190 200
RAHGVCVRLV PAVRDPHMLT FLQQLRVDWP AASERASSHT LRSHALEELT
210 220 230 240 250
SANDGRTLSP GILGRLCLKE LVEEQGRTAG YDPNLDNCLV TEDLLSVLAE
260 270 280 290 300
LQEALWHWPE DSHPGLAGAS DTGTGGCLVV HVVSCEEEFQ QQKLDLLWQK
310 320 330 340 350
LVDKAPLRQK HLICGPVKVA GAPGTLMTAP EYYEFRHTQV CKASALKHGG
360 370 380 390 400
DLAQDPAWTE IFGVLSVATI KFEMLSTAPQ SQLFLALADS SISTKGTKSG
410 420 430 440 450
TFVMYNCARL ATLFESYKCS MEQGLYPTFP PVSSLDFSLL HDEGEWLLLF
460 470 480 490 500
NSILPFPDLL SRTAVLDCTA PGLHIAVRTE MICKFLVQLS MDFSSYYNRV
510 520 530 540
HILGEPRPHL FGQMFVRLQL LRAVREVLHT GLAMLGLPPL SHI
Length:543
Mass (Da):59,363
Last modified:May 18, 2010 - v2
Checksum:i78AFBA859D0E074B
GO
Isoform 2 (identifier: Q5D0E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-543: GEWLLLFNSI...MLGLPPLSHI → YPPLSGSAEP...RPPAASESCA

Show »
Length:516
Mass (Da):55,453
Checksum:iBB3C375E2DB6196C
GO
Isoform 3 (identifier: Q5D0E6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-138: RLSQLR → TGCACA
     139-543: Missing.

Show »
Length:138
Mass (Da):14,419
Checksum:iB6E76E24E397A7E9
GO
Isoform 4 (identifier: Q5D0E6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:376
Mass (Da):41,590
Checksum:iF0812124BD2BC042
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27I → T in BAA91647 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038349299Q → R2 PublicationsCorresponds to variant dbSNP:rs3087866Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0307411 – 167Missing in isoform 4. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_030743133 – 138RLSQLR → TGCACA in isoform 3. 1 Publication6
Alternative sequenceiVSP_030744139 – 543Missing in isoform 3. 1 PublicationAdd BLAST405
Alternative sequenceiVSP_030746444 – 543GEWLL…PLSHI → YPPLSGSAEPDSSAGLHSPG APHCCTHRDDMQVPGTAQHG FQLLLQPGTHPGGASTTPLW SDVRPPAASESCA in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001358 mRNA Translation: BAA91647.1
AK093204 mRNA Translation: BAC04095.1
AK093294 mRNA Translation: BAC04123.1
AC137630 Genomic DNA No translation available.
BC032440 mRNA Translation: AAH32440.2
BC047683 mRNA Translation: AAH47683.1
BC054493 mRNA Translation: AAH54493.1
CCDSiCCDS2783.1 [Q5D0E6-4]
CCDS33754.1 [Q5D0E6-1]
CCDS63632.1 [Q5D0E6-2]
RefSeqiNP_001009996.1, NM_001009996.2 [Q5D0E6-1]
NP_001263334.1, NM_001276405.1 [Q5D0E6-2]
NP_060584.3, NM_018114.5 [Q5D0E6-4]
UniGeneiHs.654815
Hs.708076
Hs.745143

Genome annotation databases

EnsembliENST00000313778; ENSP00000323265; ENSG00000178149 [Q5D0E6-4]
ENST00000341949; ENSP00000344989; ENSG00000178149 [Q5D0E6-1]
ENST00000441576; ENSP00000410623; ENSG00000178149 [Q5D0E6-2]
GeneIDi55152
KEGGihsa:55152
UCSCiuc003cvk.4 human [Q5D0E6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDALD3_HUMAN
AccessioniPrimary (citable) accession number: Q5D0E6
Secondary accession number(s): Q7Z5S7
, Q86WY1, Q8N105, Q8NA89, Q9NVU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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